Review #1

Question 1

Most common cause of non-immune fetal hydrops

Answer 1

Monosomy X

Question 2

Ultrasound features of Turner Syndrome

Answer 2

Coarctation of the aorta, short long bones, cystic hygroma

Question 3

Risk of pregnancy for someone with Turner Syndrome

Answer 3

Aortic dissection

Question 4

Cancers associated with BRCA

Answer 4

Prostate (BRCA1), pancreatic, melanoma (BRCA2), endometrial, gastric, biliary, colorectal

Question 5

Peutz-Jeghers gene

Answer 5

STK11

Question 6

Peutz-Jeghers cancers

Answer 6

Colon and rectal, pancreatic, stomach, small intestine

Question 7

Li-Fraumeni gene

Answer 7

TP53

Question 8

Li-Fraumeni cancers

Answer 8

Sarcoma, brain, leukemia, adenocortical

Question 9

Cowden gene

Answer 9

PTEN

Question 10

Cowden cancers

Answer 10

Endometrial, thyroid

Question 11

Hereditary nonpolyposis colorectal cancer genes

Answer 11

MLH1, MSH1, MSH6, PMS2

Question 12

HNPCC cancers

Answer 12

Colon, endometrial, gastric

Question 13

CHEK2 cancers

Answer 13

Colorectal, prostate, male breast, thyroid, kidney

Question 14

PALB2 cancers

Answer 14

Pancreatic, prostate

Question 15

ATM cancers

Answer 15

Leukemias and lymphomas

Question 16

Oligohydramnios

Answer 16

AFI < 5 cm, MVP < 2 cm

Question 17

Polyhydramnios

Answer 17

AFI > 24 cm, MVP > 8 cm

Question 18

AFI that warrants amnioreduction

Answer 18

> 35 cm

Question 19

Indication for antibiotics in HSG

Answer 19

Hydrosalpinx

Question 20

Risk of heterotopic pregnancy in IVF

Answer 20

1/100

Question 21

Angelman vs Prader-Willi genetics

Answer 21

Imprinting
Angelman - maternal
Prader-Willi - paternal

Question 22

Treatment for Group A strep

Answer 22

Penicillin G and clindamycin

Question 23

Antibiotics for fourth degree laceration?

Answer 23

No

Question 24

History indicated cerclage indication

Answer 24

One or more second trimester loss without labor or abruption

Question 25

History indicated cerclage timing

Answer 25

12-14 wga

Question 26

Ultrasound indicated cerclage indications

Answer 26

Singleton, history of preterm birth, CL <25 mm

Question 27

Ultrasound indicated cerclage timing

Answer 27

16-23 wga

Question 28

Physical exam indicated cerclage indications

Answer 28

Dilated cervix at 16-23 wga

Question 29

Primary syphilis symptoms

Answer 29

Painless chancre that develops about 21 days after infection and resolves 3-6 weeks later

Question 30

Secondary syphilis symptoms

Answer 30

2-10 weeks after chancre, adenopathy, constitutional symptoms, doffuse papular rash involving palms and soles, condyloma lata in moist folds

Question 31

Tertiary syphilis symptoms

Answer 31

Aortitis, neurosyphilis, gummas

Question 32

Early syphilis treatment

Answer 32

Penicillin G 2.4 million units IM once

Question 33

Late syphilis treatment

Answer 33

Penicillin G 2.4 million units IM weekly for 3 weeks

Question 34

Couvaire uterus

Answer 34

Caused by blood flow into myometrium during severe placental abruption

Question 35

Tumor marker associated with granulosa cell tumor

Answer 35

Inhibin

Question 36

Muscles potentially torn in second degree laceration

Answer 36

Pubococcygeus, bulbocavernosus, transverse perineal

Question 37

Chromosomes of BRCA 1, 2

Answer 37

17 and 13

Question 38

Stage egg is frozen for social cryopreservation

Answer 38

Mature oocyte: haploid cell with one polar body

Question 39

Treatment for prolactinoma

Answer 39

Dopamine agonist: cabergoline (less side effects) or bromocriptine

Question 40

Single agent chemo for nonmetastatic GTN

Answer 40

Methotrexate or actinomycin D

Question 41

Contraindication to Elagolix

Answer 41

Pregnancy, elevated LFTs

Question 42

Isolated ultrasound finding that confers greatest risk for trisomy 21

Answer 42

Thickened NT

Question 43

What type of gene is HER2?

Answer 43

Oncogene, encodes erbB2 tyrosine kinase, a constituively active protein that amplifies cell replication

Question 44

Mechanism of trastuzumab

Answer 44

Monoclonal antibody to inactivate HER2/neu receptor tyrosine kinase

Question 45

Inheritance pattern of BRCA

Answer 45

Autosomal dominant

Question 46

HPV, type of virus

Answer 46

Double stranded DNA

Question 47

Adverse effect of trastizumab

Answer 47

Cardiotoxicity

Question 48

Drug used in postmenopausal women with ER/PR+ breast cancer

Answer 48

Anastrozole

Question 49

Anastrozole mechanism

Answer 49

Aromatase inhibitor that prevents conversion of androgens to estrogen

Question 50

SERM used in prevention of postmenopausal osteoporosis

Answer 50

Raloxifene