Renal Glomerulonephritis Flashcards Preview

AB 2nd Year General > Renal Glomerulonephritis > Flashcards

Flashcards in Renal Glomerulonephritis Deck (41)
Loading flashcards...
1

what does non proliferative effect?

podocytes

2

what does podocyte damage cause in the urine?

protein

3

for nephrotic syndrome, what does the protein need to be over?

3.5

4

commonest in children?

minimal change

5

biopsy of minimal change?

podocyte foot process fusion on EM

6

treatment of minimal change?

steroids and cyclophosphamide

7

can minimal change result in renal failure?

no

8

commonest in adults?

focal segmented

9

what can cause focal segmented?

HIV
heroin use
obesity
reflux nephropathy

10

what does the biopsy in focal segmented show?

segmental glomerulosclerosis (progresses to global) on LM

11

presentation of focal segmented?

massive proteinuria - frothy urine
haematuria
HT
renal impairment

12

treatment of focal segmented?

steroids and cyclophosphamide

13

can you get renal failure form focal segmented?

50% go on to have RF

14

second commonest in adults?

membranous nephropathy

15

causes of membranous nephropathy?

hep B
CTD
Malignancy
gold/penicillin

16

biopsy of membranous nephropathy?

thickened basement membrane
'spike and dome appearance' on IF

17

treatment of membranous nephropathy?

steroids
alkylating agents
B cell monoclonal ABs
cyclophosphamide

18

can you get renal failure in membranous nephropathy?

yes, 1/3rd go on to get

19

features of nephrotic syndrome

hypoalbuminaemia
proteinuria >3.5
oedema
hypercholesterolaemia
prothrombogenic
normal/altered BP and GFR

20

what one causes macroscopic haematuria after a resp/GI infection?

IgA nephropathy

21

associated with IgA nephropathy?

Henoch Schonlein Purpura

22

biopsy of IgA nephropathy?

mesangial cell proliferation and expansion on LM
IgA deposits on IF

23

treatment of IgA nephropathy?

BP control and fish oil

24

can you get renal failure after IgA nephropathy?

yes, 1/3rd go on to

25

what cells does a proliferative process effect?

endothelial

26

what does endothelial cell damage cause?

haematuria

27

what does GBM damage cause?

blood

28

features of nephritic syndrome?

haematuria
acute renal failure
increased BP

29

what can occur weeks after a URTI or strep infection?

post strep glomerulonephritis

30

what strep usually causes post strep glomerulonephritis?

strep pyogenes