Replication_Lecture4 - Manel Camps

Question 1

FtsZ

Answer 1

An important protein for cell division. Binds GTP, forms protofilaments, and interacts with other cell division proteins. Localizes at Z-Ring.

Question 2

SulA

Answer 2

Inhibits FtsZ polymerization by finding to FtsZ monomers. Unregulated in response to DNA damage via the SOS response.

Question 3

SOS Response Pathway

Answer 3

DNA Damage > RecA activity > Cleavage of LexA repressor > altered transcription (including SulA) due to derepression.

Question 4

ZapA

Answer 4

Promotes Z-Ring assembly. Interacts with FtsZ and enhances polymerization and polymer stability. Inhibits GTPase activity.

Question 5

MinC

Answer 5

Inhibitor of FtsZ localization. Activated by MinD binding.

Question 6

MinD

Answer 6

Activator of MinC activity. Localizes to poles in ATP-bound form.

Question 7

MinE

Answer 7

ATPase that pushes membrane/ATP bound MinD off membrane.

Question 8

Nucleoid Occlusion (Noc)

Answer 8

DNA binding proteins that inhibit FtsZ ring formation.

Question 9

SlmA

Answer 9

A nucleoid occlusion protein that inhibits FtsZ ring formation.