Quiz 1

Question 1

What stays in the bloodstream better?

Answer 1

Hydrophilic

Question 2

what crosses the blood-brain barrier better?

Answer 2

Lipophilic and non-ionized/uncharged

Question 3

Bioavailability of IV, IM, SL

Answer 3

1

Question 4

qualities of drug to pass sublingually

Answer 4

• Lipophilic

- Ionized

Question 5

what characteristic to cross the skin barrier

Answer 5

lipophilic

Question 6

how does tempurature effect topical absorption?

Answer 6

Heat increases absorption

Question 7

rate limits on simple diffusion

Answer 7

• capillary amount
• solubility
• molecular size and composition

Question 8

Compartment 1 of multi compartment model

Answer 8

general circulation

Question 9

compartment 2 of multi-compartment model

Answer 9

Organs

Question 10

Compartment 3 of multi-compartment model

Answer 10

Fatty tissue

Question 11

Hydrophilic drugs tend to stay in which compartment?

Answer 11

compartment 1

Question 12

what is not given to kids without adult teeth?

Answer 12

tetracyclines

Question 13

what type of drug can focus on fetal circulation?

Answer 13

Med with Basic pH

Question 14

drugs that are administered in their non-active form

Answer 14

prodrugs

Question 15

most commonly used target enzyme

Answer 15

CYP3A4

Question 16

Often provides a site for conjugation or may inactivate P450 metabolites for excretion

Answer 16

Hydrolysis

Question 17

Its easier to eliminate which compounds than which compounds?

Answer 17

easier: polar/hydrophilic

Than - Lipophilic

Question 18

3 processes of renal elimination

Answer 18

• Glomerular Filtration
• Active tubular secretion
• Passive tubular reabsorption

Question 19

what med passes via Glomerular filtration?

Answer 19

Unbound meds

Question 20

what med passes via Active tubular secretion?

Answer 20

P-Glycoproteins, and other transport proteins

Question 21

What med passes via passive tubular reabsorption

Answer 21

weak acids/bases via concentration gradients

Question 22

order of kinetics where half life is constant?

Answer 22

First order of kinetics

Question 23

order of kinetics where half life decreases with decreasing concentration

Answer 23

Zero order kinetics

Question 24

Creatinine clearance of someone on HD that day or CRRT

Answer 24

30ml/min

Question 25

Does a loading dose shorten time to steady state?

Answer 25

No, still 4-5 half-lives

Question 26

when the body makes more receptors

Answer 26

upregulation

Question 27

when the body removes receptors

Answer 27

downregulation

Question 28

Drug interaction where P450 enzymes are inhibited or inducted

Answer 28

Altered Metabolism

Question 29

Drug interaction where drugs that bind to plasma proteins may compete with other drugs for the same site

Answer 29

plasma protein competition

Question 30

in plasma protein competition, what can the kicked out competing drug cause?

Answer 30

Toxicity

Question 31

Second messengers/Biochemical messengers:

Answer 31

- cAMP - cGMP - Ca++ - Inositol phosphates