Respiration - ventiliation and gas exchange Flashcards

(53 cards)

1
Q

What is hypervenitlation?

A

excessive ventiatioic atop of metabolic demand

so reduced pressure CO2 and alkalosis

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2
Q

Label this graph of lung volume changes

A
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3
Q

what is tidal volume?

A

normal air in and out

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4
Q

What is inspiratory and expiratory reserve volume?

A

in - extra amount you could get

ex - the air left in your lungs, to hold lung strucutre

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5
Q

What is vital capacity and total lung capacity?

A
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6
Q

What is functional residual capactiy?

A

everything below our default position

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7
Q

what is inspiratory capacity?

A

amount of air from default position i.e relaxed state of our lungs

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8
Q

How do you calculate minute ventilation (L/minute)?

gas entering and leabing lungs

A

tidal volume x breathing frequenecy

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9
Q

What is alveolar ventialiation?

A

the air entering and leaving Leaving alveoli

(tidal volume - dead space) x breathing freq

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10
Q

factors affect lung volumes and capaicty

A

body size - e.g overweight doesn’t mean have bigger lungs mainly height

sex - gentically men larger lung volume and total capacity

disease - break down tissues, can go up and down

age

fitness- larger volume

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11
Q

what is conducting zone?

A

small volume, anatomical dead space

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12
Q

What is non-perfused parenchyma?

A

alveoli without blood, no gas exhcange

aveolar dead space

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13
Q

What is the physiological dead space made of?

A

non-perfused parenchyma

and conducting zone

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14
Q

what is respiration zone?

A

gas exhange

alveolar ventilation

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15
Q

What can increase dead space?

A

anaethetic circuit snorkerlling

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16
Q

What can decrease dead space?

A

tracheostomy - take out trachea

cricothyrocotomy

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17
Q

What tendency do lungs and chest wall ahve?

A

chest wall - spring out

lung - recoid inwards

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18
Q

What is the functional residnaul capacity?

A

eqilirum at end- tidal expiration

between chest recoil and lung recoil

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19
Q

How do you change this balance?

A

inspiratioru muscles combing with chest recoil, outwarsds

expiratory combine with lung to inwards

distort eqlibirum

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20
Q

What is lung surroned by?

A

visceral pleural membrane

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21
Q

What is the inner surface of chest wall covered by?

A

parietal pleural membrane

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22
Q

What is the pleural cavity?

What is improant about it?

A

fixed volume and contains protien rich pleural fluid

23
Q

What could intrapleural bleeding and pneumothorax do?

A

bleed- prevent ability to breathe

perforated wall - puncture causes air to be sucked in and lung collapse

24
Q

What are 2 ways of air perssure flow? i.e how do we get air into lungs

A

from HIGH to LOW

-ve perssure: alveoli p lower than atm, so sucks in air

+ve: incrase pressure in atm higher than alveoli causing air in

25
What pressure gradient is normal?
usaully negative
26
Which one is abnormal?
Positive - mechnaical ventiliator, CPR, fihgter pilots - situations lung muscles aren't able to produce -ve pressure
27
What is transmural pressure? 3x one is most importnat for us
pressure between 2 areas
28
How do you calculate PRS? transrespiratory system pressure
P alveoli - P atm when -ve air into lung, INSPIRATION when +ve expiration, EXPIRATION
29
What muscles cause inspiration?
diaphram - pulling force one direction MAIN ONE other respiratiory muscles - upwards and outwards
30
What is dalton law?
gas mixture= sum of partial pressure
31
What is ficks law?
things that increase diffusion i.e gradient, surface area, diffusion capacity of gas and thickness of exhcange suraface
32
What is henry law?
how easily gas is to dissolve, amount of gas that dissolves in liquid, is proportional to partial pressure of gas in eqil with that lqiuid
33
What is Boyle law?
volume is inversly proportional to pressure of gas
34
What is charles law?
volume of gas proportional to temperaute
35
Disucess how air changes in pressure for O2 CO2 and H20 as goes in airways?
conducting - saturate air to protect, hydrates respiration - oxygen diluated as air already in airways, same reason for C02
36
What is important about afinity of oxygen to Hb?
more oxygen, easier to bind, as conformation changes and there is space in middle of 2,3-DPG that faccilates unloading COOPERATIVE
37
What a protien called when it changes shape when it is bound or unbound?
ALLOSTERIC behaviour
38
What is important factor to take into account when thinking about oxygen saturation?
HOW MUCh HAEMAGLOBIN IS THERE
39
How does oxygen dissocation shift right?
allows easily release of O2 at tissues
40
How does oxygen dissocation shift left?
41
How does oxygen dissocation DOWNWARD shift?
anemia, impaired oxygen
42
What affect does CO have on oxygen dissociation curve?
DOWNWARD AND LEFT decreased capcaity but increased affintity (so O2 help on harder) and exercsie abiltiy is decrease
43
What effect does featal haemaglobin have?
greater affinity for oxygen than adult, extract oxygen from mothers
44
What effect does myoglonin have oxygen dissoation curve?
in muscles, local storage so high affinity
45
HOW DO you read oxygen dissociation curve and changes? SO forget partial pressure i.e X axis, that cant be changed it shows where place is i.e high pressure of 02 is in pulmonary where also has high saturation shift left - means at each level more affinitty and amount of 02 shift right - means less afinity, easier to ofload dwon shift- less variability between puloomnary and veins
46
How does C02 get loaded onto blood from cells?
47
Where does most of C02 go tho
48
What happens to carbonic acid produced by C02?
49
Can C02 also bind to haemo?
Yes
50
What changes in blood after transport of C02?
most important one pH and C02 influx is different to 02 DUE TO WATER
51
How long are RBC in trasnit time for gas exchange? what different for C02 than 02?
CO2 faster exchange than 02
52
How overall is C02 transported
most of it Enters RBC converted to carbonic acid SO MOST is bicarbonate in the blood and also bind to amine group of haemaglobin and haemaglobin buffers the H+
53
Why is C02 changes in blood different to amount of change in 02?
Because have H20 as a metabolic waste