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Flashcards in repro pharm Deck (30)
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1

what syndrome is because there the neural crest cells don't migrate far enough so the GnRH doesn't get to the portal system?

Kallman syndrom
(+anosmia)

2

GnRH level agonists used for

Progressive Precocious puberty

3

GnRH activity modulated by what part?

glycine residue in the middle, cleaved here

4

GnRHbinds to receptor and activates what cascade?

Ca, PKC

5

GnRH agonists

Goserelin Triptorelin.....other relins

6

GnRH with longer half life act eventually as?

antagonist bc they desensitize the receptors

7

GnRH antagonists

-relix

8

GnRH agonists/ants used in?

Progressive precocious puberty

Prostate cancer

Endometriosis

Assisted repro

Uterine Leiomyomas

Trans youth prepubertal

9

GnRH toxicity

in women: symptoms of menopause, ovarian cysts, osteoporis

in men: hot flushs, sweats, edema, gynecomastia, osteoporosis

10

FSH and LH act through the

GCPR-->PKA cascade

11

FSH agonists (mainly)

menotropins (both FSH and LH high in menopausal women, isolated from them)

Follitropins alpha and beta

Urofollitropin

12

LH agonists

Lutropin

13

LH and FSH agonists used for

ovulation induction and male infertility

14

toxicities of LH and FSH therapies

multiple pregnancies

headaches, depression edema, precocious puberty

hot flushes/menopausal symptoms

15

estrogen main type?

estradiol E2

16

main progestagen type

P4

17

Estrogen types

Receptor antagonists

SERMs

Receptor Agonists

18

Natural estrogen receptor agonists

estradiol, estrone, estriol

19

synthetic receptor agonists

steroidal ethinyl E2, mostronol, quinestrol

20

Estrogen agonists used for

HRT

Oral contraceptives

Osteoporosis

Infertility

Dysmenorrhea

Hypogonadism

21

3 SERMs

Tamoixfen

Clomiphene

Raloxifene

22

Tamoxifen is antagonist of estrogen but agonist in ______ which would cause____

partial agonist in the endometrium and bone causing endometrial hyperplasia

23

Clomiphene antagonist of the _______ partial agonist of the _____

hypothalamus/pit causing infertility or ovulatory disorder

p/agonist in the ovary

24

Estrogen receptor antagonist

Fulvestrant

25

ER+ metastatic breast cancer treated with

fulvestrant

26

Raloxifene antagonist in the ________ agonist in the ____

antag of the uterus and breast

agonist of the bone

27

Estrogen contraindicated in?

breast/endometrial cancer

clotting disorders

28

Progestins receptor binding used for emergency contraceptive

mifepristone

29

aromatase inhibitors competitive

anastrazole and letrozole

30

aromatase inhibitors irreversible

examestane formestane