Renal Ca

Question 1

Risk factors of rcc

Answer 1

Tobacco
Obesity
Hypertension
Esrd with acquired cystic ds
Hereditary

Question 2

Mc type of RCC

Answer 2

CLEAR CELL%75- prox tubule 
Papillary 15 prox tub
Chrome phobe
Oncocytoma 5 each from distal 
Collecting duct less than 1 %

Question 3

How many pt undergoing dialysis develop acquired cystic disease kidney

Answer 3

40-50%

5.8% of those cysts dvelop rcc mc papillary

Question 4

Which familial rcc aw clear cell histology

Answer 4

Vhl-3p ✅
Hereditary papillary rcc 7q
Hereditary leiomyomatosis rcc 1q
Birt hogg dube 17p11
Sdh ✅
TSC9q 16p

Question 5

C met gene asso with

Answer 5

Hprc

Question 6

Which rcc affects m=f with excellent prognosis

Answer 6

Chromophobe

Question 7

Rcc mc in women

Answer 7

Mucinous tubular

Question 8

Sundrome with uterine fibroids early pmset
Adtenal hyperplasia
Kidney cancer

Answer 8

Hlrcc

Question 9

.Immuno PET using antibody against carbonic

anhydrase IX is useful in which subtype of RCC

Answer 9

Clear cell and papillary

Question 10

Esrd which yr sceening start

Answer 10

3 yr

Question 11

Bap1 tumor aw

Answer 11

Clear cell

Question 12

Melanoma and hif1

Answer 12

MiTF

Question 13

Screening-Rcc

Answer 13

Vhl and hlrcc

From 16 yr

Question 14

HGF aw

Answer 14

Papillary type

Question 15

Xp RCC

Answer 15

Papillary

Question 16

Rcc in cowden

Answer 16

Papillary
Pten
Killin mutations

Question 17

How many ct enhancing lesions are benign-rcc

Answer 17

20%

Question 18

Plant cells seen in

Answer 18

Chromophobe
Positive hales colloid iron stain
CK7 esinophilic subtype

Question 19

Plant cell

Answer 19

Chromophobe

Positive hales colloid iron stain

Question 20

Hyper vascular tumors

Answer 20

Clear cell

Question 21

Multicentric rcc

Answer 21

Papillry

Question 22

Best prognosis

Answer 22

Papilary 1

Question 23

Mc paraneoplastic

Answer 23

Elevated esr

Question 24

Stauffers syndrome whats elevated

Answer 24

ALP

Question 25

Absolute ci for cytoreductive nephrectomy

Answer 25

Brain mets Poor performanxe status Relative- non clear cell

Question 26

Mskcc prognostic system

Answer 26

``` Low karnofsky High ldh Low hb High ca Time from dx to tt less than 1 yr ```

Question 27

Imdc

Answer 27

``` Low karnofsky Low hb High ca Time les than 1 yr High neutro High platelet ```

Question 28

Radical mephrectomy

Answer 28

Robson

Question 29

Partial nephrectomy normal percentage left behind in solitary

Answer 29

20-30%

Question 30

Prevalence of ln mets on rcc

Answer 30

6%

Question 31

Partial nephrectomy indication

Answer 31

``` Indication • Small unilateral tumors (Tia, selected Tib) • Tumor in • Uninephric state • Renal insufficiency • Familial tumor • Bilateral tumor Note- Tra-*tumor 4cm or less limited to kidney Tib > tumor >4cm but not >7cm limited to kidney Stage I > T1 NO MO Renal vein thrombus not a ci ```

Question 32

Local recurrence after prtial nephrectomy

Answer 32

3-5%

Question 33

Surveilance after thermal ablation rcc

Answer 33

Annual cxr 6 m mri 3 m ct

Question 34

• In Small incidentally diagnosed renal tumours what percentage of tumours will have zero radiographic growth in 36 months

Answer 34

30%

Question 35

Linear volumetric growth of radiologically localised small rcc

Answer 35

0.3cm per yr

Question 36

Surveillance size cut of

Answer 36

Solid tumors 2 cm Cystic 4 cm Familial 3 cm

Question 37

Highest response chemo in mets rcc

Answer 37

Lenvatenib

Question 38

Pref drug for clear cell

Answer 38

Axitinib + pembrolizumab • Cabozantinib + nivolumab • lenvatinib + pembrolizumab®

Question 39

Pref regime for nonclear cell

Answer 39

Cabozantinib | Sunitinib

Question 40

Maligannt features in ivu

Answer 40

Calcification within the mass •increased tissue densit • Irregular margins • Distortion of collecting system

Question 41

Hu less than 20 solid mass negative attenuation

Answer 41

Aml

Question 42

Rcc if contrast more than hu?

Answer 42

15

Question 43

Sestamini pet used in which rcc

Answer 43

Chromophobe

Question 44

Radical nephrect criteria

Answer 44

, RN is preferred if all of the following criteria are met: (1) high tumor complexity and PN would be challenging even in experienced hands; (2) no preexisting chronic kidney disease (CKD) or proteinuria; and (3) normal contralateral kidney and new baseline estimated glomerular filtration rate (eGFR) will likely de >45 mL/min/1.73 m2

Question 45

Ariser trial Everest trial Prosper trial Immotion trial

Answer 45

Girentuximab Everolimus Nivolumab Atezolilumab

Question 46

Carmena | Surtime trial

Answer 46

Targeted therapy sunitinib and cytoreductive nephrectomy

Question 47

Uiss

Answer 47

Tnm Performance Tr grade

Question 48

Mc tumor mets to kidney is from

Answer 48

Lung

Question 49

Chemo indicated in rcc

Answer 49

Chromophobe and medullary Carbo gemcit Paclicarbo

Question 50

Genetic screening indication in rcc

Answer 50

``` Dx les than or eq 46 yrs Bil or multifocal tr One or more first or second degree relative with rcc Histology - multifocal papillary Hlrcc Bhd Aml tsc Sdh ```

Question 51

Everolimus prophylaxis

Answer 51

Aml tsc more than 3 cm

Question 52

Tumor ablation highest for

Answer 52

Posterior lesions

Question 53

Tumor venous thrombus levels in rcc

Answer 53

``` 0- renal vein 1- ivc less than 2 cm above rv 2- more than 2 cm but below hep vein 3- to or above hep v but below diaphragm 4- above diaphragm ```

Question 54

Ln d done in rcc ?

Answer 54

Children or young adults

Question 55

Markers of rcc

Answer 55

Cc rcc- ca 9 | Aquaporin1 and perilipin 2