Regulators Of Complement Activation Flashcards Preview

Pharm 413 Drugs > Regulators Of Complement Activation > Flashcards

Flashcards in Regulators Of Complement Activation Deck (7)
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1

C1 inhibitor (C1 INH)

Interacts with: C1r, C1s

Function: Binds to C1r and C1s and dissociates them from C1q. This prevents activation and cleavage of C4 or C2

2

Factor I

Interacts with C4b, C3b

Function: cleaves C3b and C4b by using factor H, MCP, C4BP or CR1 as cofactors

3

Factor H

Interacts with: C3b

Function: Binds to C3b and displaces Bb.
Cofactor for factor I- meditated cleavage of C3b

4

C4-binding protein (C4BP)

Interacts with: C4b

Function: Binds to C4b and displaces C2a.
Cofactor for factor I-mediated cleavage of C4b

5

Membrane cofactor for protein (MCP)

Interacts with: C3b, C4b


Function: cofactor for factor I-mediated cleavage of C3b and C4b

6

Decay-accelerating factor (DAF)

Interacts with: C4b2a and C3bBb

Function: Displaces 2a from C4b, and Bb from C3b (dissociation of C3 convertases)

7

CD59

Interacts with: C7, C8

Function: locks C9 binding and prevents formation of the MAC