Quiz 3 Flashcards Preview

x SCO summer 2015 Pharmacology > Quiz 3 > Flashcards

Flashcards in Quiz 3 Deck (72):
1

Minocycline

PSI, Tetracycline. reversibly binds to 30s ribo. subunit preventing tRNA binding--translation stops.

2

Valacyclovir (Valtrex)

Herpesvirus drug.?Guanosine analog gets incorporated into viral DNA via DNA poly

3

Cycloserine

Second-line antimycobacterial. Inhibits cell wall synthesis

4

Caspofungin

Antifungal, Echinocandin. lyses cell wall.

5

Fidaxomicin

PSI, Macrolide/Ketolide. Binds to 50s ribo. subunit (can inhibit its formation) to block peptidyltransferasecenter to prevent AA elongation.

6

Fluconazole

Antifungal, Azole. Inhibits P450 enzyme that converts lanosterol to ERGOSTERL, disrupting fungal membrane.

7

Dapsone

Antimicobacterial, Leprosy drug. Inhibits folate synthesis.

8

Linezolid

PSI, "other". binds to 50s subunit to inhibit ribosome complex formation.

9

Isoniazid

First-line antimycobacterial. Prodrug gets converted and blocks mycolic acid production

10

Famciclovir

Herpesvirus drug. ?Guanosine analog gets incorporated into viral DNA via DNA poly

11

Trimethoprim

Antifolate. Inhibits dehydrogolate reductase, preventing dihydrofolic to tetra

12

Amantadine

Respiratory flu drug. inhibits viral uncoating. Blocks viral membrane matrix protein M2 so viral and host membrane can't fuse.

13

Azithromycin (Zithromax, Zpak)

PSI, Macrolide/Ketolide. Binds to 50s ribo. subunit (can inhibit its formation) to block peptidyltransferasecenter to prevent AA elongation.

14

Micafungin

Antifungal, Echinocandin. lyses cell wall.

15

Acyclovir

Herpesvirus drug. Guanosine analog gets incorporated into viral DNA via DNA poly

16

Nitrofurantoin

Urinary Tract Antiseptic. bacteria makes drug a toxic intermediate that damages their DNA

17

Cotrimoxazole (Bactrim)

Antifolate. Trimethoprim + Sulfamethoxazole

18

Tobramycin

PSI Aminoglycoside. Binds to 30s ribo subunit preventing protein synthesis initiation AND cause misreading of mRNA causing wrong AA insertion.

19

Doxycycline

PSI, Tetracycline. reversibly binds to 30s ribo. subunit preventing tRNA binding--translation stops.

20

Norfloxacin

2nd line antimycobacterial and 2nd Gen Flouroquinolone. Enters bacteria via diffusion; uses dual mechanism to inhibit DNA gyrase and topoisomerase IV.

21

Flucytosine

Antifungal, "Other". drug enters fungal cell and is converted into the antimetabolite 5-FU

22

Amphotericin B

Antifungal, Polyene Antibiotic. binds to ergosterol in membrane making ion pore > death.

23

Ethionamide

Second-line antimycobacterial. Prodrug gets converted and blocks mycolic acid production

24

Ketoconazole

Antifungal, Azole. Inhibits P450 enzyme that converts lanosterol to ERGOSTERL, disrupting fungal membrane.

25

Moxifloxacin

2nd line ANTIMYCOBACTERIAL and 4nd Gen Flouroquinolone. Enters bacteria via diffusion; uses dual mechanism to inhibit DNA gyrase and topoisomerase IV.

26

Pyrazinamide

First-line antimycobacterial. Inhibits growth by lowering intracellular pH

27

Posaconazole

Antifungal, Azole. Inhibits P450 enzyme that converts lanosterol to ERGOSTERL, disrupting fungal membrane.

28

Ribavirin

Viral Hepatitis drug. guanosine analog causes dec guanosine triphosphate, blocking DNA/RNA synthesis.

29

Neomycin

PSI Aminoglycoside. Binds to 30s ribo subunit preventing protein synthesis initiation AND cause misreading of mRNA causing wrong AA insertion.

30

Ethambutol

First-line antimycobacterial. interferes with cell wall synthesis

31

Rimantadine

Respiratory flu drug. inhibits viral uncoating. Blocks viral membrane matrix protein M2 so viral and host membrane can't fuse.

32

Capreomycin

Second-line antimycobacterial. Inhibits protein synthesis

33

Oseltamivir (Tamiflu)

Respiratory flu drug. Inhibits neuraminidase, kills virus.

34

Ofloxacin

2nd line antimycobacterial and 2nd Gen Flouroquinolone. Enters bacteria via diffusion; uses dual mechanism to inhibit DNA gyrase and topoisomerase IV.

35

Itraconazole

Antifungal, Azole. Inhibits P450 enzyme that converts lanosterol to ERGOSTERL, disrupting fungal membrane.

36

Rifapentine

First-line antimycobacterial. inhibits RNA polymerase to prevent transcription.

