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Y2- random cant remember > psoriasis > Flashcards

psoriasis Flashcards

1
Q

drugs which can cause

A

beta blockers
lithium
antimalarials

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2
Q

basis of pathogenesis

A

hyperteratosis

parakeratosise

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3
Q

parakeratosis

A

retention of nucleu in corneocytes in the stratum corneum
due to increased proliferation reducing the time for migration and differentiation
associasted with the thinning or loss of the granular layer

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4
Q

hyperkeratosis

A

thickening of the keratin layer

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5
Q

other more unusual clinical changes in psoriasis

A

dilation and proliferaition of dermal blood vessels- become torturous
accumulation and inflammation of immune cells especially t cells in the dermis and epidermis

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6
Q

what is seen histologically in psoriasis

A

thinning of the stratum corneum
parakeratosis- absence of granular layer
prickle cell layer is thickened
lots of neutrophils

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7
Q

munro absesses

A

collection of neutrophils in the strateum corneum of the epidermis due to infiltration of neutrophils

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8
Q

most common type of psoriasis

A

chronic plaque

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9
Q

rash in chronic plaque

A

mildly itchy palpable scaly erythematous plaques

plaques often symmetrical and scale may be silvery

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10
Q

auspitz sign

A

removing scale in chronic plaque causes pinpoint bleeding

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11
Q

sign in chronic plaque

A

auspitz sign

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12
Q

where is chronic plaque seen

A

preferentially develops on the extensor aspects of knees elbows sacrum and scalp

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13
Q

psoriasis of the scalp

A

most commonly seen at the posterior aspect of the scaly

extend below the hairline and associated with itch and no interruption to hair growth

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14
Q

koebner phenomon

A

plaques similar to chronic plaque develop 2-6 weeks after trauma has occurred
trauma can be physical subburn or another skin condition

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15
Q

guttate psoriasis

A

seen in younger patients- 15 to 25

onset 7 to 10 days after an infection- strep throat

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16
Q

rash in guttate psoriasis

A

fine pear drop in shape
on trunk arms and legs
well demarcated scaly erythematous plaques

17
Q

flexural psoriasis

A

axilla
under breast
groin
common in older

18
Q

rash in flexural psoriaisis

A

erythmatos glazed well demarcated plaques with or without scale

19
Q

erythrodermic psoriasis

A

can develop de novo or in patients who have a deteriorating psoriasis
onset can be preticipated in a patient taken of potent steroids
quite serious can lead to complete failure of the skin

20
Q

rahs in erythrodermic psoriasis

A

well demarcated plaques with absent scale or very fine scaling with confluent full body erythema

21
Q

generalised pustular psoriasis

A

the skin is often painful and there is associated fever and malaise

22
Q

rash in generalised pustular psoriasis

A

sterile pustules within plaques of psoriasis and widespread erythema

23
Q

palmo plantar pustulosis

A

now considered a distinct condition that is related to psoriasis
typically women over 50
strong association with smoking

24
Q

rash in palmo plantar pustolosis

A

multiple yellow pustules that develop into brown macules that then develop scale

25
Q

nail problems in psoriasis

A

oncholysis
pitting
dystrophy
subungal hyperkeratosis

26
Q

oncholysis

A

seperastion of the nail from the nail bed

27
Q

subungal hyperkeratosis

A

extreme reproduction of skin cells

accumulate between nail and nail bed

28
Q

wht decreases life expectancy in those with psoriasis

A

increased cardiovascular risk
4 yr shorter life expectancy
also increased risk of lymphoma

29
Q

example of vitamin d analogue

A

calciptriol

calcitriol

30
Q

dithranol

A

used in short contact reginmes for stable chronic plaque disease as it burns and stain normal skin

31
Q

coal tar

A

only used on in patients due to its smell and mess

32
Q

salicylate

A

used to break down particularly hyperkeratotic skin

33
Q

side effects of phototherapy

A

subburn
conjunctivitis
excacerbation of HSV

34
Q

treatment for mild to moderate psoriasis

A

1st
topical corticosteroids
and / or
topical vitamin d analogue

more effect when used as a combo
vit d analogue counteracts side effects of the steroids

35
Q

example of the topical steroid used

A

hydrocortisone
triamcinolone
flucinodone
clobetanol

36
Q

example of topical vitamin d analogue

A

calcipotriol topical

37
Q

treatment of moderate to severe psoriasis

A

1st- phototherapy
2nd - methotrexate
bioagenet
retinol

38
Q

treatment of guttate psoriasis

A

1st- phototherapy
2nd0 methotrexate/ oral retinoid
3rd - ciclosporin

39
Q

treatment of pustular psoriasis

A

1st- oral retinoid

2nd- puva

Y2- random cant remember (6 decks)

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