PUBLIC HEALTH Flashcards

(98 cards)

1
Q

What is sensitivity?

A

Sensitivity: The ability of a test to correctly identify those with the condition (true positive rate).

TP / (TP + FN )

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2
Q

What is specificity?

A

Specificity: The ability of a test to correctly identify those without the condition (true negative rate).

Proportion of patients without the condition who have a negative test result

TN / (TN + FP)

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3
Q

What is the positive predictive value?

A

The chance that the patient has the condition if the diagnostic test is positive

TP / (TP + FP)

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4
Q

What is Negative predictive value?

A

The chance that the patient does not have the condition if the diagnostic test is negative

TN / (TN + FN)

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5
Q

What is the likelihood ratio for a positive test result?

A

Likelihood Ratio for a Positive Test (LR+): How much more likely a positive test result is in someone with the condition compared to someone without it.

sensitivity / (1 - specificity)

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6
Q

What is the likelihood ratio for a negative test result?

A

Likelihood Ratio for a Negative Test (LR-): How much less likely a negative test result is in someone with the condition compared to someone without it.

(1 - sensitivity) / specificity

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7
Q

What is a problem with case control studies?

A

Recall bias

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8
Q

What is a Cohort study?

A

Observational and prospective. Two (or more) are selected according to their exposure to a particular agent (e.g. medicine, toxin) and followed up to see how many develop a disease or other outcome.

The usual outcome measure is the relative risk.

Examples include Framingham Heart Study

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9
Q

What is a case-control study?

A

Look at group of people w a condtion, and compare them to a control group.

Researchers look back to see if there were any differences in exposures or risk factors between the groups. It helps find possible causes of the condition.

The usual outcome measure is the odds ratio.

Inexpensive, produce quick results
Useful for studying rare conditions
Prone to confounding

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10
Q

What is a cross-sectional study?

A

Provide a ‘snapshot’, sometimes called prevalence studies

Provide weak evidence of cause and effect

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11
Q

What is a type 1 error?

A

Two types of errors may occur when testing the null hypothesis
type I: the null hypothesis is rejected when it is true

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12
Q

What is a type 2 error?

A

type II: the null hypothesis is accepted when it is false - i.e. Failing to spot a difference when one really exists, a false negative.

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13
Q

How do you work out relative risk?

A

Work out the odds in each group.

Then divide the odds of each group together and that gives you the outcome

EER/CER

Relative risk reduction (RRR) or relative risk increase (RRI) is calculated by dividing the absolute risk change by the control event rate

Using the above data, RRI = (EER - CER) / CER = (0.6 - 0.25) / 0.25 = 1.4 = 140%

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14
Q

What is absolute risk reduction?

A

Absolute risk reduction (ARR) is calculated as the difference in event rates between two groups. In this context, it represents the additional benefit of one treatment over another in reducing pain.

Subtracting the risk of pain in the usual treatment group (1,340 / 1,530) by the risk of pain in the current best treatment group (1,578 / 1,820). 87.6% - 86.7% = 0.9%

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15
Q

How do you work out odds ratio?

A

odds of contracting the condition in the exposed / odds of contracting the condition in the unexposed.
eg

40 out of 60 smokers have lung cancer
10 out of 90 non smokers have lung cancer

Odds of lung cancer in smokers 40/60
odds of lung cancer in non smokers 10/90

40/60 = 0.66
10/90 =0.11

0.66/0.11= 6

This means smokers are 6 times more likely to have the disease compared to non-smokers.

Interpretation:
OR = 1: No association between exposure and outcome.
OR > 1: Positive association (exposure increases odds of the event).
OR < 1: Negative association (exposure decreases odds of the event).

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16
Q

Different types of plot chart?

A

Funnel plot: Funnel plots are primarily used to demonstrate publication bias in meta-analyses. As publication bias is being investigated here, and the researcher is conducting a meta-analysis, a funnel plot is the best answer

Box-and-whisker plot: This is a graphical representation of the sample minimum, lower quartile, median, upper quartile and sample maximum. This helps show the distribution of quantitative data. However, it does not demonstrate publication bias.

