Reward System Flashcards
What type of drivers do we have?
Extrinsiv and intrinsic
How d we react to a threat?
Avoidance
What does the reward system do?
Produces spikes in the release of dopamine in brain regions connected with pleasure to enhance motivation
Key Neurotransmitter + facts
Dopamine
–> not about the pleasure itself but the motivation towards it, spikes in anticipation
Effect of too much/little dopamine
To little = Depression or lack of motivation
Too much = addictive behaviours
Where are the dopaminergic pathways mostly located?
Limbic system and PFC
Functions of dopamine (4)
Reward and motivation
Fine tuning motor functions
Compulsion
Perseveration
Too much dopamine leads to …
Too little leads to …
Abnormalities lead to …
Addiction (mesolimbic)
Depression (mesocortical)
Schizophrenia
–> Hyperactive mesolimbic, hypolimbic mesocortical
Dopamine in neurodegenerative conditions
–> Parkinson’s
(dopamine deficiency in the nigostriatal pathway)
Dopamine in neurodevelopmental conditions
–> ADHD
(dopamine dysregulation, deficit in mesolimbic)
Parts of the dopaminergic pathways (9)
- Dopaminergic regions
- Dopaminergic receptive regions
- GABAergic projections
- VTA –> Dopamine production
- Striatum
- Nucleus accumbens
- Hipocampus
- Amygdala
- PFC
What is GABA?
neurotransmitter, inhibits excitatory response
Which is the dopamine-richest part of the brain?
Striatum
3 pathways for dopamine
- Nigrostriatal
- Mesolimbic
- Mesocortical
Nigostriatal Pathways
From substantia nigra to striatum.
Fine-tuning of motor functions
Mesolimbic
From ventral tegmental area to striatum. Reward and motivation
Mesorcortical
VTA to PFC.
Executive and cognitive functioning (planning and goal-directed motivation)
“wanting”
desire or motivation to obtain rewards.
–> dopaminergic pathways
“liking”
pleasure of hedonic aspect of rewards
–> mediated by opioidergic and endocannabinoids systems in areas like the nucleus accumbens
Are wanting and liking different?
Yes, very much so, but they’re related
–> dopamine plays a supporting role in controlling and enhancing hedonic pleasure
–> but there must be a balance between these
What is addiction?
A persistent release of dopamine produces an intense experience of wanting but not liking
–> this means that one gets desensitized as the pleasure derived gets lowers creating a self-destructive cycle
What happens when addiction progresses?
- Affects the PFC and limbic system
- Drug related cues get stored in amygdala and hippocampus turning everyday shit into triggers for wanting a drug
Dopamine and Addiction
- higher dopamine levels in the mesolimbic pathway is liked to addiction
When addicted one’s —- undergoes sensitization to wanting and one’s —- becomes desensitized
wanting // liking