Renal 3

Question 1

Infection assd with cryoglobulinemia

Answer 1

Hep C

Question 2

Most frequent GN worldwide

Answer 2

IgA nephropathy

Question 3

Location of staining in IgA nephropathy

Answer 3

mesangium

Question 4

This helps differentiate IgA nephropathy from lupus

Answer 4

C1q is pos in lupus, neg in IgA

Question 5

Class 1 and 2 lupus

Answer 5

Class 1: normal histology

Class 2: mesangial lesion

Question 6

Class 3 and 4 lupus

Answer 6

Class 3: focal proliferative GN

Class 4: diffuse proliferative GN

Question 7

Class 5 lupus

Answer 7

membranous nephropathy

Question 8

Most common and most severe lupus

Answer 8

class 5

Question 9

differential of crescentic GN (3)

Answer 9

Immune-complex mediated,
Pauci-immune,
Anti-GBM

Question 10

Pauci-immune crescentic GN usually assd with..

Answer 10

ANCA

Question 11

Most common ANCA in microscopic polyangiitis

Answer 11

p-ANCA

Question 12

Wegener and MPA cause

Answer 12

pauci-immune crescentic GN

Question 13

Target in anti-GBM

Answer 13

NC1 domain of tpe IV collagen

Question 14

LM in anti-GBM

Answer 14

cellular crescents (macrophages, PMNs, lymphs, podocytes, fibrin) become fibrous crescents

Question 15

IF in anti-GBM

Answer 15

linear IgG of GBM

Question 16

Thrombotic microangiopathies involving kindey (5)

Answer 16

HUS, TTP, malignant HTN, anti-phospholipid syndrome, cyclosporin/tacrolimus toxicity

Question 17

Histo of HUS and TTP

Answer 17

fibrin thrombi in capillaries and small arteries, ischemic collapse of glomeruli, RBC fragments

Question 18

Mutation in Alports

Answer 18

type IV collagen
X-linked: C terminal of alpha 5 chain
(Others alpha 3 or alpha 4)

Question 19

EM in Alports

Answer 19

irregular contours of GBM

“basketweave”

Question 20

Lesion seen on LM in Alports

Answer 20

Interstitial foam cells

Question 21

Thin GBM dz clinical and EM

Answer 21

hematuria with normal renal function

GBM <200 nm

Question 22

Flattening of tubular epithelium with loss of brush borders with granular casts

Answer 22

ATN (ischemic or toxic)

Question 23

Interstitial inflammatory infiltrate (lymphs, PCs, Eos, granulomas

Answer 23

Drug-induced acute interstitial nephritis

Question 24

Acute renal allograft rejection

Answer 24

tubulitis, interstitial inflammation, endothelitis, transmural necrosis of arteries

Question 25

Chronic renal allograft rejection

Answer 25

intimal thickening of arteries, ischemic changes

Question 26

3 findings in cyclosporin/tacrolimus toxicity

Answer 26

1. tubular epithelial vacuolization 2. hyaline artiopathy 3. thrombotic microangiopathy

Question 27

Diseases usually presenting with nephrotic syndrome (4)

Answer 27

Minimal change, FSGS, Membranous, Diabetic,

Question 28

Disease usually presenting with nephritis syndrome (2)

Answer 28

Post-infectious, | Crescentic glomerulonephritis

Question 29

Renal dzs assd with Hep C

Answer 29

Membranoproliferative, | Cryoglobulinemia