Forest plot Forest plots are usually found in meta-analyses and provide a graphical representation of the strength of evidence of the constituent trials

Histogram A graphical display of continuous data where the values have been categorised into a number of categories

Scatter plot Graphical representation using Cartesian coordinates to display values for two variables for a set of data

Kaplan-Meier survival plot A plot of the Kaplan-Meier estimate of the survival function showing decreasing survival with time

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17
Q

What is the standard error of the mean?

A

Standard error of the mean = standard deviation / square root (number of patients)

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18
Q

What are the advantages and disadvantages of a case-control study?

A

Advantages:
- Good for rare outcomes
- Quicker than cohort or intervention
- Can investigate multiple exposures

Disadvantages:
- Difficulties finding controls of match with cases
- Prone to selection and information bias

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19
Q

What are some advantages and disadvantages of cohort studies?

A

Advantages:
- Can follow-up group with a rare exposure
- Good for common and multiple outcomes
- Less risk of selection and recall bias

Disadvantages:
- Take a long time
- Loss to follow up
- Need a large sample size

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20
Q

What are some advantages and disadvantages of a cross-sectional study?

A

Advantages:
- Cheap and quick
- Provide data on prevalence at a single point in time
- Large sample size
- Good for public health planning

Disadvantages:
- Risk of reverse causality (don’t know whether outcome or exposure came first)
- Cannot measure incidence
- Risk of recall bias and non-response

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21
Q

What are the advantages and disadvantages of RCT?

A

Advantages:
- Low risk of bias and confounding
- Can infer causality

Disadvantages:
- Time consuming
- Expensive
- Specific inclusion/exclusion criteria may mean the study population is different from typical patients

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22
Q

What are the different factors that can explain associations?

A
  • Chance
  • Bias
  • Confounding
  • Reverse causality
  • A true association
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23
Q

What is selection bias and what can cause it?

A

Systematic error in the selection of study participants of the allocation to different study groups

  1. Non- response
  2. Loss to follow up
  3. Are those in the intervention group different to those in the control group
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24
Q

What are the different types of information bias?

A

Measurement (e.g. different equipment used to measure the outcome in the different groups)

*Observer (e.g. the researcher knows which participants are cases and which are controls and subconsciously reports/measures the exposure or outcome differently depending on which group they are in)

