resp drugs Flashcards
(34 cards)
SABA EX
salbutamol
SABA IN
asthma
COPD
SABA MA
B2 adrenoreceptor agonists
(bronchodilation + decrease in mucus)
SABA CC
arrhythmias
CVD
diabetes
HTN
hyperthyroidism
hypokalaemia
QT prolongation
SABA SA
tremor
can affect heart rhythm
LABA EX
beclomethasone
LABA IN
nocturnal asthma
COPD
LABA MA
B2 adrenoreceptor agonist - delayed onset
LABA CC
arrhythmias
CVD
diabetes
HTN
hyperthyroidism
hypokalaemia
QT prolongation
LABA SA
B2 down regulation + tachyphylaxis (tolerance) in long-term use
can worsen asthma when used alone
ICS IN
asthma
COPD
ICS MA
synthetic glucocorticoids, switches on genes
(anti-inflammatory, no bronchodilator effect)
ICS SA
dysphonia + oropharyngeal candidiasis
pneumonia in COPD
montelukast IN
+ in asthma
montelukast MA
cysteinyl leukotriene receptor antagonist
prevent CysLTs from causing bronchoconstriction, decrease mucus secretion + oedema
montelukast SA
generally well tolerated!
headache
GI upset
theophylline IN
+ in asthma
(IV = acute)
theophylline MA
xanthine
(maybe) inhibit phosphodiesterases -> inactivate cAMP + cGMP
(inhibit mast cells, increase mucus clearance, increase diaphragm contraction, decrease fatigue)
theophylline CC
interactions w/ CYP450s (specific antibiotics)
theophylline SA
v narrow therapeutic window!
supra = dysrhythmias, seizures, hypotension
therapeutic = N+V, headache, abdominal discomfort
chromones IN
+ in severe allergic asthma
chromones MA
mast cell stabilizer
omalizumab IN
+ in asthma
omalizumab MA
anti IgE
