Rest for final!!!!!

Question 1

Cyclobenzaprine

Answer 1

Skeletal muscle relaxant

Risk of serotonin syndrome & cardiac side effects

Caution w/ hepatic impairment

Question 2

Diazepam

Answer 2

Skeletal muscle relaxant

Facilitates GABA action in CNS

Sedation & dependence potential

Question 3

Baclofen

Answer 3

Skeletal muscle relaxant
Works on GABA in brain & spinal cord

Less sedating than diazepam

ADRs
Drowsiness, inc. seizure activity
Withdrawal can be life-threatening

Question 4

Tizanidine

Answer 4

Skeletal muscle relaxant
Presynaptic & postsynaptic inhibition in spinal cord

ADRs
Drowsiness & dizziness
HOTN, asthenia & hepatotoxicity

MANY drug rxns

Question 5

Botulinum toxin

Answer 5

Skeletal muscle relaxant

Inhibition of ACh release at neuromuscular junction
Inject directly into muscle

ADRs
Local hematoma, fatigue, dizziness, pain in neighboring muscles

Question 6

What are the skeletal muscle relaxants?

Answer 6

1. Diazepam
2. Baclofen
3. Tizanidine
4. Botulinum toxin
5. Cyclobenzaprine

Question 7

Which psychostimulant avoids the 1st pass effect?

Answer 7

Daytrana

ADHD med

Question 8

Which psychostimulant is a prodrug?

Answer 8

Vyvanse

for ADHD

Question 9

Which ADHD drug is weight based?

Answer 9

Strattera

Major 2D6 substrate

Delay in onset compared to psychostimulant

Question 10

Which ADHD drugs should you not stop abruptly?

Answer 10

1. Guanfacine

2. Clonidine

Question 11

ADRs ADHD drugs

Answer 11

1. Irritability, aggression, mania
2. Dysphoria, zombie state
3. Hallucinations
4. Anorexia
5. Stomach pain

Question 12

Schedule I drugs

Answer 12

Can’t be prescribed - no medical use

1. Heroin
2. MDMA
3. LSD
4. Weed
5. Gamma hydroxybutyrate
6. Morpheridine

Question 13

Schedule II drugs

Answer 13

High abuse potential

1. Opiates
2. Stimulants - dextroamphetamine, methylphenidate
3. Depressants - secobarbital, pentobarbital, glutethimide
4. Precursors of Schedule I drugs

Question 14

Schedule III drugs

Answer 14

Psychological dependence & maybe physical dependence

1. Stimulants
2. Depressants
3. Opiod combinations
4. Anabolic steroids
5. Weed derivatives - Dronabinol

Question 15

Schedule IV drugs

Answer 15

Dependence likely

1. Depressants - Benzos, some barbiturates, sleep aids
2. Stimulants - modafinil, phentermine
3. Analgesics - Pentazocine, butorphanol

Question 16

Schedule V drugs

Answer 16

1. Opiates - codeine containing cough syrup
2. Pregabalin, ezogabine, lacosamide
3. Ephedrine-containing products