Quiz 6 Reverse

Question 1

1. Impaired memory2. Disorientation3. Language difficulties4. Impaired judgement

Answer 1

Cognitive Sx of Alzheimers

Question 2

1. Agitation2. Anxiety3. Psychosis4. Depression

Answer 2

Non-cognitive Sx of Alzheimers

Question 3

1. Exelon2. Aricept3. Razadyne Tries to preserve as much ACh as possible Used for AlzeihmersAvoid in Pts w/ CV disease, peptic ulcer disease Don’t use w/ anticholinergics

Answer 3

Name the antichonlinesterases

Question 4

1. Nausea2. Insomnia3. HA4. Blurred vision 5. Bradycardia6. Syncope

Answer 4

ADRs anticholineresterases

Question 5

1. NamendaDec. [glutamate], cuts down flow of Ca2+ to dec. cellular damageFor AlzheimersMay be neuroprotective Dose for renal impairment

Answer 5

What is the NMDA receptor antagonist & how does it work?

Question 6

NMDA receptor antagonist1. Ataxia, hypokinesia2. Emotional agitation, confusion, dizziness, depression, fatigue3. Constipation

Answer 6

ADRs Namenda

Question 7

1. Inc. amount of dopamine in CNS2. Dec. ACh levels or block ACh

Answer 7

Goals of Parkinson therapy

Question 8

WithdrawalNMS - Neuroleptic Malignant Syndrome

Answer 8

What risk comes from stopping Dopamine precursors?

Question 9

1. Mirapex2. Requip3. RotigotineParkinson’s drug

Answer 9

What are the dopamine agonists?

Question 10

Levodopa/CarbidopaCarbidopa is smaller #

Answer 10

What are the dopamine precursors?

Question 11

More likely to have side effects than dopamine precursor1. Inducing compulsive behavoir2. Postural HOTN3. Hallucinations4. Nausea5. Somnolence6. Worsen diskenesias

Answer 11

ADRs dopamine agonists

Question 12

1. Rasagiline2. SelegelineReduce the breakdown of dopamine

Answer 12

What are the MAO-B inhibitors?

Question 13

Amantadine Renally adjustedGood for rigidityAnkle edema, liedo reticularis

Answer 13

What is a good add-on therapy for advanced Parkinson’s?

Question 14

1. Cogentin2. ArtaneParkinson’sGood for slow, resting tremor

Answer 14

What are the anticholinergics?

Question 15

1. Tasmar2. ComtanUse w/ Levodopa/carbidopa

Answer 15

What are the COMT inhibitors and when are they used?

Question 16

Thorazine

Answer 16

What antipsychotic is used for hiccups?

Question 17

Typical antipsychotics1. Thorazine2. Prolixin3. TrilafonBlocks D2 & D1

Answer 17

What are the phenothiazines?

Question 18

1. QTc prolongation2. Hyperprolactinemia3. Wt gain4. Tachycardia5. Dizziness6. HOTN7. Impotence 8. Akathisia & distonias 9. Parkinsonian syndrome

Answer 18

ADRs phenothiazines

Question 19

Abilify Strong D2 blockade & serotonin

Answer 19

Which antipsychotic can you use in kids?

Question 20

ex. Abilify1. Wt gain2. Hyperlipidemia3. Hyperglycemia4. Prolactin elevation5. Seizures6. Orthostatic HOTN7. NMS8. QTc prolongation9. Sudden death

Answer 20

Side effects of 2nd Gen antipsychotics

Question 21

1. Tranylcypromine2. Isocarboxazid3. Phenelzine4. Selegeline Don’t eat tyramine!

Answer 21

What are the MAOIs?

Question 22

1. Nortriptyline - 2 amine2. Amitriptyline - 3 amineUse Nortriptyline in old people

Answer 22

What are the tricyclic antidepressants?

Question 23

1. Sedation2. Postural HOTN3. Blurred vision, dry mouth, constipation4. Arrythmias, sinus tachycardia, QTc prolongation

Answer 23

ADRs tricyclic antidepressants

Question 24

1. Inc. fall risk2. Lower bone mineral density3. Sexual dysfunction4. SIADH5. Constitutional Sx Probably safe in pregnancy

Answer 24

ADRs SSRI

Question 25

1. Sertarline2. Bupropion3. Citalopram

Answer 25

What are the preferred antidepressants in old people?

Question 26

1. Xanax2. Valium3. Ativan Schedule IV drugs

Answer 26

What are the benzodiazepines?

Question 27

BuspironeNo abuse potential

Answer 27

What is the non-benzo for anxiety?

Question 28

1. Renally dosed2. Affected by thiazide diuretics, NSAIDs3. Monitor blood levels - 0.4-1.2Toxic at 1.54. Polyuria & polydipsia 5. Thyroid enlargement6. Tremor, EEG changes

Answer 28

ADRs lithium salts

Question 29

DepakoteUsed for seizures & bipolar disorder Polycystic ovarian syndrome risk Life-threatening pancreatitis

Answer 29

What is the valproic acid derivative?

Question 30

For bipolarEquetro CYP3A4 substrateStrong inducer of CYP2C19, CYP3A4 & P-glycoprotein

Answer 30

What is the anticonvulsant?

Question 31

1. Ataxia, dizziness, HA2. Hematologic - agranulocytosis, aplastic anemia, leukopenia3. SJS

Answer 31

ADRs equetro?