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Flashcards in Reticular Formation Deck (35):
1

What is the reticular formation?

Continuous network of nerve cells and fibers that extend through the neuroaxis from the SC to the cerebral cortex
- Acts like a fish net that catches collaterals from every ascending or descending system

2

What are the 7 general functions of the reticular formation?

- Control of skeletal muscle
- Control of somatic/ visceral sensation
- Cortical activation
- Control of ANS
- Control of Endocrine Nervous System with Hypothalamus
- Sleep

3

What are the 3 portions of the non-cerebellar reticular formation?

- Median longitudinal column
- Medial longitudinal column
- Lateral longitudinal column

4

What nuclei are found in the median longitudinal columns?

Raphe nuclei

5

What is the function of the median longtudinal column?

Pain/ motor modulation

6

What is the size of the median longitudinal column?

Intermediate size

7

What is the function of the medial longitudinal column?

Efferent system

8

What is the size of the medial longitudinal column?

Large (gigantocellular)

9

What is the size of the lateral column?

Small (parvocellular)

10

What is the function of the lateral longitudinal column?

Afferent system

11

What are the 3 pre-cerebellar longitudinal columns?

- Pontine reticulotegmental
- Paramedian reticular
- Lateral reticular

12

What is the function of serotonin?

- Mood (happiness, well being)
- Pain modulation
- Aggression
- Memory processing
- Sleep
- Cognition
- Food intake

13

Is serotonin a neurotransmitter?

No

14

Where is serotonin found in the reticular formation?

- Median area of reticular formation
- Dorsal and median raphe nuclei

15

What are the 5 functions of dopamine?

- Reward/ motivation
- Pleasure/ euphoria
- Motor funciton/ fine tuning
- Compulsion
- Preservation

16

In what 2 areas is dopamine found?

- Substantia nigra
- Ventral tegmental area

17

What is the function of the substantia nigra?

Facillitate voluntary movement

18

What is the function of the ventral tegmental area?

Reward systems
- Reinforces adaptive behaviors

19

Where is norepinephrine found in the reticular formation?

- LOCUS COERULEUS
- Pontine and medullary groups

20

What is the function of norepinephrine?

Regulates:
- Attention
- Arousal
- Sleep wake cycles
- Learning
- Memory
- Anxiety
- Pain
- Mood
- Brain metabolism

21

What type of stimuli activates norepinephrine?

Unexpected, non-painful sensory stimuli

22

What may result from an excess of norepinephrine?

Anxiety

23

What may result from a deficiency of norepinephrine?

Depression

24

What are the 3 major contributers to a balanced mood from the 3 neurochemicals involved in the reticular formation?

Dopamine: Alterness
Norepinephrine: Concentration
Serotonin: Satisfaction

25

What results from a combination of dopamine and serotonin?

Appetite

26

What results from a combination of dopamine and norepinephrine?

Attention

27

What results from a combination of serotonin and norepinephrine?

Intuition

28

What are the 2 types of ACh receptors?

Iontotrophic/ Nicotinic
Metabotropic/ Muscarinic

29

What 2 nuclei groups make up the basal forebrain complex?

- Medial septal nuclei
- Basal nuclei of Meynert

30

What does the basal forebrain complex supply?

The neocortex

31

What nuclei are found within the pontomesencephalotegmental complex?

Pedunculopontine nuclei

32

What do the pedunclopontine nuclei act on?

The dorsal thalamus (sets the threshold)

33

What is the role of ACh in the reticular formation?

- Regulation of excitability of sensory relay neurons and ARAS (acts as gatekeeper)
- Maintain attention
- Promotes REM sleep

34

What is the function of histamine in the reticular formation?

- Arousal
- Anxiety
- Activation of sympathetic nervous system
- Stress related release of hormones from pituitary
- Stress related release of central aminergic neurotransmitters
- Antinociception
- Water retention
- Supression of eating

35

What is the MAIN role of histamine in the reticular formation?

Controls the 3 other neurochemicals