  • Recall (e.g. events that happened in the past are not remembered and reported accurately)
  • Reporting (e.g. respondents report inaccurate information because they are embarassed)
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25
What is a cross-sectional study?
Provide a 'snapshot', sometimes called prevalence studies Provide weak evidence of cause and effect
26
Define what numbers needed to treat is
The number of patients who need to receive a treamtment in **Order for one person to benefit** worked out as 1/absolute risk reduction say a drug reduced risk of MI from 10% to 5% absolute risk reduction would be 0.05 (5%) 1/0.05 = 20 so 20 people would needed to take drug to prevent one person having a heart attack
27
In the theory of planned behavior what 3 factors influence intentions?
**Attitude towards the behavior**: this refers to an individual's positive or negative evaluation of performing the behavior **Subjective norm**: this reflects the perceived social pressure to engage or not engage in the behavior. It involves the influence of important others (e.g., family, peers, society) and their expectations or approval of the behavior (e.g., "Do people who matter to me think I should do this?"). **Perceived behavioral control (PBC)**: This refers to the individual's perception of their ability to perform the behavior, influenced by both internal factors (e.g., self-confidence, skills) and external factors (e.g., availability of resources, opportunities). It is similar to the concept of self-efficacy. The more control a person believes they have over performing a behavior, the more likely they are to intend to do it.
28
The TPB model
Attitude: Beliefs about the behavior → Evaluation of outcomes (positive/negative) Subjective Norm: Normative beliefs (perceptions of others' expectations) → Motivation to comply Perceived Behavioral Control: Control beliefs (resources, opportunities) → Confidence in ability to perform the behavior Intention: The likelihood of engaging in the behavior Behavior: The actual action or decision **ASP**
29
What are the strengths and weaknesses of the TPB?
Strengths: It provides a comprehensive framework that includes both individual (attitude, perceived control) and social (subjective norm) factors. It has been empirically supported in many domains, especially health psychology and consumer behavior. Limitations: TPB assumes that people are rational decision-makers, which doesn't always align with real-world, emotional, or impulsive behaviors. It can be hard to measure some of the constructs, especially perceived behavioral control, which is often subjective. The model primarily focuses on individual-level factors and might not fully account for systemic or structural barriers.
30
What are the 3 ways to perform a health needs assessment? What is a health needs assessment?
A Health Needs Assessment (HNA) identifies the health needs of a population to prioritize and allocate resources effectively. It evaluates gaps in services and helps plan interventions to improve public health. 1. epidemiological 2. Corporate 3. Comparative
31
What is the epidemiological approach to a health needs assessment?
Epidemiological Approach: Focuses on data and statistics. Analyzes the prevalence, incidence, and distribution of diseases. Uses evidence from studies to identify health problems.
32
What are some pros and cons to an epidemiolocal approach to a health needs assessment?
Advantages: - Uses existing data - Provides data on disease - Incidence - Can evaluate services by trends over time Disadvantages: - Quality of data variable - Data collected may not be the data required - Does not consider the felt needs or opinions/experiences of the people affected
33
What is the corporate approach to a health needs assessment?
- Ask the population what their needs are - Use focus groups meetings etc - Engages stakeholders (e.g., community groups, healthcare providers).
34
What are the advantages and disadvantages to the corporate approach?
Advantages: - Based on the felt and expressed needs of the population in question - Recognises the knowledge of those in the population - Takes into account a wide range of views Disadvantages: - Difficult to distinguish need from demand - Groups may have vested interest - May be influenced by political agendas
35
What is the comparative approach to a health needs assessment?
Compares services or health outcomes across populations (e.g., regions or countries). Highlights inequalities and areas needing improvement. Identifies "best practices" for replication.
36
What are the Adv vs Dis for comparative approach?
Adv: - Quick and cheap - Gives a measure of relative performance Dis: - May be difficult to find comparable population - Data may not be available/high quality - May not yield what the most appropriate level (e.g. of provision or utilisation) should be
37
What are Bradshaw's 4 types of health need?
Bradshaw's 4 Types of Health Needs provide a framework to understand different perspectives on health needs: Normative Need: Felt Need: Expressed Need: Comparative Need: Summary: Bradshaw's framework distinguishes between needs defined by experts, individuals, and comparisons to ensure a comprehensive approach to addressing health needs.
38
Bradshaws types of health need - define and give example of normative and felt need
Normative Need: Defined by professionals or experts based on standards or guidelines. Example: A doctor recommends vaccinations to reduce disease risk. Felt Need: What individuals feel they need, based on personal experiences. Example: A person reports feeling anxious and seeks mental health support.