37

Ganciclovir

Cytomegalovirus drug. Guanosine analog gets incorporated into viral DNA via DNA poly.

38

Gemifloxacin

2nd line antimycobacterial and 4nd Gen Flouroquinolone. Enters bacteria via diffusion; uses dual mechanism to inhibit DNA gyrase and topoisomerase IV.

39

Telithromycin

PSI, "Ketolide". Binds to 50s ribo. subunit (can inhibit its formation) to block peptidyltransferasecenter to prevent AA elongation.

40

Trifluridine (Viroptic)

Herpesvirus drug. Flourinated pyrimidne nucleotide inhibits incorporatation of thymide triphosphate into viral DNA ; drug also incoporates into viral DNA.

41

Chloramphenicol

PSI, "other". binds to 50s ribo subunit to inhibit pepbide bond formation.

42

Erythromycin

PSI, Macrolide/Ketolide. Binds to 50s ribo. subunit (can inhibit its formation) to block peptidyltransferasecenter to prevent AA elongation.

43

Streptomycin

Second-line antimycobacterial aminoglycoside. MoA not given.

44

Tetracycline

PSI, Tetracycline. reversibly binds to 30s ribo. subunit preventing tRNA binding--translation stops.

45

Sulfadiazine

Antifolate. Prohibits bacterial production of folate becasuse drug is PABA analogue and competes with dihydropteroate synthetase.

46

Rifabutin

First-line antimycobacterial. inhibits RNA polymerase to prevent transcription.

47

Clindamycin

PSI, "other". Binds to 50s ribo. subunit (can inhibit its formation) to block peptidyltransferasecenter to prevent AA elongation.

48

Boceprevir

Viral Hepatitis drug. Bind to active site of HCV protease

49

Levofloxacin (Levaquin)

2nd line ANTIMYCOBACTERIAL and 3nd Gen Flouroquinolone. Enters bacteria via diffusion; uses dual mechanism to inhibit DNA gyrase and topoisomerase IV.

50

Sulfamethoxazole

Antifolate. Prohibits bacterial production of folate becasuse drug is PABA analogue and competes with dihydropteroate synthetase.

51

Lamivudine

Viral Hepatitis drug. inhibits HBV DNA poly and HIV rev transcriptase.

52

Anidulafungin

Antifungal, Echinocandin. lyses cell wall.

53

Interferon

Viral Hepatitis drug. MoA poorly known: inhibit viral RNA tranlsation

54

Clarithromycin

PSI, Macrolide/Ketolide. Binds to 50s ribo. subunit (can inhibit its formation) to block peptidyltransferasecenter to prevent AA elongation.

55

Cidofovir

Cytomegalovirus drug. cytosine analog inhibits DNA synthesis wo/ need of viral enzymes.

56

Ciprofloxacin (Cipro)

2nd line ANTIMYCOBACTERIAL and 2nd Gen Flouroquinolone. Enters bacteria via diffusion; uses dual mechanism to inhibit DNA gyrase and topoisomerase IV.

57

Tenofovir

Viral Hepatitis drug. nucleotide analog inhibits viral reverse transcriptase.

58

Voriconazole

Antifungal, Azole. Inhibits P450 enzyme that converts lanosterol to ERGOSTERL, disrupting fungal membrane.

59

Tigecycline

PSI, "Tetracycline"; actually a glycylcycline. reversibly binds to 30s ribo. subunit preventing tRNA binding--translation stops.

60

Clofazimine

Antimicobacterial, Leprosy drug. binds to DNA to prevent using it as a template for replication

61

Nystatin

Antifungal, Polyene Antibiotic. binds to ergosterol in membrane making ion pore > death.

62

Zanamivir

Respiratory flu drug. Inhibits neuraminidase, kills virus.

63

Methenamine

Urinary Tract Antiseptic. Makes formaldehyde at low 5.5 pH

64

Amikacin

PSI Aminoglycoside. Binds to 30s ribo subunit preventing protein synthesis initiation AND cause misreading of mRNA causing wrong AA insertion.

65

Griseofulvin

Antifungal, "Other". Inhibits fungal mitosis until skin sloughs it off.

66

Gentamicin

PSI Aminoglycoside. Binds to 30s ribo subunit preventing protein synthesis initiation AND cause misreading of mRNA causing wrong AA insertion.

67

Sulfacetamide

Antifolate. Prohibits bacterial production of folate becasuse drug is PABA analogue and competes with dihydropteroate synthetase.

68

Terbinafine

Antifungal, "Other". Squalene builds up becuase drug prevents conversion into ergosterl by inhibiting squalene epoxidase

69

Demeclocycline

PSI, Tetracycline. reversibly binds to 30s ribo. subunit preventing tRNA binding--translation stops.

70

Macrolides

Second-line antimycobacterial and PSI. Binds to 50s ribo. subunit (can inhibit its formation) to block peptidyltransferasecenter to prevent AA elongation.

71

Rifampin

First-line antimycobacterial. inhibits RNA polymerase to prevent transcription.

72

Telaprevir

Viral Hepatitis drug. Bind to active site of HCV protease