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Flashcards in Viral Infection of Upper Resp Tract Deck (38)
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1

how do virons reach respiratory tract?

by fomites or aerosol transmission

2

what is the first site that virus interact with the host?

epithelial cells

3

what cause typical symptoms of viral dz?

fever, aches

4

temp diff between upper and lower resp tract has consequences for pathogenesis such as

1. Rhinoviruses replicate preferentially in URT
2. Differential basis for attenuated viral vaccines

5

what are the 4 virus that prefer the lower reps tract?

1. parainfluenza
2. resp syncytial
3. influenza
4. adenovirus

6

what are the characteristics of coronaviruses?

1. named for their crown spikes
2. negative ssRNA virus
3. caused SARS and MERS

7

what genus belongs to influenzavirus?

orthomyxoviridae

8

where does the replication take place in orthomyxoviridae?

nuclear

9

what is the characteristics of genome of orthomyxoviridae?

segmented negative ssRNA

10

what is the characteristics of genome of paramyxoviridae?

non-segmented negative ssRNA

11

what are the 3 genera of paramyxoviridae?

1. paramyxovirus
2. mumps
3. parainfluenzavirus
4. newcastle dz virus

12

what two virus can cause croup?

parainfluenza virus & RSV

13

what is paramyxoviruses differ from orthomyxoviruses?

1. non-segmented negative sense ssRNA genome
2. little genetics variation

14

what is another name for croup?

laryngotracheobronchitis

15

what season is the peak season for croup?

winter

16

summer time you have a flue what is the most likely causing agent?

adenovirus b/c adenovirus is not seasonal

17

what are the most common cause of virus for common cold?

1. rhinovirus
2. coronavirus
3. influenza virus

18

what cause fever, ashes?

infected epithelial cells release cytokines that cause typical symptoms of viral dz

19

which virus replicate preferentially in URT?

rhinoviruses

20

what are the pattern of infection of
1. picornavirus
2. coronavirus
3. paramyxovirus (parainfluenza and resp syncytial virus)
4. orthomyxovirus (influenza)

acute infection with replication confined to resp mucosal surface

21

3 characteristics of coronaviruses?

1. negative ss RNA virus
2. most cause cold-like symptoms
3. caused SARS and MERS

22

what are the two main animal vectors for coronavirus that caused MERS?

1. bat
2. camel

23

what is the genomic structure of orthomyxoviridae (influenza A, B, C)?

segmented negative ssRNA

24

what is the genomic structure of paramyxoviridae (mumps, parainfluenza, newcastle dz virus)?

non-segmented negative ssRNA

25

what are the main causing agents that hurt you so much when you get a flu?

1. cytokines made from epithelial cells
2. interferon induction
3, T cells response

26

what are major symptoms of flu?

1. high fever
2. headache
3. extreme tiredness
4. cough
5. sore throat
6. runny or stuffy nose
7. body aches
8. diarrhea and vomitting

27

what strain of influenza A we failed to develop vaccine?

H3N2

28

how is paramyxoviruses differ from orthomyxoviruses?

1. non-segmented negative sense ss RNA genome
2. little genetic variation

29

what two strains of virus cause barking cough (croup)?

parainfluenza virus & RSV

30

what are the characteristics of adenovirus?

1. Adenovirus infections are very common, most are asymptomatic
2. Most infections involve the resp or GI tracts or the eyes