Rheum Flashcards

1
Q

Who does SLE affect most?

A

Afro Caribbean women 20-40 years old

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2
Q

List Sx of SLE

A

Polyarthritis, malar rash, mouth ulcers, serositis, nephrotic syndrome

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3
Q

Pain and weakness in proximal muscles. Raised ESR and CRP. Dx?

A

Polymyalgia rheumatica

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4
Q

What is polymyositis?

A

Inflammation of striated muscles leading to proximal muscle weakness

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5
Q

What condition is temporal arteritis associated with?

A

Polymyalgia rheumatica

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6
Q

What is Tx of temporal arteritis?

A

60mg prednisolone Temporal artery biopsy after 3 days

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7
Q

Eye pain, blurred vision, slight photophobia. Dx?

A

Anterior uveitis

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8
Q

What condition are anterior uveitis and conjunctivitis associated with?

A

Ankylosing spondylitis

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9
Q

Red itchy eye. No blurring/photophobia. PMH: ank spon. Dx?

A

Conjunctivitis

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10
Q

Eye pain, redness, reduced visual acuity. Nausea and vomitting. Dx?

A

Acute glaucoma

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11
Q

Sudden onset back pain. Shooting pain down leg. Urinary retention. Absent ankle jerk reflex. Dx?

A

Cauda equina

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12
Q

Ix of cauda equina?

A

URGENT MRI spine

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13
Q

Young man w hip and back pain everyday. Worse in mornings. Has some tendititis. Dx?

A

Ank Spon

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14
Q

Are ESR and CRP raised, normal or low in ank spon?

A

Raised

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15
Q

What does XR spine show in ank spon?

A

Bamboo spine

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16
Q

What is Tx for ank spon/

A

NSAIDs and exercises

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17
Q

What do crystals look like in gout?

A

Negatively birefringant needles

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18
Q

What do crystals look like in pseudogout?

A

Positively birefringant rhomboids

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19
Q

Atypical mononuclear cells on aspiration. Dx?

A

EBV

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20
Q

Reed Steenberg cells on aspiration. Dx?

A

Hodgkins lymphoma

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21
Q

Tx for pseudogout?

A

NSAIDs and aspiration

22
Q

`List causes of pseudogout

A

Hypothyroidism, acormegaly, hyperPTH, Wilsons, haemochromatosis

23
Q

What is the most specific AB for SLE?

A

Anti double stranded DNA

24
Q

What AB is raised in limited systemic sclerosis?

A
25
Q

What condition has raised anti-mitochondrial ABs?

A

PBC

26
Q

SoB, dry cough, crackles on inspiration. Dx?

A

Pulmonary fibrosis

27
Q

List 2 causes of pulmonary fibrosis

A
28
Q

Sudden onset SoB, pleuritic chest pain, tachycardia, tachypnoea. Dx?

A
29
Q

What is the diagnostic Ix of PE?

A
30
Q

Multiple prev DVT and miscarriages. Dx?

A

Anti phospholipid

31
Q

What rheumatalogical condition is anti phosphilipid syndrome associated with?

A
32
Q

Which auto AB is raised in anti phospholipid syndrome?

A

Anti cardiolipin

33
Q

Decreased tear and saliva production. Parotid gland swelling. Dx?

A
34
Q

What is the pathophysiology of primary Sjorgens?

A
35
Q

What is the test for Primary Sjogren’s?

A
36
Q

What is the difference between primary and secondary Sjorgens?

A

Secondary = primary on a background of other tissue disorders eg SLE

37
Q

Cold hands and feet for past 3 months. Worse in mornings and outside. Dx?

A

Raynaud’s

38
Q

What is Tx of Raynaud’s?

A
39
Q

What is microstomia?

A

Beak like nose and small mouth

40
Q

In what condition is microstomia seen?

A
41
Q

What areas of skin are affected in limited systemic sclerosis?

A
42
Q

Splenomegaly and neutropenia. PMH = RA. Dx?

A
43
Q

WHat is Mx of acute gout?

A

NSAIDs eg indomethacin

44
Q

What is discharge medication of gout?

A

Allopurinol and conservative Mx

45
Q

WHat is Behcet’s?

A

Systemic vasculitis of unknown cause

46
Q

Oral ulcers, genital ulcers, occular problems, erythema nodosum. Dx?

A

Behcets

47
Q

What test is specific to Behcets?

A

Skin pathergy test - needle prick lead sto papule formation <48hrs

48
Q

Head getting bigger with bowing of tibia. Sensorineural hearing loss. Dx?

A

Paget’s disease

49
Q

What is Paget’s disease of the bone?

A

Disorder of bone remodelling - constant resorption and formation of bone leading to deformity

50
Q

Serum Ca, serum PO43 and ALP of Pagets?

A

Normal Ca and PO43

Raised ALP