Flashcards in repro pharm Deck (30)
what syndrome is because there the neural crest cells don't migrate far enough so the GnRH doesn't get to the portal system?
GnRH level agonists used for
Progressive Precocious puberty
GnRH activity modulated by what part?
glycine residue in the middle, cleaved here
GnRHbinds to receptor and activates what cascade?
Goserelin Triptorelin.....other relins
GnRH with longer half life act eventually as?
antagonist bc they desensitize the receptors
GnRH agonists/ants used in?
Progressive precocious puberty
Trans youth prepubertal
in women: symptoms of menopause, ovarian cysts, osteoporis
in men: hot flushs, sweats, edema, gynecomastia, osteoporosis
FSH and LH act through the
FSH agonists (mainly)
menotropins (both FSH and LH high in menopausal women, isolated from them)
Follitropins alpha and beta
LH and FSH agonists used for
ovulation induction and male infertility
toxicities of LH and FSH therapies
headaches, depression edema, precocious puberty
hot flushes/menopausal symptoms
estrogen main type?
main progestagen type
Natural estrogen receptor agonists
estradiol, estrone, estriol
synthetic receptor agonists
steroidal ethinyl E2, mostronol, quinestrol
Estrogen agonists used for
Tamoxifen is antagonist of estrogen but agonist in ______ which would cause____
partial agonist in the endometrium and bone causing endometrial hyperplasia
Clomiphene antagonist of the _______ partial agonist of the _____
hypothalamus/pit causing infertility or ovulatory disorder
p/agonist in the ovary
Estrogen receptor antagonist
ER+ metastatic breast cancer treated with
Raloxifene antagonist in the ________ agonist in the ____
antag of the uterus and breast
agonist of the bone
Estrogen contraindicated in?
Progestins receptor binding used for emergency contraceptive
aromatase inhibitors competitive
anastrazole and letrozole