Renal Pathology Lecture 1 Flashcards
(12 cards)
1
Q
4 components of the kidney
A
Glomeruli
Tubules
Interstitium
Blood vessels
2
Q
What type of collagen makes up the GBM
A
Type IV (3 alpha chains make up a helix to form a monomer)
3
Q
What gives the GBM its negative charge
A
Heparin sulfate
4
Q
Visceral epithelial cells are also called
A
Podocytes
5
Q
2 slight diaphragm proteins?
A
Nephrin
Podocin
6
Q
Basics of glomerular filtration
A
- Large molecules are less permeable
- Negative charges are not as permeable
- Nearly complete exclusion of albumin in urine normally
- High permeability to H2O and lmw proteins
7
Q
Podocyte fusion is characteristic of
A
neph syndrome
8
Q
11% of adults are affected by
A
Chronic renal disease
9
Q
Glom. renal diseases are ususally
A
immune mediated
10
Q
Tubular/interstitial renal disease are usually
A
toxic or inflammatory reactions
11
Q
Increased BUN and creatinine =
A
Azotemia
12
Q
Pre renal causes of azotemia
A
usually hypoperfusion (hemorrhage, shock, dehydration, CHF)
