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Flashcards in Pulmonary Circulation 2 Deck (35):
1

What is pulmonary hypertension?

Mean pulmonary artery pressure greater than 25 mmHg

 

(normal is 15-18 mmHg)

2

What can cause an increase in pulmonary artery pressure?

1. Increased pulmonary vascular resistance

2. Increased left atrial pressure

3. Increased cardiac output (rarely by itself)

 

PAP - LAP = CO x PVR

PAP = (CO x PVR) + LAP

3

What are the 2 kinds of pulmonary hypertension?

1. Pre-capillary pulmonary hypertension (pulmonary arterial hypertension) - PCWP is less than or equal to 15 mm Hg

2. Post-capillary pulmonary hypertension (pulmonary venous hypertension) - PCWP is greater than 15 mm Hg (this includes the left atrial pressure so if you have a problem with the mitral valve, you can have post-capillary pulmonary (venous) hypertension)

 

4

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B. WHO Group 2 Pulmonary Hypertension due to left heart disease (because PCWP is greater than 15 mmHg)

5

What are 3 causes of acute pulmonary hypertension?

1. Pneumonia (hypoxic vasoconstriction)

2. Hypoxia (high altitude)

3. Thromboembolic disease

6

What are the risk factors for DVT?

Virchow's Triad:

- Trauma

- Stasis

- Hypercoaguability

7

Pulmonary Embolisms result in ____ _____ strain/failure which leads to increased _______ and decreased ______.

Right ventricle strain ("submassive") or failure ("massive"), increased myocardial O2 demand, decreased myocardial O2 delivery.

 

This cycle leads to death

8

What is Wells' DVT Score?

It's a score that is given depending on clinical features that cause risk for DVT.

 

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9

What is the Wells' PE Score?

This uses clinical features to predict probability of developing a PE.

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10

How do you diagnose PE?

History and physical (e.g. Wells' scores)

D-dimer (breakdown products of thrombin)

ECG

CXR

V/Q scan

CT angiogram

Angiogram

Echocardiography

11

What ECG findings are typically seen for PE?

Classic finding but less often seen is SI, QIII, TIII (prominant S wave in lead I, prominant Q wave and inverted T wave in lead III)

Most commonly seen is sinus tachycardia

12

What is CXR like on patients with PE?

CXR is typically normal but it is used to exclude other processes.

A couple findings that can sometimes be found are Hamptom's Hump (showing infarcted area of lung) or Westermark's sign (showing hypoperfusion of a lung--the lung is more translucent than usual)

 

 

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13

What is V/Q scan and how is it used to detect PE?

V/Q scan is a nuclear medicine scan that can visualize ventilation vs. perfusion. The patient inhales an agent while taking another through IV and the ventilation scans are compared with perfusion to see if they match. In a patient with PE, they will have mismatch defects that often look like wedges.

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14

How is CT angiography used to diagnose PE?

A contrast agent is given and when visualized on CT you can see where blockages are. In this image, you can see the gray area that is blocked

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15

How is an angiogram used to diagnose PE?

This is rarely performed these days but used to be gold standard. It is done by inserting a catheter into the pulmonary vessel and you shoot die in to look for occlusions and defects

16

How do you treat Stable ("submassive") PE? (3)

Parenteral anticoagulation (heparin unfractionated or LMWH)

Catheter directed thrombolysis (tPA)

Oral anticoagulation (warfarin)

17

How do you treat unstable ("massive") PE?

These patients are hypotensive and have RV failure.

-Heparin

-Thrombolysis (tPA) (this can be risky as it causes bleeding but it is used since this is an emergency situation)

-IVC Filter (prevents further clots from coming up the leg)

-Surgical thrombectomy

18

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B. A large infiltrate on chest x-ray

 

You would expect to find an incompressible deep vein in the leg on ultrasound, you would expect to find an elevated plasma d-dimer, and you would expect an intraluminal filling defect on CT chest with contrast. However, you would not expect anything in the lung fields.

19

What are the 5 WHO groups for pulmonary hypertension?

1. Pulmonary arterial hypertension

2. PH due to left heart disease

3. PH due to lung diseases and/or hypoxia

4. Thromboembolic pulmonary hypertension

5. PH with unclear/multifactorial mechanisms

20

Which pulmonary hypertension WHO groups are in the pulmonary arterioles vs pulmonary venous system?

Pulmonary arterial hypertension, Pulmonary hypertension due to lung diseases and/or hypoxia, and thromboembolic pulmonary hypertension (classes 1, 3, and 4) are typically in the pulmonary arterioles.

