Renal Endocrinology Flashcards
(26 cards)
The small glycoprotein hormone that is essential to production of RBC is _________________________
Erythropoeitin (EPO)
What is EPO regulated by?
Amount of O2 delivered to the kidney
Hypoxia would lead to what in relation to EPO
Lead to an increased number of cells producing EPO
List 3 things that would stimulate EPO production
- hypoxia
- androgens
- alkalosis
- catecholamines
- adenosine
EPO production is decreased with what pathology?
CKD (leads to anemia)
List the 3 key hormones involved in the regulation of Ca and P
- PTH
- Calcitonin
- Vitamin D
Which hormone is released in response to low blood Ca?
PTH
Which hormone is released in response to high blood Ca?
Calcitonin
What generates Vitamin D3?
skin by sunlight or diet
1,25 hydroxycalciferol would be converted where?
In the kidney (tightly regulated)
How is Vitamin D3 transported?
Carrier proteins in the blood
T/F Dogs and cats can convert sunlight into Vit D3 efficiently
False
Vitamin D3 (calcitriol) increases or decreases the absorption of Ca/P from the kidney
Increases
The receptors for Vitamin D are in the cell or outside of the cell?
intracellular
Why is Vit D3 the most bioactive Vit D compound?
It has the highest binding affinity for receptors
What is the disease seen with vitamin D deficiency?
Rickets
Where is the majority of Ca reabsorbed in the nephron?
Proximal tubule
Where in the nephron Is Ca mostly regulated at?
Thick ascending LoH and DCT and CD
What stimulates the secretion of PTH?
Low Ca
PTH will increase Ca transport in the DCT/CD in what part of the cell?
Apical
What happens in the PCT in relation to Ca regulation?
Converted into the active form calcitriol
Calcitonin will __________ (increase/decrease) plasma Ca
decrease
Describe general movement of phosphate in the nephron
Majority absorbed by the proximal tubule
The uptake of phosphate is regulated by:
Apical transporters abundance
