Psychiatry Flashcards
SSRI
Fluoxetine
Paroxetine
Sertraline
Citalopram/escitalopram
Which SSRI is contraindicated in pregnancy
Paroxetine
Which SSRI is safe for MI
Fluoxetine
SNRI
Venaflaxine
Desvenaflexine
Duloxetine
Indications for SNRI
For treating depression AS WELL AS anxiety (75% depression 25% anxiety)
Venlafaxine contraindication
- Diastolic Hypertension
- Breast feeding
Antipsychotics
Order from lowest to highest potency
Aripiprazole
Quetiapine
Olanzapine
Risperidone
Clozapine
Amisulpride??
Common adverse effect of Antipsychotics
Hyperprolactinemia (>2000 mIU/L)
galactorrhea
gynaecomastia
sexual dysfunction
infertility
amenorrhoea
Examples of Overvalued Ideas
Body dysmorphic disorder
Anorexia Nervosa
Hypochondriasis
Features of Schizophrenia
Positive symptoms
Negative symptoms
Disorganised thought
Hallucinations
Negative symptoms of Schizophrenia
flat affect
poverty of thought
lack of motivation
social withdrawal
reduced speech output
Positive symptoms of Schizophrenia
delusions
hallucinations
thought disorder
disorganized speech and behavior
Drug of choice for Bipolar disorder
Lithium
Haloperidol (Emergency, if uncooperative)
Eating disorders are commonly associated with what patient profiles (history)
– Female Adolescent
– Low self-esteem
– Personal or family history of depression
– Family history of obesity
– High personal expectations
– Family history of eating disorders
– Disturbed family interactions
- Social factors
- Childhood sexual abuse
- Perfectionism and obssessionality
Common clinical features of Anorexia Nervosa
- < 16 BMI
- Significant electrolyte disturbance (K < 3.0 or Na < 130)
– Amenorrhoea
– Constipation.
– Cold intolerance.
– Cachexia.
– Hypothermia.
– Bradycardia. (< 40bpm)
– Hypotension (< 90mmHg) - Raised liver enzymes and Albumin < 35g/L
Complications of Anorexia Nervosa
– low level of LH, FSH and TSH
- secondary amenorrhoea due to low levels of LH and FSH
-Depression
-Obsessive-compulsive disorder
- increased risk of developing bone fractures in later life due to osteoporosis
Causes of Serotonin Syndrome
Serotonin antagonist
SSRI
MAOi
TCA (perhaps)
Symptoms of Serotonin Syndrome
features that differ from NMS
– Muscle weakness, clonus and hyperreflexia
- Rapid Onset (<24hrs)
- Dose dependant
- Nausea and vomiting
- Increased bowel sounds
- Dilated pupils
features shared with NMS
- High grade fever (>40 degrees)
– Autonomic instability (hypertension, tachycardia, diarrhoea, muscle spasms & red skin, sweating).
– Mental state change (agitation, confusion, hypomania, seizure).
- Hypersalivation
-Use of benzodiazepines
Treatment of Serotonin Syndrome
- Cyproheptadine
- Chlorpromazine
St John’s Wort with antidepressant causes
Serotonin syndrome
Causes of Neuroleptic Malignant Syndrome (NMS)
- anti-emetics
- anti-psychotics
- Dopamine antagonists
- cessation of a dopamine agonist
Medications that cause Neuroleptic Malignant Syndrome (NMS)
- quetiapine
- olanzapine
- risperidone
- paliperidone
- domperidone
- metoclopramide
-promethazine
Symptoms of Neuroleptic Malignant Syndrome (NMS)
Features that differ from SS
-Slow onset
- Not dose dependant
- pupils are normal
- No nausea and vomiting
-severe muscle rigidity with hyporeflexia
Features share with SS
- High grade fever (>40 degrees)
– Autonomic instability (hypertension, tachycardia, diarrhoea, muscle spasms & red skin, sweating).
– Mental state change (agitation, confusion, hypomania, seizure).
- Hypersalivation
- Use of benzodiazepines
Treatment of NMS
Bromocriptine