Flashcards in Pulmonary Fungal Infection 1 Deck (14)
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1
what are the charecteristics of systemic mycoses?
1. all environmental
2. thermal dimorphism --> so once in the lung, it becomes dimorphism
3. not person to person transmissible
2
what is the fungus that belongs to coccidioides?
coccidioides immitis
3
what are the charecteristics of coccidiodes immitis?
dimorphic --> mold in soil, spherule in tissue
4
what is the region where you can find coccidiodes immitis?
endemic in southwest US and Latin America
5
in soil, coccidioide immitis forms
hyphae with alternating arthrospores and empty cells
6
what are the four fungi that are considered as systemic mycoses?
1. histoplasmosis
2. blastomycosis
3. coccidioidomycosis
4. paracoccidioidomycosis
7
what are the characteristics of the systemic mycoses?
1. all can cause pneumonia and can disseminate
2. all are caused by dimorphic fungi (cold --> mold, heat --> yeast), the only exception being coccidioidomycosis, which is spherule (not yeast in tissue)
8
what is the name of the tissue form of coccidioidomycosis?
spherule
9
what is the regional association of coccidioidomycosis?
southwestern US, California
10
after a earthquake spores in dust are thrown up in the air and spherules in the lungs are found, what is the causative agent?
coccidioidomycosis
11
what is spherule found from coccidioidomycosis?
much larger than RBC filled with endospores
12
what are the clinical characteristics of coccidioidomycosis?
1. San Joaquin Valley fever
2. desert bumps --> erythema nodosum
3. desert rheumatism --> arthralgias
13
what are the characteristics of chronic phase of the coccidioides pathogenesis?
innate immunity inadequate for clearance, lymphocytes and histiocytes initiate granuloma and giant cell formation
--> If CMI is healthy, infection is contained in granulomas in lung, many eventually cleared asymptomatically
--> many pts who become ill have nonspecific flulike symptoms that resolve at home
14
