Quiz 3 Cholesterol Synthesis Flashcards
Nearly all tissues can synthesize cholesterol from what?
20% of cholesterol synthesis happens where?
In the liver
Extrahepatic sites cholesterol can be synthesized?
Intestine, adrenal cortex, reproductive tissues
Chylomicron remnants go to where and converted to bile salts?
Free cholesterol is an essential component of what?
cell membranes (this regulates the fluidty, gives strength to the membrane)
Free cholesterol is precursor to?
bile salts and steroid hormones
Type of cholesterol not located in membranes and is MORE hydrophobic?
What are two outcomes of excess cholesterol?
Gallstones and Atherosclerosis (cholesterol deposited at the linings of blood vessels)
30% of circulating cholesterol is this form?
Cholesterol Synthesis occurs where in the cell?
Reducing power of cholesterol synthesis?
What things are required in cholesterol synthesis?
ATP, molecular O2, Acetyl CoA
What are the 3 stages of cholesterol synthesis?
Stage 1: 3 Acetyl CoA → HMG-COA
Stage 2: HMG-CoA → Mevalonic Acid (mevalonate) → Squalene
Stage 3: Squalene → Cholesterol
What is the rate-limiting, key regulatory step of cholesterol synthesis?
HMG-CoA reductase (remember this occurs in the cytosol)
Product of HMG-CoA Reductase?
Mevalonate (mevalonic acid)