Psoriasis Flashcards Preview

Dermatology > Psoriasis > Flashcards

Flashcards in Psoriasis Deck (19):
1

Which areas of the body can psoriasis present

Skin - on extensor surfaces
Also the nails (dystrophy) and joints

2

What is the hallmark of psoriasis lesions

Inflammation
The lesion are itchy and scaly
Well defined
Often symmetrical

3

Are psoriasis plaques reversible

Yes
With effective treatment

4

What occurs when the keranocytes are under stress

They release factors that stimulate the release of interferons and interleukins
Chemical signals activate dendritic cells which migrate to the lymph nodes and activate T cells

5

List some topical treatments for psoriasis

Emollients are key
Coal tar
Vitamin D analogue
Keratolytics
Topical steroid

6

How is treatment chosen for psoriasis

Based on the site, extent, severity, side effects and compliance

7

Describe coal tar treatment

Thick formula of coal tar
Range from mild to strong crude tar
Effective
Messy and smelly - stains clothes etc

8

Describe vitamin d analogues (pros and cons)

Clean and easy to apply
Can be an irritant
Use limited to 100g per week

9

Describe dithranol treatment

Effective
Hard to use
Irritant
Stains skin

10

What treatments are used for scalp psoriasis

Greasy ointments used to soften scale
Tar shampoos
Steroids in base or shampoo
Vitamin D analogues

11

What are some possible pathogeneses for psoriasis

Epidermal hyperplasia
Hereditary factors - associated with certain HLA types
Trauma
Complement system attacks keratin layer

12

What is the Koebner phenomenon

When psoriasis lesions appear at sites of trauma
Cause unknown

13

What is guttate psoriasis

Lots of coin shaped/sized plaque all over
Common on trunk

14

What is Acute erythrodermic psoriasis

severe and dangerous form
Affects the whole body
Very inflamed
Can lose a lot of electrolytes and fluids which leads to imbalance
Patient will feel very unwell

15

What is Auspitz sign

Removal of surface scale reveals tiny bleeding points
This is because dermal papillae extend higher into the epidermis than usually – capillaries are closer to the surface

16

What is Palmoplantar pustular psoriasis

Pustular appearance
Affects just the palms and soles of the feet
Not infected but has a lot of inflammation

17

What signs of psoriasis can be present in the nails

Onycholysis - nail plate lifts up from plate
Nail pitting
Dystrophy
Subungal hyperkeratosis

18

What are some comorbidities associated with psoriasis

psoriatic arthritis, metabolic syndrome, increased cardiovascular risk and depression

19

What non-topical treatments are available for psoriasis

Phototherapy - UVB and PUVA
Immunosuppression - methotrexate
Immune modulation