Random Flashcards

(37 cards)

1
Q

What is the causative agent of Lyme disease?

A

Bacteria

Borrelia burgdorferi

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2
Q

What is the causative agent of Q-fever?

A

Bacteria

Coxiella burnetii

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3
Q

What is the causative agent of Bovine TB?

A

Bacteria

Mycobacterium Tuberculosis

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4
Q

How to calculate Positive Predictive Value?

A

True positive / true positive + false positive

x100

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5
Q

What does a drop in positive predictive value mean?

A

The prevalence of the disease has decreased

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6
Q

What is sensitivity?

A

True positive

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7
Q

What is specificity?

A

True negative

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8
Q

How do we calculate the sensitivity?

A

True positive / true positive + false negative

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9
Q

How do we calculate the specificity?

A

True negative/true negative + false positive

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10
Q

What is Selection Bias?

A

Error that occurs when the participants in a study are not representative of the target population

E.g. choosing a group, not randomised

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11
Q

What is Information bias?

A

Error in the collection of data

Differences in the way the researchers collect the data or incorrect classification

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12
Q

What is external validity?

A

The extent at which a study can be generalised to a wider group e.g. nationwide, worldwide etc

E.g. if a drug was only tested on young healthy people its external validity may be low - may not apply to elderly or ill.

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13
Q

How do you calculate contact rate?

A

R0 / duration of infectiousness

e.g R0 = 2, infectious for 10 days
Contact rate = 2 / 10 = 0.2

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14
Q

How do you calculate R0?

A

Contact rate x duration of infectiousness

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15
Q

What happens to PPV when prevalence decreases?

A

It also decreased

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16
Q

How to calculate total benefits?

A

Money you get per unit

e.g. Price paid to you per kg of meat e.g. 2.33 £/Kg

17
Q

How to calculate total costs?

A

Cost to buy * number of units + production costs per kilogram

e.g. £180 (cost to buy) * number of units + (£1.93/kg * liveweight kg)

18
Q

How to calculate marginal benefit?

A

Benefit from the current unit - benefit from the unit before (n-1)

19
Q

How to calculate marginal cost?

A

Cost from current unit - cost from the unit before (n-1)

20
Q

How to calculate net benefit?

A

Total benefit - total cost

21
Q

What is the Global Burden of animal disease approach to estimate the impact of disease?

A

Global burden of animal diseases (GBADs) approach calculating an
The animal health loss envelope compares a diseased production with an optimal or utopian production without disease.

22
Q

What is the economic impact framework according to Rushton to estimate the impact of disease?

A

Economic impact framework according to Rushton that compares losses and expenditures broken down into visible and invisible losses and additional costs and revenue foregone.

23
Q

What is the Economic impact framework according to Bennett to estimate the impact of disease?

A

Economic impact framework according to Bennett that compares losses and expenditures whereas the impact is a combination of losses plus increase in expenditures plus costs of inputs and costs of disease
prevention measures plus human impact and animal welfare score.

24
Q

What are some examples of externalities?

A

Environmental pollution:
* Runoff of nutrients, pathogens, and chemicals from poultry farms into
water bodies.
* Water pollution, eutrophication, and contamination of local ecosystems,
affecting aquatic life and water quality.

Airborne emissions:
* Emission of dust, particulate matter, and ammonia from broiler houses.
* Air pollution in the surrounding area, potentially leading to respiratory issues in humans and animals.

Odour emissions:
* Release of unpleasant odours from poultry farms.
* Odour nuisance for nearby residents, affecting their quality of life and well-being.

Noise pollution:
* Noise generated by equipment, fans, and activities on poultry farms.
* Disruption to the peace and quiet of the surrounding community,
potentially causing stress and annoyance.

Antibiotic resistance:
* Use of antibiotics in poultry production leading to the development of
antibiotic-resistant bacteria.
* Increased risk of antibiotic-resistant infections in humans, affecting
public health.

Disease transmission:
* Outbreak of animal disease affecting other farms
* Disease impact as described above causing costs and losses

25
What is a case-control study?
Retrospective Looks at cases (of disease) and control groups (without disease) and looks at potential exposures in the past that led to the disease E.g. Lung cancer Group of people with lung cancer Group of people without lung cancer Which of them smoked in the past
26
27
What are cohort studies?
A group of individuals (a cohort) are followed over time Specific exposure Grouped into exposed and unexposed, then followed over time
28
What are cohort studies useful for?
Establishing a temporal relationship between exposure and outcome Studying multiple outcomes Can establish risk and incidence
29
What are the disadvantages of cohort studies?
Time-consuming and expensive Not ideal for rare diseases Susceptible for loss to follow-up which can affect results
30
What are the disadvantages of case-control studies?
Information bias can be common Cannot directly calculate incidence or risk Selection of appropriate controls can be difficult
31
What is a cross-sectional study?
Measures exposure and outcome at the same time E.g. surveys to see if people are currently smoking and if they have high blood pressure Snapshot of exposure and outcome at the same point in time
32
What are the advantages of a cross-sectional study?
Quick and relatively cheap Useful for measuring disease burden and identifying health needs
33
What are the disadvantages of a cross-sectional study?
Cannot tell whether exposure preceded the disease May miss short term or rare outcomes
34
What are randomised controlled trials (RCTs)?
A Randomised Controlled Trial is an experimental study where participants are: Randomly assigned to one or more intervention groups (e.g. receive a new drug) or a control group (e.g. receive a placebo or standard treatment). Followed over time to compare outcomes between groups.
35
What are the advantages of RCTs?
Reduces bias Highest level of evidence for causal inference Can precisely measure the treatment effect
36
What are the disadvantages of RCTs?
Expensive and time consuming May have ethical limitations May not be generalised
37
What is Cost-Effectiveness Analysis?
Cost of intervention / effectiveness E.g. drug A costs £1000 and adds 1.5 QALYs drug B costs £2000 and adds 2 QALYs 2000-1000 / 0.5 (2-1.5) = £2000 per QALY