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Flashcards in Quiz 2 Deck (124)
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1

What analgesics activate the mu receptors and exert a weak activation of kappa receptors:

Opioids: morphine/codeine; controlled substances

2

Activation of what receptor will lead to respiratory depression, euphoria, sedation, analgesia:

mu receptors

3

Activation of what receptor leads to sedation and analgesia:

Kappa receptors

4

What are the two isomers that opioids have:

levo and dextro

5

what isomer has an analgesia effect

levo

6

What isomer has an antitussive effect:

levo and dextro

7

Which isomer causes physical dependence:

levo

8

What are the characteristics of opioid isomers:

3 A: analgesia, antitussive (medulla), antidiarrheal; suppressed RR (medulla)

9

What is given to treat moderate/severe acute/chronic pain; pre-op; or dyspnea d/t ventricular failure and PE:

opioids (indications)

10

Would you give opioids to pts w/head injuries:

No

11

Would you give opioids to asthmatic pts:

No

12

Would you give opioids to pts w/hypotension:

No

13

Would you give opioids to pts in labor or delivery of pre-mis:

No

14

Would you give opioids to renal or hepatic impairment pts:

No

15

What are the side effects d/t opioids:

orthostatic hypotension; N/V/constipation; Drowsiness/sedation/confusion; and urinary retention

16

What is a S/S of opioids toxicity:

pupillary constriction

17

What are the ADVERSE effects d/t opioids:

RR depression (<10); hypotension, P. constriction; tolerance/physical dependance; withdrawal syndrome

18

What drugs can increase the effect of opioids:

EtOH; sedative-hypnotics; antipsychotic; muscle relaxants

19

What are the nemonics for common opioids:

Drugs ending w/ONE (phone/done), MFM: morphine, fentanyl, meperidine

20

What is the onset of morphine sulfate when given parenterally:

Rapid especially if it's IV

21

What is the duration of morphine sulfate:

3-5 hrs

22

What is the duration of morphine sulfate controlled release:

8-12 hr

23

If a pt has severe pain, how is morphine sulfate given:

IV

24

What are the pharmocokinetics of morphine sulfate:

liver metabolizes; sm amount crosses BBB; 90% is excreted = short half-life; crosses placenta/breast milk

25

If you were giving morphine sulfate PO, what is the normal dose:

10-30 mg q 4 hr

26

If you were giving morphine sulfate SQ/IM, what would the dose be:

5-15 mg q 4 hr

27

If you were giving Morphine sulfate IV, what would the dose be:

4-10 mg q 4 hrs

28

Would you give an higher dose of morphine sulfate/opioids PO or parenterally:

PO (d/t 90 being excreted)

29

What is the assessment process when giving opioids:

RR (asthma), PMH (liver), drug hx, VS/RR, I &Os; pain amount

30

Incase of a Morphine sulfate overdose, what med is giving to counteract it:

Narcan (Naloxone)