QQ Flashcards by Callum McCabe

Antibiotic that reacts dangerously with methotrexate

Trimethoprim

Potentiates folate inhibition

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Electrolyte disturbances in Addison’s disease

Hyponatraemia
Hyperkalaemia

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Initial treatment of Raynaud’s disease (beyond gloves)

Calcium channel blockers e.g. Nifedipine

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Surgical technique to remove basal cell carcinoma in cosmetically sensitive areas

Mohs micrographic surgery

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Positive light bulb sign

Posterior dislocation of shoulder

(can be caused by electrocution)

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Systemic sclerosis antibody

Scl-70 (Anti-toiposomerase 1)
Anti-centromere
Anti-RNA polymerase III

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Rheumatoid arthritis affects which hand joints?

PIPs and MCPs

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Bilateral proximal muscle pain in older patients + sometimes low grade fever, no rise in CK levels

Polymyalgia rheumatica

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Screening test for primary hyperaldosteronism

Aldosterone:renin ratio

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Low gonadotrophins (LH and FSH) resulting in low testosterone production (can cause gynaecomastia)

Hypogonadotrophic hypogonadism

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MOA of carbimazole

Inhibits iodine and TPO

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Pathogen that causes acne

Propionobacterium acnes

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Most common cause of hypothyroidism worldwide

Iodine deficiency

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CREST syndrome a.k.a. ________

LImited cutaneous systemic sclerosis

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CREST syndrome stands for…

Calcinosis
Raynaud’s phenomenon
oEsophageal dysmotility
Sclerodactyly
Telangectasia

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Methotrexate + increasing tiredness =

Folic acid deficiency

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Cranial DI water deprivation test results:

Low after water deprivation, normal after desmopressin

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Nephrogenic DI water deprivation test results:

Low after water deprivation, low after desmopressin

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Finklestein’s test tests for ________

De Quervain’s tenosynovitis

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Condition that often presents with Giant cell arteritis

Polymyalgia rheumatica

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Waterhouse-Friedrichsen syndrome most common cause

Meningitis

Also associated with other bacterial pathogens and splenectomy

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Medication contraindicated with methotrexate

Trimethoprim

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Commonest cause of anovulation in women?

Polycystic ovarian syndrome (PCOS)

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Definitive test for Giant Cell Arteritis

Temporal artery biopsy

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Cause of foot drop

Damage to common peroneal nerve

Treatment for poly/dermatomyositis

High dose corticosteroids which are then tapered down according to CK levels

Clinical test for axillary nerve damage

Test sensation over lower half of deltoid muscle

Lichen planus 6 Ps

Purple Pruritic (itchy) Polygonal (multiple sides) Planar (flat-topped) Papules or Plaques

Tests to monitor methotrexate toxicity

LFTs, renal function, FBC, chest X-ray (to check for pneumonitis)

Bedside test needed for patients with SLE

Urine dipstick to check for lupus glomerulonephritis

Tennis elbow =

Lateral epicondylitis

Golfer's elbow =

Medial epicondylitis

Initial management of DKA

IV 0.9% sodium chloride (saline)

MOA of alendronate (a bisphosphonate)

Inhibits osteoclasts (responsible for bone resorption)

Positive lupus anticoagulant assay =

Antiphospholipid syndrome (can occur secondary to SLE)

Antiphospholipid syndrome - which drug should be avoided?

Combined oral contraceptive pill (COCP)

Swan neck and Boutonniere's deformities

Rheumatoid arthritis

Ophthalmic complication of Giant Cell Arteritis

Anterior ischaemic optic neuropathy

Patients on long-term steroids can develop a 'cushingoid' appearance, with features such as...

Moon face, buffalo hump, central obesity

Antiphospholipid syndrome autoantibodies (3 of them)

Anti-cardiolipin Anti-beta2-GPI Positive lupus anticoagulant assay

Fractures of the humeral shaft damage which nerve?

Radial nerve

Contraindication for alendronic acid

Oesophageal stricture

What test needs to be done at baseline as part of the monitoring protocol for Hydroxychloroquine?

Eye assessment (due to risk of hydroxychloroquine-induced retinopathy

Bilateral phaeochromocytomas can be caused by which condition?

MEN 2B

Why does an urticarial rash occur?

After an allergic reaction

Common rash which often occurs after an upper respiratory tract infection

Pityriasis rosea

Wickham's striae (lacy white lines) on mucosal surfaces

Lichen planus (6 Ps Purple, Pruritic, Papular, Polygonal, Planar)

Which anti-hyperglycaemic drug is most likely to cause a hypoglycaemic event?

Sulphonylureas (e.g. gliclazide)

Notable feature of De Quervain's

Painful thyroid

Before starting biologics, what condition must be screened for?

1st and 2nd line eczema treatment

1. Topical emollient 2. Topical corticosteroid

Reactive overgrowth of capillaries due to minor trauma to fingers. A benign lesion.

Pyogenic granuloma

Abdominal pain + dermatitis herpetiformis (itchy, blistering rash)

Coeliac disease

Dermatomyositis antibodies

Anti-Jo1

Iamotrigine (epilepsy drug) major side effect

Stevens-Johnson Syndrome Presents with systemic upset, mucocutaneous ulceration with skin sloughing. Occurs within 8 weeks drug initiation.

Itchy, red rash with pustules within his pubic hair. STD

Folliculitis

Diagnostic test for dermatomyositis

Muscle biopsy

What is Koebner's phenomenon?

Formation of a skin lesion at a previous injury site

What is Russell's sign?

Scarring of the knuckles. Suggests bulimia

What is Leser-Trelat sign?

Sudden rapid increase in seborrheoic keratoses Commonly caused by malignancy such as gastric adenocarcinoma

First line treatment for seborrheoic keratosis

Removal by cryotherapy, excision, curettage or laser ablation

Staphylococcal Scalded Skin Syndrome affects the oral mucosa. T/F?

False. Toxic Epidermal Necrolysis does.

First line treatment for SSSS

IV flucloxacillin + topical fusidic acid (to target the underlying staph. infection)

Treatment for scabies

Topical permethrin

Skin complication of sarcoidosis

Erythema nodosum

Molluscum contagiosum treatment

Watch and wait (self resolves after 3 months) If removing for cosmetic reasons, perform cryotherapy

Penicillin use + acute skin problems + mouth involvement

Toxic Epidermal Necrolysis

Strep. throat leads to what skin condition?

Guttate psoriasis

Viral infection can lead to what skin condition?

Pityriasis rosea

Dermatophyte fungal skin infections can trigger what skin condition?

Pityriasis versicolor

Treatment for keloid scarring

Intralesional steroids

Treatment for lichen planus

Potent topical steroids e.g. betamethasone