Psych Drug Info Flashcards
(19 cards)
MAO inhibitor side effects
Hypertensive crisis (due to no tyramine breakdown in gut)
Potientiates other drug effects e.g. barbiturates by decreasing their metabolism
Insomnia
Postural hypotension
Peripheral oedema
Tricyclics side effects
Anticholinergic (blurred vision, dry mouth, constipation, urinary retention)
Sedation
Weight gain
Cardiovascular (postural hypotension, tachycardia, arrhythmias)
Cardiotoxic in overdose
SSRIs side effects
Headache Sweating/vivid dreams Worsened anxiety Sexual dysfunction Hyponatraemia (in elderly) Transient increase in self-harm/suicidal ideation in under 25s Discontinuation effects
SNRI side effects
Similar to SSRIs
Mirtazapine mode of action
Blocks alpha2, 5-HT2 and 5HT3 receptors
Mirtazapine side effects
Weight gain
Sedation
Can block serotonergic side effects when given with SSRIs
What is lithium usually bonded to in medication?
Carbonate (so lithium carbonate)
Potential modes of action for lithium
Block phosphatidylinositol pathway (second messenger system)
Inhibit glycogen synthase kinase 3beta
When should lithium levels be monitored?
12 hours post-dose
Lithium side effects
Dry mouth/strange taste Polydipsia and polyuria Tremor Hypothyroidism Long term reduced renal function Nephrogenic diabetes insipidus Weight gain
Lithium toxic effects
Vomiting Diarrhoea Ataxia/course tremor Drowsiness Convulsions Coma
What anti-convulsants can be used as mood stabilisers?
Valproate
Lamotrigine
Carbamazepine
What anti-psychotics are used as mood stabilisers?
Quetiapine
Aripiprazole
Olanzapine
Lurasidone
Mode of action of antipsychotics as mood stabilisers
Dopamine antagonism and serotonin antagonism
Memantine mode of action
Low-affinity voltage-dependent non-competitive antagonist of NMDA receptors
Memantine indication
Alzheimers disease
NICE says if can’t tolerate ACh inhibitors or in severe alzheimers
Methylphenidate mode of action
Increases dopamine by blocking its transporter (stimulant)
Dexamphetamine mode of action
Increases dopamine but also increases extracellular noradrenaline and serotonin
SNRI and alpha agonist action in ADHD
Increase noradrenaline