39
Bradshaws types of health need - define and give example of Expressed need and comparative need
Expressed Need: A felt need that has been acted upon or expressed as a demand. Example: Long waiting lists for physiotherapy reflect expressed demand for the service. Comparative Need: Identified by comparing one group to another with similar characteristics. Example: One area has fewer healthcare facilities than a neighboring area with the same population size.
40
What are the key components of Beckers health belief model?
Perceived Susceptibility Perceived Severity Perceived Benefits Perceived Barriers Cue to action Self-Efficacy Social and Environmental Factors
41
What is Perceived Susceptibility?
An individual’s belief about the likelihood of getting a disease or condition. For example, someone who believes they are at high risk of developing diabetes is more likely to take preventive measures (such as dieting or exercising).
42
What is perceived severity?
An individual’s belief about the seriousness of a health issue and its consequences. If someone believes that a condition like lung cancer will have severe consequences, they may be more motivated to stop smoking.
43
What is perceived benefits?
The belief that taking a specific action will reduce the threat of a health problem. For instance, if an individual believes that wearing a seatbelt significantly reduces the risk of injury in a car accident, they are more likely to wear one.
44
What is perceived barriers?
The perceived obstacles or costs associated with taking the recommended health action. Even if an individual believes that exercise will improve their health, they may avoid it due to perceived barriers like lack of time or energy.
45
What is Cue to action?
A trigger that motivates a person to take action. This could be an internal cue, such as feeling unwell, or an external cue, such as a health campaign or a doctor's recommendation.
46
What is self-efficacy?
Added later by Becker and others, this refers to the belief in one’s ability to successfully carry out the recommended health behavior. The higher one's self-efficacy, the more likely they are to take action. This concept emphasizes confidence in personal ability to make health changes.
47
What are the 3 applications of becker's model?
Health promotion campaigns: It can be used to design interventions that target specific beliefs (e.g., promoting awareness about the risks of smoking). Chronic illness management: For people managing long-term conditions, understanding perceived barriers and benefits (e.g., taking medication regularly) can help improve adherence. Public health initiatives: The model is used to tailor messages about vaccines, screenings, or health behaviors by addressing individuals’ concerns and motivations.
48
What are the 9 criteria in Wilson and Jugner screening criteria?
- Should be an important health problem (IH) - Should be an accepted treatment (AT) - Facilities and treatment should be available (FT) - Should be a recognizable latent or early symptomatic stage. (RE) - Suitable test or examination (ST) - Natural history of the condition, should be understood (HU) - Should be an agreed policy on whom to treat. (AP) - Costs of the screening program (including diagnosis and treatment) should be balanced against the benefits. (CB) - Case-finding should be a continuing process (CP) I Ate Fitty strawberries, hungry asain-pakistani cabbies copulate
49
What are the factors for causality in the Bradford-hill criteria?
- Strength - Consistency: same result from various studies - Dose-response - Temporality: Exposure occurs prior to outcome - Plausibility: Reasonable biological mechanism - Reversibility: Intervention to reduce/remove exposure eliminates/reduces outcome - Analogy: Similarity with other established cause-effect relationships - Specificity: Relationship specific to outcome of interest
50
What is length time bias?
- studies when the detection of a disease or condition is more likely to occur in individuals with a slower progression of the disease, leading to an overestimation of survival rates or the effectiveness of a treatment
51
What is lead time bias?
detecting the presence of disease earlier, screening can appear to increase length of survival even if it has no impact on the course of the disease.
52
What are the stages of the transtheoretical model?
Pre-contemplation Contemplation Preparation Action Maintenance relapse can occur at any stage
53
What are the 4 main beliefs of the health belief model?
Belief they are susceptible to the condition, Belief in serious consequences, Belief that taking action reduces susceptibility, Belief that the benefits of action outweigh the costs
54
What are Bradshaw's 4 types of health need?
**Normative Needs**: These are health needs based on objective, expert-defined criteria, typically related to health standards or guidelines. For example, a health need that is defined by medical experts, such as the need for a specific vaccination or health screening based on age or risk factors. **Felt Needs**: These are health needs that individuals or communities perceive and feel. Felt needs are subjective and based on personal experiences or self-reported symptoms. For example, a person may feel they need support for stress or mental health, even if there is no clear medical diagnosis. **Expressed Needs**: These are health needs that are articulated by individuals or communities through their behaviour, such as seeking medical treatment, making appointments, or using healthcare services. Expressed needs are needs that people actively try to address by accessing health services. **Comparative Needs**: These are health needs identified by comparing different populations or groups. Comparative needs look at disparities between groups, such as differences in health outcomes, health service access, or health behaviours. For example, comparing the incidence of heart disease in one community versus another may reveal differences in health needs.
55
