rate determining enzymes of metabolic processes Flashcards Preview

Boards microbio and biochem > rate determining enzymes of metabolic processes > Flashcards

Flashcards in rate determining enzymes of metabolic processes Deck (14):
1

glycolysis (for this and all, name the enzyme and the regulators)

PFK-1.
incr.: AMP, fructose-2,6-bisphosphate
decr.: ATP, citrate

2

gluconeogenesis

fructose-1,6-bisphosphatase
incr.: ATP, acetyl CoA
decr. AMP, fructose-2,6-bisphosphatase

3

TCA cycle

isocitrate dehydrogenase
incr. by ADP
decr. by ATP and NADH

4

glycogenesis

glycogen synthesis.
incr. by glucose-6-P, insulin, cortisol.
decr. by epinephrine, glucugon

5

glycogenolysis

glycogen phosphorylase
incr. by epinephrine, glucagon, AMP
decr. by glucose-6-P, insulin, ATP

6

HMP shunt

glucose-6-phosphate dehydrogenase.
incr. by NADP. decr. by NADPH

7

de novo pyrimidine synthesis

carbamoyl phosphate synthetase II

8

de novo purine synthesis

PRPP amidotransferase
(glutamine-phosphoribosylpyrophosphate amidotransferase)
decr. by AMP, IMP (inosine monophosphate), and GMP

9

urea cycle

carbamoyl phosphate synthestase I
incr. by N-acetylglutamate

10

fatty acid synthesis

acetyl-CoA carboxylase
incr. by insulin and citrate
decr by glucagon and palmitoyl-CoA

11

ketogenesis

HMG-CoA synthetase

12

cholesterol synthesis

HMG-CoA reductase
incr. by insulin and thyroxine
decr. by glucagon and cholesterol

13

fatty acid oxidation

carnitine acyltransferase I
incr. by malonyl-CoA

14

production of pyruvate

pyruvate kinase (from phosphoenolpyruvate)
incr. by fructose 1,6-BP
decr. by ATP and alanine (which builds up when pyruvate decarboxylase is deficient, so it probably suggests too much alanine around)