Psychotropics

Question 1

where should MOAIs be managed?

Answer 1

not at the primary care level

psychiatrist

Question 2

which SSRIs are structurally similar?

Answer 2

lexapro and celexa

Question 3

what are other indications of SSRI?

Answer 3

OCD, panic d/o, GAD, PMDD, SAD, eating disorders

Question 4

which SSRI has the longest half life?

Answer 4

prozac 4-6 days

Question 5

what is the peak action of SSRIs?

Answer 5

3-8 hrs

Question 6

where are SSRIs metabolized?

Answer 6

CYP450 enzyme in the liver

Question 7

which SSRI has most liver metabolic problems?

Answer 7

luvox

Question 8

what is the MOA of SSRI?

Answer 8

inhibit re-uptake of 5HT making more serotonin available

little effect on dopamin and norepi

Question 9

which SSRI has significant anticholinergic activity at higher doses?

Answer 9

paxil

Question 10

how does SSRI withdrawal present?

Answer 10

flu like

N. fatigue, myalgia, vertigo

Question 11

what are SE of SSRI?

Answer 11

h/a, dizziness, N, D, insomnia, sexual dysfunction (everything goes away with long term use except for sexual dysfunction)

Question 12

what are drug interactions that can cause serotonin excess?

Answer 12

SSRI + MAOI OR Triptan OR lithium

Question 13

what is hallmark of serotonin syndrome?

Answer 13

**mental status change
**autonomic hyperactivity
**neuomuscular abn
D, restlessness, agitation, hyperreflexives, myoclonus, seizures, hyperthermia, AMS, death