Psychedelic misuse Flashcards
Psychedelics
-produce non-ordinary and variable forms of conscious experiences
-changes in moods, thoughts, sensations
Delusion
-fixed, false belief, unresponsive to logic
-paranoia
Hallucination
-false perception arising from internal stimuli
-creates false reality
Psychedelic classes
-classical: phenethylamine and trytamine derivatives
-dissociative: phencyclidine, ketamine, muscimol
Phenethylamine serivatives
-mescaline
-MDA
-MDMA
Derivatives of tryptamine
-DMT
-5-MeO-DiPT
-LSD
-Ibogaine
Naturally occuring classical psychedlics
-Dimethyltyrptamine (DMT)
-5-MeODMT
-psilocybin prodrug of psilocin
Mescaline
-3,4,5-trimethoxyphenethylamine
Mescaline and Phenethylamine
-amphetamine like (MDMA, bathsalts)
-inc release of 5-HT > DA, NE
-empathogens/entactogens (more hallucinogenic than stimulatory)
-llowest potency
-long lasting
-cross tolerance to LSD
most classical psychs MOA
-5-HT2A agonists
-pretreatment w antagonists blocks effects
-BUT MDMA stimulates 5HT2A release
-increase global integration, communication patterns of CNS