Flashcards in Restrictive Lung Diseases Deck (40)
A synonym for intrinsic restrictive lung disease is?
How is restrictive lung disease defined?
less than 80% (predicted) TLC (problems inflating the lungs) via a PFT
How is obstructive lung disease defined?
FEV1/FCV less than 70%
What are the most and least common cells in the lungs?
What is a normal CD4/CD8 ratio in the lungs?
What is sarcoidosis?
multisystem disorder of unidentified etiology characterized by non-caveating granulomas
What patient population is common for sarcoidosis?
young AA female adults (20-40 yo)
What happens to the size of alveoli in obstructive disease?
increases. EXPANDED lung disease
What happens to the size of conducting airways in restrictive disease?
decreases (or may not change) BUT expiratory velocity is increased
T or F. Lung volumes DECREASE in restrictive lung disease
T. Elastic recoil is increased
What is Type I restrictive disease?
disease involves lung (intrinsic)- ILD and lung resection
What is Type II restrictive disease?
disease involves pleura chest wall, muscles, ribs, etc. (extrinsic) and neuromuscular disorders
Interstitial lung disease (ILD) predominantly involve what part of the lung?
connective tissue of the alveolar wall (in between the epithelium and endothelium)
How would a person with restrictive lung disease breath?
short, small breaths (panting) because its too hard to inflate the lungs
What cases the hypoxemia of ILD (interstitial lung disease)?
V/Q mismatch (NOT diffusion defect because there is plenty of reserve length available)
What are some granulomatous causes of ILD?
What are some Non-granulomatous causes of ILD?
-asbestos, coal, silica
-Idiopathic Interstitial Pneumonia
-ILD with connective tissue disease
What are some drug causes of ILD (non-granulomatous)?
Bleomycin, amiodarone, nitrofurantoin
What are some types of ILD with connective tissue disease?
-Mixed CT disease
Symptoms of ILD?
-non-specific chest pain
-fatigue, weight loss
Signs of of ILD?
Why is digital clubbing seen in ILD?
fibrosis also occurs in the nail bed
T or F. Expiratory airflow is normal in ILD
T. TLC and VC are reduced though
Most of the diagnosis of ILD can be made by what?
high-resolution CT scan
What radiological feature is characteristic of early-stage ILD?
ground glass appearance (can be reversed)
What radiological feature is characteristic of mid-stage ILD?
reticulations and nodulations (most common)
What radiological feature is characteristic of late-stage ILD?
How is ILD diagnosed?
-Extensive history (genetics, occupation, meds, etc.)
-H&P (velcro crackles)
-BAL or lung biopsy
What is a bronchoalveolar lavage (BAL)?
Using a scope to sample alveolar cell populations