Centor score
- Fever above 38 - Tonsilar exudates - under 15 - No cough - Tender lymph nodes
56
Paeds red flags
Lost developmental milestones Not able to hold an object at 5 months Not sitting unsupported at 12 months Not standing independently at 18 months Not walking independently at 2 years Not running at 2.5 years No words at 18 months No interest in others at 18 months
57
Indications to early referral fertility services
Age > 35 Amenorrhoea or oligomenorrhea Previous abdo/pelvic surgery Previous STI/PID Previous urogenital surgery Previous STI Varicocele Two abnormal semen results.
58
What is considered a staggered overdose for paracetamol?
Staggered overdose is defined as the first and last paracetamol ingested being more than 1 hour apart.
59
causes of health inequalities identified in the Black Report:
1. Socio-Economic Status (SES) 2. Education 3. Housing Conditions 4. Access to Healthcare 5. Nutrition and Diet 6. Lifestyle and Behavioural Factors 7. Work Environment 8. Environmental Factors 9. Intergenerational Disadvantage Some evil scientists experimented, hurting children and hiding nasty diseases, letting big weapnes end everyones future in diaster
60
What were the key findings of the black report
Social Determinants of Health: It emphasized that health inequalities were largely shaped by social and economic factors, such as poverty, poor housing, and limited access to education and healthcare, rather than biological or genetic factors alone. Class-Based Health Inequalities: People in lower social classes had worse health outcomes across nearly all measures, and this disparity was particularly pronounced in mortality rates. Health Inequality Persistence: The report concluded that inequalities in health were persistent over time and not simply the result of lifestyle choices or differences in healthcare access.
61
Venous sinus thrombosis
Headache, which is present in 90% of cases Weakness or impaired control of one or both sides of the body Difficulty speaking or understanding language Blurred or double vision Seizures Nausea and vomiting Fainting or loss of consciousness Coma Eye pain or swelling of one or both eyes Rash that looks like small bruises or bleeding under the skin
62
PH definitions: Equity
Giving people what they need to achieve equal outcomes
63
Odds ratio?
Odds ratios are the usual reported measure in case-control studies. It approximates to relative risk if the outcome of interest is rare. Odds in treatment group/odds in placebo
64
PH definitions: Equality
Giving everyone the same rights, opportunities and resources
65
Horizontal equity
Equal treatment for people with the equal health care needs
66
Vertical equity
Unequal treatment for unequal health care needs
67
Inverse care law
Availability of health care tends to vary inversely with its need
68
What are the determinants of health?
P- Place of residence R- Race O- occupation G- gender R- Religion E- Education S- Socio economic S- Social capital
69
What are the 3 domains of public health practice?
- Health improvement - Health protection - Improving services
70
What are the two ways for assessing quality of healthcare?
- Maxwell's dimensions of quality of healthcare - Donabedian’s
71
Outline what is seen in the Donabedian framework, for evaluating health services
Structure - What is there (buildings, staff, equipment available) Process - What's actually done (number of pts seen, operations performed) , **output** - either separate or included In process Outcome - Different ways to classify outcomes, such as 1. 5Ds - Death, disease, disability, discomfort, dissatisfaction 2. Mortality 3. Morbidy (complication rate) 4. Quality of life/ Patient-reported outcomes 5. Patient satisfaction **SPO**
72
What are Maxwell's dimensions of quality of healthcare?
3 A's and 3 E's - Acceptability - Accessibility - Appropriateness - Effectiveness - Efficiency - Equity
73
What are the approaches to resource allocation?
Egalitarian Maximising Libertarian
74
What is the egalitarian approach to resource allocation and what are the advantages and disadvantages?
Provide ALL care that is necessary and required for everyone Good: equal Bad: expensive
75
What is the maximising approach to resource allocation and what are the advantages and disadvantages?
Act is evaluated solely in terms of its consequences Good: Resources are allocated to those most likely to benefit from it Bad: Those who don't make the cut receive nothing
76
What is the libertarian approach to resource allocation?
Each is responsible for their own health Good: promotes positive engagement Bad: most diseases are not self-inflicted
77
What are the different types of prevention?
Primary Prevention: Preventing the disease from occurring in the first place e.g. vaccine Secondary Prevention: Early identification of the disease to alter disease course e.g. screening Tertiary Prevention: Limit consequences of established disease e.g. Limit consequences of established disease e.g. preventing worsening renal function in CKD
78
Key terms in prevenetion: Define Population approach High Risk approach Prevention paradox
