respiratory therapy pt 2

Question 1

fluticasone moa

Answer 1

• Acts through classic steroid pathway inhibiting arachidonic acid-based eicosanoid production
• Steroidal Anti-Inflammatory

Question 2

fluticasone adverse effects

Answer 2

ADVERSE EFFECTS
Common: headache, cough, pyrexia, epistaxis, nasopharyngitis
SEVERE ADVERSE EFFECTS
Hormonal: adrenal suppression, hypercorticism, pediatric growth suppression
Nasal: nasal/oral candidiasis, nasal ulcer or septal perforation
Ocular: cataracts, glaucoma, elevated IOP

Question 3

salmeterol moa

Answer 3

Mechanism of Action
A chemical analog of Albuterol having a lipophilic side chain that enhances duration of action; like Albuterol, this β2 Agonist produces relaxation of airway smooth muscle
CLINICAL PHARMACOLOGY
Βronchodilator

Question 4

SALMETEROL
ADVERSE EFFECTS
SEVERE ADVERSE EFFECTS

Answer 4

SALMETEROL
ADVERSE EFFECTS
Common: headache, nasal congestion, rhinitis, bronchitis, urticaria, tachycardia
SEVERE ADVERSE EFFECTS
Hypersensitivity: anaphylaxis, angioedema
Respiratory: bronchospasm (paradoxical), asthma exacerbation/death
CV: arrhythmia, HTN

Question 5

Advair diskus indication

Answer 5

INDICATION
Asthma / COPD Maintenance
DOSING [100/50, 250/50, 500/50 μg]
1 puff bid

Question 6

ADVAIR DISKUS

DRUG INTERACTIONS

Answer 6

ADVAIR DISKUS
DRUG INTERACTIONS
Β-Blockers (Additive)
Cyclosporine, Azole antifungals (Impaired Metabolism)
Macrolides, Amphotericins, CAIs, Steroids (Hypokalemia)
Macrolides, Sympathomimetics (QT Prolongation)

Question 7

MOMETASONE

INDICATION

Answer 7

MOMETASONE
INDICATION
Allergic Rhinitis, Nasal Polyp Therapy
DOSING [50 μg/spray]
2 sprays qd-bid

Question 8

MOMETASONE
CLINICAL PHARMACOLOGY
Mechanism of Action

Answer 8

MOMETASONE
CLINICAL PHARMACOLOGY
Corticosteroid Nasal Spray
Mechanism of Action
Inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects

Question 9

MOMETASONE

ADVERSE EFFECTS

Answer 9

MOMETASONE
ADVERSE EFFECTS
Common: Headache, viral infection, epistaxis, conjunctivitis
NOTABLE ADVERSE EFFECTS
Sinus: Septal perforation, ulcer, candidiasis
Ocular: Elevated IOP, glaucoma

Question 10

MOMETASONE

DRUG INTERACTIONS

Answer 10

MOMETASONE
DRUG INTERACTIONS
NONE

Question 11

MOMETASONE

CONTRAINDICATIONS/CAUTIONS

Answer 11

MOMETASONE
CONTRAINDICATIONS/CAUTIONS
Nasal septal ulcer, recurrent epistaxis
TB infection
Ocular HSV infection, glaucoma, cataracts, vision changes

Question 12

Montelukast [Singulair®]
Albuterol [ProAir HFA®]
Fluticasone/Salmeterol [Advair Diskus®]
Mometasone [Nasonex®]

Answer 12

respiratory therapies

Question 13

-sone

Answer 13

respiratory drugs

Question 14

inhaled steroids are the first choice in what types of pt?

Answer 14

pts with persistent/severe asthma (routinely)

Question 15

90% of asthma therapy is what

Answer 15

swallowed

90% swallowed –> absorption in GI –> first pass in liver–> systemic side effect

10% of it actually reaches the lungs

Question 16

mouth rinsing is responsible for what?

Answer 16

loss of asthma drug

Question 17

creates unusual taste sensation

Answer 17

steroid in asthma therapy

Question 18

immunosuppressant property of steroid when inhaled can cause what?

Answer 18

potential to dev of microbial growth in oral cavity (gingivitis)

Question 19

what drug creates unusual taste sensation

Answer 19

steroid in asthma therapy

Question 20

immunosuppressant property of steroid when inhaled can cause what?

Answer 20

potential to dev of microbial growth in oral cavity (gingivitis)

Question 21

steroids inhibit what?

Answer 21

healing

Question 22

analog of albuterol

Answer 22

salmeterol

*lipophilic side chain

Question 23

FLUTICASONE
CLINICAL PHARMACOLOGY
Steroidal Anti-Inflammatory
Mechanism of Action
Acts through classic steroid pathway inhibiting arachidonic acid-based eicosanoid production

Answer 23

FLUTICASONE

CLINICAL PHARMACOLOGY

Question 24

FLUTICASONE
ADVERSE EFFECTS
Common: headache, cough, pyrexia, epistaxis, nasopharyngitis
SEVERE ADVERSE EFFECTS
Hormonal: adrenal suppression, hypercorticism, pediatric growth suppression
Nasal: nasal/oral candidiasis, nasal ulcer or septal perforation
Ocular: cataracts, glaucoma, elevated IOP

Answer 24

FLUTICASONE

ADVERSE EFFECTS

Question 25

``` SALMETEROL CLINICAL PHARMACOLOGY Βronchodilator Mechanism of Action A chemical analog of Albuterol having a lipophilic side chain that enhances duration of action; like Albuterol, this β2 Agonist produces relaxation of airway smooth muscle ```

Answer 25

SALMETEROL | CLINICAL PHARMACOLOGY

Question 26

``` SALMETEROL CLINICAL PHARMACOLOGY Βronchodilator Mechanism of Action A chemical analog of Albuterol having a lipophilic side chain that enhances duration of action; like Albuterol, this β2 Agonist produces relaxation of airway smooth muscle ```

Answer 26

SALMETEROL | CLINICAL PHARMACOLOGY

Question 27

SALMETEROL ADVERSE EFFECTS Common: headache, nasal congestion, rhinitis, bronchitis, urticaria, tachycardia SEVERE ADVERSE EFFECTS Hypersensitivity: anaphylaxis, angioedema Respiratory: bronchospasm (paradoxical), asthma exacerbation/death CV: arrhythmia, HTN

Answer 27

SALMETEROL | ADVERSE EFFECTS

Question 28

``` ADVAIR DISKUS INDICATION Asthma / COPD Maintenance DOSING [100/50, 250/50, 500/50 μg] 1 puff bid ```

Answer 28

ADVAIR DISKUS | INDICATION

Question 29

ADVAIR DISKUS DRUG INTERACTIONS Β-Blockers (Additive) Cyclosporine, Azole antifungals (Impaired Metabolism) Macrolides, Amphotericins, CAIs, Steroids (Hypokalemia) Macrolides, Sympathomimetics (QT Prolongation)

Answer 29

ADVAIR DISKUS | DRUG INTERACTIONS

Question 30

``` MOMETASONE INDICATION Allergic Rhinitis, Nasal Polyp Therapy DOSING [50 μg/spray] 2 sprays qd-bid ```

Answer 30

MOMETASONE | INDICATION