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Flashcards in Pulmonary Fungal Infection 2 Deck (11)
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1

what are the major human opportunistic mycoses?

1. candidiasis
2. cryptococcosis
3. aspergilliosis
4. mucormycosis
5. fusariosis

2

what is the most important predisposition for the opportunistic mycoses?

prolonged neutropenia due to
1) infections
2) aplastic anemia
3) arsenic poisoning
4) cancer
5) chemo/radiation therapy
6) medications
7) hereditary disorders
8) vitamin def
9) autoimmunity
10) hemodialysis
11) splenic sequestration

3

what are the 2 cryptococcosis?

1. Cryptococcus neoformans
2. Cryptococcus gatti

4

what are the characteristics of Cryptococcus neoformans?

1. environmental
2. found worldwide in soil contaminated with bird droppings (especially pigeon)

5

Cryptocococcosis have

oval yeast with narrow-based buds and wide polysaccharide capsule

6

Is cryptococcosis thermally dimorphic?

no, does not have a moldlike sexually reproducing form in environment called filobasidiella neoformans

7

how is cryptococcus transmitted?

by inhalation via pigeon droppings may be contagious for years

8

lung infection may be

asymptomatic or lead to pneumonia

9

what is unique about meningitis caused by cryptococcus?

1. fever and stiff neck are less common which arise from inflammation
2. associated with sensory issues with eyes or ears

10

what are focal neurologic defects called due to cryptococcus?

cryptococcomas

11

what does blunted inflammatory response do?

1. complicates diagnosis
2. means that presentation is late in dz