repro pharm

Question 1

what syndrome is because there the neural crest cells don’t migrate far enough so the GnRH doesn’t get to the portal system?

Answer 1

Kallman syndrom

+anosmia

Question 2

GnRH level agonists used for

Answer 2

Progressive Precocious puberty

Question 3

GnRH activity modulated by what part?

Answer 3

glycine residue in the middle, cleaved here

Question 4

GnRHbinds to receptor and activates what cascade?

Answer 4

Ca, PKC

Question 5

GnRH agonists

Answer 5

Goserelin Triptorelin…..other relins

Question 6

GnRH with longer half life act eventually as?

Answer 6

antagonist bc they desensitize the receptors

Question 7

GnRH antagonists

Answer 7

-relix

Question 8

GnRH agonists/ants used in?

Answer 8

Progressive precocious puberty

Prostate cancer

Endometriosis

Assisted repro

Uterine Leiomyomas

Trans youth prepubertal

Question 9

GnRH toxicity

Answer 9

in women: symptoms of menopause, ovarian cysts, osteoporis

in men: hot flushs, sweats, edema, gynecomastia, osteoporosis

Question 10

FSH and LH act through the

Answer 10

GCPR–>PKA cascade

Question 11

FSH agonists (mainly)

Answer 11

menotropins (both FSH and LH high in menopausal women, isolated from them)

Follitropins alpha and beta

Urofollitropin

Question 12

LH agonists

Answer 12

Lutropin

Question 13

LH and FSH agonists used for

Answer 13

ovulation induction and male infertility

Question 14

toxicities of LH and FSH therapies

Answer 14

multiple pregnancies

headaches, depression edema, precocious puberty

hot flushes/menopausal symptoms

Question 15

estrogen main type?

Answer 15

estradiol E2

Question 16

main progestagen type

Answer 16

P4

Question 17

Estrogen types

Answer 17

Receptor antagonists

SERMs

Receptor Agonists

Question 18

Natural estrogen receptor agonists

Answer 18

estradiol, estrone, estriol

Question 19

synthetic receptor agonists

Answer 19

steroidal ethinyl E2, mostronol, quinestrol

Question 20

Estrogen agonists used for

Answer 20

HRT

Oral contraceptives

Osteoporosis

Infertility

Dysmenorrhea

Hypogonadism

Question 21

3 SERMs

Answer 21

Tamoixfen

Clomiphene

Raloxifene

Question 22

Tamoxifen is antagonist of estrogen but agonist in ______ which would cause____

Answer 22

partial agonist in the endometrium and bone causing endometrial hyperplasia

Question 23

Clomiphene antagonist of the _______ partial agonist of the _____

Answer 23

hypothalamus/pit causing infertility or ovulatory disorder

p/agonist in the ovary

Question 24

Estrogen receptor antagonist

Answer 24

Fulvestrant

Question 25

ER+ metastatic breast cancer treated with

Answer 25

fulvestrant

Question 26

Raloxifene antagonist in the ________ agonist in the ____

Answer 26

antag of the uterus and breast agonist of the bone

Question 27

Estrogen contraindicated in?

Answer 27

breast/endometrial cancer clotting disorders

Question 28

Progestins receptor binding used for emergency contraceptive

Answer 28

mifepristone

Question 29

aromatase inhibitors competitive

Answer 29

anastrazole and letrozole

Question 30

aromatase inhibitors irreversible

Answer 30

examestane formestane