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AB 2nd Year General > Diabetes Drugs > Flashcards

Flashcards in Diabetes Drugs Deck (24)
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1

examples of sulphonylureas?

gliclazide
glipizide
glibenclamide

2

how to sulphonylureas work?

bind to SUR1, close K channel
increase insulin

3

what do sulphonylureas cause?

decrease HbA1c
prevent microvascular comps

4

side effects of sulphonylureas?

hypos
weight gain
GI upset
headche

5

when do you avoid sulphonylureas?

renal/hepatic failure

6

when are sulphonylureas first line?

if underweight

7

what are incretins? example?

GLP-1 receptor agonists
exanatide

8

what do incretins cause?

weight loss
decreased hepatic fat accumulation

9

side effects of incretins?

nausea
hypos
pancreatitis

10

examples of DPP-4 inhibitors?

sitagliptin

11

what do DPP-4 inhibitors cause?

no hypos
no affect on wt

12

example of biguanides?

metformin

13

what do biguanides cause?

decreased HbA1C
wt loss
prevents micro and macro vascular comps
minor BP decrease

14

are biguanides safe in pregnancy?

yes

15

side effects of biguanides?

GI upset
lactic acidosis
rash

16

when should biguanides be avoided?

renal or hepatic failure
(EGFR <60 reduce, <30 STOP)

17

examples of thiazolidinones?

pioglitazone

18

what do thiazolidinones cause?

decrease HbA1C
prevent macrovascular comps
fatty acid uptake and storage
decrease hepatic glucose output

19

side effects of thiazolidinones?

wt gain
fluid retention
hepatotoxic
increased risk of #

20

who should not use thiazolidinones?

over 65s
HF patients

21

examples of SGLT2 inhibitors?

dapagliflozin
canagliflozin

22

what do SGLT2 inhibitors cause?

calories and water loss

23

side effects of SGLT2 inhibitors?

thrush
UTIs
bp drop if works too quickly

24

pathway of T2DM treatment

metformin
+ DPP-4/pioglitazone/SU
metformin, DPP-4, SU OR metformin, pioglitazone, SU
insulin
metformin, SU, GLP-1