resisting resistance Flashcards
(12 cards)
most effective techniques for resistance mangement
manipulate dominance, manipulate % + mut supply, transgenic tool
pros of GM
increased food, security, economic gains, no need for re-emergence spraying, reduced C footprint, reduce use of them pesticides
cons of GM
trngenes may hybridise, increase toxicity to living orgs, reduces biodiversity by reducing weeds forming supersedes
high dose
causes 99.99% mortality, causes recessive resistance
high dose refuge strat
way to keep frequencies low to control recessive resistance
pros of biotech crops
cost effective, biological pesticides, pmroe stable dose, can combine multiple, saving, reduced C
assumptions for high dose refuge strategies
random mating, random oviposition, low % of resistance alleles, doses must be high
monotherpay
using a single drug
combo therapy
using multiple drugs at the same time
principles of combo therapy
evolution of spontaneous must are expected to be beneficial, combos often drive down pop sizes
what increase drug resistance of genes
ppl not taking for full term, where ppl come from receive 1 drug vs combo therapies, pharmoacogenetics