Pulmonary hypertension due to left heart disease (class 2) is found in the pulmonary venous system.

 

Class 5, miscellaneous (sarcoidosis, LAM, etc) is variable.

21

Pulmonary hypertension is defined by having a mean PAP greater than or equal to 25 mmHg. What is the definition for pulmonary arterial hypertension (PAH)?

Mean PAP greater than or equal to 25 mmHg AND

PCWP/LVEDP less than or equal to 15 mmHg AND

PVR is greater than 3 wood units

22

What is idiopathic pulmonary arterial hypertension?

This a rare and fatal form of pulmonary arterial hypertension that is paradigmatic of WHO Group 1 Disease.

It affects young women preferentially (3:1 F:M) and usually occurs in 3rd and 4th decades of life. The incidence is 1 per million per year and the median survival without treatment is 2.8 years and with treatment is 7 years.

23

Interpret this diagram

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As pulmonary arterial hypertension progresses, the cardiac output starts to fail. Once the cardiac output fails, the pulmonary arterial pressure also falls because the heart is unable to overcome the increasing pulmonary vascular resistance. Also notice that there is a rise in BNP starting around NYHA 3 that is released during heart failure.

24

What does CXR look like for pulmonary arterial hypertension as the disease progresses?

As you get decreased perfusion to the lungs, the lung fields start to look more transparent. Also, the cardiac silhouette gets larger and larger.

25

What is the physical exam like for pulmonary arterial hypertension?

Distended neck veins

Lung auscultation is normal (no rales)

Cardiac exam had a loud P2, murmur of the tricuspid regurgitation

Edema in extremeties

26

How do you treat pulmonary arterial hypertension?

Treat underlying cause (liver disease, HIV, etc)

Correct hypoxia (supplement oxygen)

Control intravascular volume status (limit fluid intake, limit sodium intake, diuresis)

Anticoagulation (?)

Pulmonary vasodilators

Lung transplantation

27

What are the key treatment target pathways in pulmonary arterial hypertension? What are some drugs in these categories?

1. Endothelin pathway (endothelin receptor antagonists: bosentan, ambrisentan, macitentan)

2. Nitric oxide pathway (phosphodiesterase-5 inhibitors: sildenafil, tadalafil; soluble guanylate cyclase stimulator: riociguat)

3. Prostacyclin pathway (prostacyclin analogs: epoprostenol, treprostinil, selexipag)

28

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D. Obtain a right heart catheterization

 

 

You need to diagnose the pulmonary arterial hypertension before you start sildenafil.

29

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B. Start a pulmonary vasodilatory like sildenafil.

 

 

You wouldn't do a heparin drip because the V/Q scan was negative so there is no blood clot. You wouldn't do a surgical lung biopsy or lung transplant evaluation (not severe enough for transplant)

30

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D. lung transplant evaluation

 

 

V/Q is still negative so no need for heparin.

IV fluids would cause a problem because these patients are volume sensitive and get overloaded easily (must watch sodium and water intake).

This patient is at the bad part of the pulmonary hypertension curve where the PVR is rising and the CO is falling.

 

31

What is chronic thromboembolic disease (WHO Group 4 disease) and how is it treated?

About 3% of patients who have an acute PE develop CTEPH where the blood clot scars into the lung. In this patient, you can give blood thinners, tPA, etc which will prevent further clots but it won't resolve the fibrous material from the scar that is causing the hypertension. Curative therapy for this is surgical pulmonary endarterectomy followed by long-term anticoagulation.

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D. Refer for pulmonary endartectomy

 

The patient is already on warfarin so there is no need to do heparin drip or tPA. The wedge pressure is not elevated so there isn't a volume problem--no need for diuretics. This patient would most likely benefit from surgical pulmonary endartectomy (typical treatment for WHO group 4 chronic thromboemboli disease)

33

How do you treat pulmonary venous hypertension?

- Decrease intravascular filling (limit fluid intake, limit sodium intake, diuresis)

- Improve LV contractility (decrease LV afterload by controlling systemic hypertension)

- Correct causes of LV failure (ischemia, valvular disease)

 

Do not use PAH specific therapy for PVH

34

True or False: You can use PAH specific therapy for PVH

FALSE! DO NOT USE PAH SPECIFIC THERAPY FOR PVH

 

Treating them with PAH specific therapy will cause pulmonary edema. If you vasodilate on the arterial side, there will be increased blood flow into the capillaries but the fluid will be stuck in the capillaries because the hypertension is still present in the venous side. This increased pressure causes pulmonary edema.

35

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B. Start diuretics

 

High wedge pressure means you should give diuretics