Revision- Lung Cancer Flashcards

1
Q

which transcription factor does lung adenocarcinoma express?

A

TTF 1 (thyroid transcription factor 1)

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2
Q

which nuclear antigen does squamous lung carcinoma express?

A

p63
and high molecular wt. cytokeratins (help cells resist mechanical stress)

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3
Q

what is stridor?

A

wheeze on inspiration

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4
Q

what can cause a hoarse voice in lung cancer?

A

tumour invasion of LEFT recurrent laryngeal nerve at left hilum

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5
Q

which tumour is at lung apex?

A

pancoast tumour

muscles waste away e.g. in hand

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6
Q

local invasion of what can cause distended jugular vein?

A

SVC

puffy eyelids, SVC

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7
Q

what is it called when periosteum becomes inflamed and lift off the bone?

A

Hypertrophic pulmonary osteoarthropathy
associated with squamous

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8
Q

hypercalcemia is typical of which type of lung cancer?

A

squamous

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9
Q

SIADH is typical of what?

A

small cell lung cancer
part cause of hyponatraemia

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10
Q

hyponatremia is typical of what?

A

small cell lung canecer

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11
Q

what is the most common type of lung cancer?

A

adenocarcinoma

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12
Q

which lung cancer type is associate with non smokers?

A

adenocarcinoma

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13
Q

ACTH is associated with which type of lung cancer?

A

small cell

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14
Q

what is it called when periosteum becomes inflamed and lift off the bone?

A

Hypertrophic pulmonary osteoarthropathy
joint stiffness, wrist/ ankle pain

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14
Q

ADH is associated with which type of lung cancer?

A

small cell

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15
Q

cushings is associated with excretion of what/ which type?

A

ACTH
small cell lung cancer

16
Q

what are the peripheral lung cancers?

A

large cell
adenocarcinoma

17
Q

what are the central lung cancers?

A

small cell
squamous

18
Q

what is thrombophlebitis?

A

blood clot formation

19
Q

common sites of primary lung cancer metastases?

A
  • Brain
  • Liver
  • Adrenal
  • Bone
  • Lymph nodes
20
Q

commonest cause of mesothelioma?

A

asbestos
(chrysotile asbestos fibres)

21
Q

how is mesothelioma diagnosed?

A

histology from thoracoscopy

22
Q

mesothelioma management?

A

pleurodesis
drain
long term pleural catheter