Renal X: CKD Flashcards

1
Q

______ diuretics should be avoided in CKD

A

Potassium-sparing

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2
Q

______ stimulates absorption of phosphorous and calcium from the small intestine.

A

Vitamin D

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3
Q

Acute treatment for hyperkalemia (5)

A

hemodialysis, calcium gluconate, insulin/glucose, albuterol, sodium bicarbonate

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4
Q

As GFR falls, Vitamin D levels _____.

A

decrease

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5
Q

Decreased Vitamin D _____ PTH.

A

increases

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6
Q

FGF-23 _____ Vitamin D production.

A

decreases

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7
Q

High levels of PTH cause ________.

A

osteitis fibrosa

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8
Q

In chronic kidney disease, urine concentration is generally ________.

A

fixed

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9
Q

In CKD, ammonia production is _______.

A

increased

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10
Q

In CKD, phosphorous is ________ and calcium is _______.

A

increased; decreased

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11
Q

In late stages of disease, potassium excretion is maintained by _______.

A

Fecal excretion

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12
Q

Major classes of immune suppresion in transplant

A

Calcineurin inhibitors, proliferation inhibitors, prednisone

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13
Q

Mechanisms of anemia in CKD (4)

A

Decreased EPO, blood loss, marrow fibrosis, shortened RBC lifespan

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14
Q

Most common cause of resistance to EPO therapy

A

iron deficiency

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15
Q

Release of ________ allows for excretion of phosphorous.

A

PTH

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16
Q

What drug classes are used to treat renal osteodystrophy?

A

Phosphate binders, Vitamin D compounds, Calcimimetics

17
Q

What drugs? Calcimimetics

A

Cinacalcet

18
Q

What drugs? Calcineurin inhibitors

A

Cyclosporine, tacrolimus

19
Q

What drugs? Phosphate binders

A

calcium acetate, sevelamer HCl, sevelamer bicarbonate

20
Q

What drugs? Proliferation inhibitors

A

Mycophenolate Mofetil, sirolimus, everolimus

21
Q

What drugs? Treatment of anemia in CKD

A

Epoetin, Darbepoetin

22
Q

What drugs? Vitamin D compounds

A

calcitriol

23
Q

What substances vasoconstrict afferent arterioles? (4)

A

AngII, norepinephrine, adenosine, NSAIDs

24
Q

What substances vasoconstrict efferent arterioles (2)

A

AngII, norepinephrine

25
Q

What substances vasodilate afferent arterioles? (4)

A

NO, prostaglandins, Dopamine, Caffeine

26
Q

What substances vasodilate efferent arterioles (2)

A

ACEIs, ARBs