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Systemic Pharmacology II > Quiz 1 Material > Flashcards

Quiz 1 Material Flashcards

1
Q

Propranolol

A

Beta Non-Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

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2
Q

Nitroprusside

A

Parenteral Agents MOA: Causes release of NO with result of increased intracellular cGMP and dilates arterioles and veins

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3
Q

Amlodipine

A

Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax

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4
Q

Dopamine

A

Inotropes (Beta-adrenergic agonists) MOA: Cause positive inotropic effects and vasodilation; increase cAMP which activates protein kinase, and protein kinase increases calcium influx into cells

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5
Q

Acetazolamide

A

Carbonic Anhydrase Inhibitor MOA: Prevent carbonic anhydrase from catalyzing the reaction that form bicarbonate and decrease the kidney’s ability to exchange Na for H

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6
Q

Mannitol

A

Osmotic Diuretics MOA: Filtered through the glomerulus and carries water with them

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7
Q

Metoprolol

A

Beta 1 Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

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8
Q

Moexipril

A

ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)

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9
Q

Isosorbide mononitrate

A

Organic Nitrates MOA: Enzyme activation of drug causes release of NO and NO combines with guanylyl cyclase causing an increase in cGMP

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10
Q

Prazosin

A

Alpha Blockers MOA: Competitive block of alpha 1 receptors to result in a relaxation of arterial and venous smooth muscle. Vasodilation decreases peripheral vascular resistance and decreases BP

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11
Q

Ethacrynic acid

A

Loop Diuretics MOA: Act on the ascending loop of henle; Inhibit cotransport of Na/K/2Cl

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12
Q

Bisoprolol

A

Beta 1 Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

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13
Q

Milrinone

A

Inotropes (Phosphodiesterase inhibitors) MOA: Prevent hydrolysis of cAMP, Increase activity of calcium channel causing greater influx of Ca and also cause vasodilation

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14
Q

Enalapril

A

ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)

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15
Q

Diltiazem

A

Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax

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16
Q

Methazolamide

A

Carbonic Anhydrase Inhibitor MOA: Prevent carbonic anhydrase from catalyzing the reaction that form bicarbonate and decrease the kidney’s ability to exchange Na for H

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17
Q

Acebutolol

A

Beta 1 Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

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18
Q

Fenoldopam

A

Parenteral Agents MOA: Peripheral dopamine-1 receptor agonist Relaxes mainly the renal and mesenteric arterial vessels and increases renal blood flow

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19
Q

Eprosartan

A

Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels

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20
Q

Hydralazine

A

Vasodilators MOA: Releases NO

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21
Q

Isosorbide dinitrate

A

Organic Nitrates MOA: Enzyme activation of drug causes release of NO and NO combines with guanylyl cyclase causing an increase in cGMP

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22
Q

Bumetanide

A

Loop Diuretics MOA: Act on the ascending loop of henle; Inhibit cotransport of Na/K/2Cl

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23
Q

Esmolol

A

Beta 1 Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin

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24
Q

Nitroglycerin

A

Organic Nitrates MOA: Enzyme activation of drug causes release of NO and NO combines with guanylyl cyclase causing an increase in cGMP

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25
Benazepril
ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)
26
Felodipine
Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax
27
Ranolazine
Sodium (NA) Channel MOA: Inhibits the late phase of the Na current, and reduces intracellular sodium and calcium overload Improves diastolic function
28
Dobutamine
Inotropes (Beta-adrenergic agonists) MOA: Cause positive inotropic effects and vasodilation; increase cAMP which activates protein kinase, and protein kinase increases calcium influx into cells
29
Indapamide
Thiazide Diuretics MOA: Act on the distal convoluted tubule; Inhibits the Na/Cl co-transporter
30
Irbesartan
Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels
31
Labetalol
Beta Non-Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin
32
Clonidine
Centrally-acting Alpha-2 Agonists MOA: Decrease sympathetic output and reduces NE release
33
Azilsartan
Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels
34
Trandolapril
ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)
35
Verapamil
Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax
36
Valsartan
Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels
37
Captopril
ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)
38
Telmisartan
Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels
39
Nisoldopine
Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax
40
Quinapril
ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)
41
Clevidipine
Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax
42
Chlorthalidone
Thiazide Diuretics MOA: Act on the distal convoluted tubule; Inhibits the Na/Cl co-transporter
43
Doxazosin
Alpha Blockers MOA: Competitive block of alpha 1 receptors to result in a relaxation of arterial and venous smooth muscle. Vasodilation decreases peripheral vascular resistance and decreases BP
44
Ramipril
ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)
45
Cilazapril
ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)
46
Atenolol
Beta 1 Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin
47
Carvedilol
Beta Non-Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin
48
Nebivolol
Beta 1 Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin
49
Nicardipine
Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax
50
Metolazone
Thiazide Diuretics MOA: Act on the distal convoluted tubule; Inhibits the Na/Cl co-transporter
51
Isradipine
Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax
52
Epleronone
Potassium-Sparing Diuretics MOA: Act on the collecting tubule/duct; Blocks aldosterone receptors and prevents production of proteins that stimulate Na/K exchange sites of the collecting tubules
53
Minoxidil
Vasodilators MOA: Hyperpolarizes smooth muscle by opening potassium channels
54
Inamrione
Inotropes (Phosphodiesterase inhibitors) MOA: Prevent hydrolysis of cAMP, Increase activity of calcium channel causing greater influx of Ca and also cause vasodilation
55
Aliskiren
Renin Inhibitor MOA: Directly inhibits renin
56
Terazosin
Alpha Blockers MOA: Competitive block of alpha 1 receptors to result in a relaxation of arterial and venous smooth muscle. Vasodilation decreases peripheral vascular resistance and decreases BP
57
Fosinopril
ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)
58
Spironolactone
Potassium-Sparing Diuretics MOA: Act on the collecting tubule/duct; Blocks aldosterone receptors and prevents production of proteins that stimulate Na/K exchange sites of the collecting tubules
59
Furosemide
Loop Diuretics MOA: Act on the ascending loop of henle; Inhibit cotransport of Na/K/2Cl
60
Nifedipine
Calcium Channel Blockers MOA: Prevent inward movement of Ca and causes muscle to relax
61
Digoxin
Inotropes (Cardiac glycosides) MOA: Inhibits the ability of the monocyte to actively pump Na from the cell
62
Hydrochlorothiazide (HCTZ)
Thiazide Diuretics MOA: Act on the distal convoluted tubule; Inhibits the Na/Cl co-transporter
63
Lisinopril
ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)
64
Torsemide
Loop Diuretics MOA: Act on the ascending loop of henle; Inhibit cotransport of Na/K/2Cl
65
Nadolol
Beta Non-Selective Blockers MOA: Lower BP mainly by decreasing cardiac output, also decrease sympathetic outflow from CNS and inhibit release of renin
66
Perindopril
ACE Inhibitors MOA: Prevent the conversion of angiotension I to angiotension II and Increase levels of bradykinin (vasodilator)
67
Losartan
Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels
68
Olmesartan
Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels
69
Methyldopa
Centrally-acting Alpha-2 Agonists MOA: Decrease sympathetic output and reduces NE release
70
Candesartan
Angiotension-Receptor Blockers MOA: Blocks Angiotension II from binding to its receptor and thus blocking its action, BUT DOES NOT increase bradykinin levels

Systemic Pharmacology II (5 decks)

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