Psychiatry Flashcards
(31 cards)
Third person auditory hallucinations
Schizophrenia
Mesocortical dopamine activity
Negative and cognitive symptoms in schizophrenia
Subcortical dopamine hyperactivity
Psychosis
Mesolithic Da blockade
Depression
Mesolimbic Da agonism
Psychosis
S/E of clozapine
Agranulocytosis
Cardiomyocitis
Lots of weight gain
When to prescribe clozapine
Need to try 2 other anti-psychotics first & must be a consultant to prescribe
Clozapine monitoring
Once a week for the first 6 months
Once every 2 weeks for the next 6 months
Every 4 weeks there after & one month after
Limbic system functions
M2OVE: Memory Motivation Olfaction Visceral afferents Emotion
Brain changes in schizophrenia
Reduced frontal lobe volume (and grey matter)
Enlarged lateral ventricles
Reduced grey matter in the temporal cortex
Pressure of thought
Varied ideas in abundance
Seen in mania sometimes seen in schizophrenia
Poverty of thought
Patient reports lack/absence of thoughts
Flight of ideas
Quickly moving from one topic to another, with a link
Knight’s move thinking
No link between phase A and B, seen in bipolar during manic phase
Treatment of EPSE
Procyclidine
Amygdala
Involved in normal response to threat
Management of OCD
- SSRI
- SSRI
- TCA or SSRI
- SSRI or TCA
TCA used in OCD
Chlomipramine
Borderline LD
70-80
Mild LD
50-69
Moderate LD
35-49
Severe LD
20-34
Profound LD
<20
Beck’s triad
Negative feelings about self, world and future