Population approach: Prevention approach delivered to everyone to shift the risk factor distribution curve e.g. dietary salt reductions through legislation High risk approach: Identify individuals above a chosen cut off and treat them e.g. screening people for high blood pressure and treat them Prevention paradox: “A preventative measure which brings much benefit to the population often offers little impact to each participating individual.” e.g. mass immunisation
79
What are the 3 screening programs in pregnancy?
- HIV, syphilis, Hepatitis B - Sickle cell and thalassaemia screening 10-13 weeks if parents are carriers, via CVS, or by aminocentesis in 15-20 weeks - Foetal anomaly screening, including Downs Syndrome
80
What are the 3 screening in new-born babies?
- NIPE - New-born Hearing Screening Programme (permanent childhood hearing impairment). Otoacoustic hearing test, down around 4-5 weeks, - New-born blood spot screening test
81
What are the 5 young people and adult screening programs?
AAA screening programme Bowel Cancer Screening - 60-74 years, every 2 years, FIT test Breast Cancer Screening Cervical Screening Diabetic Eye Screening
82
What are the 4 domains in the Wilson and Jugner criteria?
**Knowledge of Disease** Important Disease understood Recognisable stage **Treatment** Accepted treatment Enough facilities Agreed policies on who to treat **The Screening Test** Suitable test Accepted by public **Organisation and Cost** Cost of case findings balance out to possible expenditure Ongoing process I(Important disease)n E(effective treatment available)am S(simple and safe)eason NAP (Natural history, Acceptable, Policy agreed) In Exam Season NAP
83
How to work out odds?
To work out odds, you divide the probability of an event occurring by the probability of the event not occurring
84
Risk and risk ratios
Absolute Risk (AR) = the number of events (good or bad) in a treated (exposed) or control (non-exposed) group, divided by the total number of people in that group - Absolute Risk Reduction (ARR) = the AR of events in the control group (ARc) - the AR of events in the treatment group (ARt) - Relative Risk (RR) = AR(Treatment) / AR(Control) (Doesn’t take into account baseline risk) Relative risk reduction = (EER - CER) / CER
85
Define what NNH is, and how to work it out
The Number Needed to Harm (NNH) is a statistical measure used in clinical research to quantify **how many patients need to be exposed to a specific intervention or treatment** over a certain period to cause harm in one additional person **compared to a control group**. = 1 / (ARt – ARc) ARt = Attributable risk in treatment group ARc = Attributable risk in control gourp Example: If a new drug causes an adverse event in 10% of the treatment group (ARt = 0.10) and in 5% of the control group (ARc = 0.05): NNH = 1/(0.1-0.05) =1/0.05 = 20 people
86
What are the 4 types of information bias?
Measurement bias Different equipment measuring differently Observer bias Observers expectations influence reporting Recall bias Past events not recalled correctly Reporting bias People don’t tell the truth because of shame/ judgement
87
What are two other types of bias?
Selection bias Bias in recruiting for a study, and some may be lost to follow up Publication bias Trials with negative results less likely to be published
88
What are the 3 types of health behaviour?
Health Behaviour - aimed to prevent disease E.g. regular exercise Illness behaviour - aimed to seek remedy E.g. going to the doctor Sick Role Behaviour - aimed at getting well E.g. taking medication
89
What are some levels of dependancy?
Cravings – very strong desire to drink Drinking despite negative consequences: On their physical health, On their mental health, On their social / work life Tolerance – this is said to occur when the individual has to drink larger amount of alcohol to obtain a similar effect. Loss of control Narrowing of repertoire (start to drink only one type of drink in one place) wIthdrawal symptoms Primacy (put drinking before other activities) – neglecting other activities
90
What are the 4 dimensions of food insecurity?
Availability (affordability) of food Access – economic and physical Utilisation – opportunity to prepare food Stability of the three dimensions over time
91
What is the Bolam rule in negligence?
Would a reasonable doctor do the same
92
What is the Bolitho rule in negligence?
Would that be reasonable?
93
What are the different types of Error?
Sloth error: being lazy, not bothering to check results/information for accuracy. Lack of skill: lack of appropriate skills or teaching in practice Communication breakdown: unclear instructions or plans and not listening to others System failure: machine/equipment stopped working Human factors: bravado, timidity Judgement failure Neglect Poor performance Misconduct
94
Which measure is most appropriate for analysing the varying risk of mortality over time
hazard ratio is typically used when analysing survival over time
95
What is point prevalence?
Point prevalence = number of cases in a defined population / number of people in a defined population at the same time
96
What is the Hawthorne effect?
Hawthorne effect - describes a group changing it's behaviour due to the knowledge that it is being studied
97
Give TWO models used to describe situations leading to errors
Swiss cheese model Three-bucket model
98
Red flags paeds?
- Grunting - Resp rate over 60 - Seizures - bulging fontanelle - temp over 38 under 3 months - Cyanosis - Mottled skin - Difficult to rouse - Moderate or severe recessions - Non-blanching rash