Rheum/musculoskeletal Flashcards
(305 cards)
Deposition of Monosodium urate crystals in joints
gout
Hyperuricemia
uric acid greater than 6.8. Treatment only indicated in those undergoing cytotoxic treatment.
Primary Overproducers
idiopathic, genetic
Secondary Over producers
increased purine consumption, malignancy, psoriasis, enzyme defects.
Primary underexcreters
idiopathic
secondary underexcreters
Most common. decreased renal function, metabolic acidosis, dehydration, meds, lead nephropathy.
Stage 1 gout
elevated uric acid levels with no symptoms.
Stage 2 gout
acute attack of arthritis
stage 3 gout
10 or more acute attacks. chronic swelling and tophi
Podagra
gout affecting the first MTP
Tophi
large aggregated crystals in the joint
Gout presentation
rapid onset, severe pain, redness, warmth and swelling. Usually monoarticular (big toe).
Gout triggers
ETOH, trauma, any medications that change uric acid levels, high purine consumption.
Xray of gout
Joint erosion. “rat bite”
Arthrocentesis of gout
gold standard. needle shaped and NEGATIVE birefringent crystals
24 urine uric acid
overproducers with have more than 800mg on a normal diet.
Acute Gout Attack Treatment
1st line: NSAIDS, indomethacin 50mg TID or naproxen 500mg BID
2nd line: colchicine 1.2mg followed by 0.6mg an hour later then 0.6mg BID.
3rd line: Glucocorticoids
Gout prevention
avoid high purine foods, prophylactic treatment and urate lowering therapy.
Chronic gout treatment indications
frequent attacks, polyarticular, tophi, renal stones.
Gout treatment goals
SUA of 6.0mg or less.
Probenecid
Gout. For underexcreters. Enhances renal excretion. 250mg BID. Avoid with nephrolithiasis and aspirin.
Allopurinol (Xanthine oxidase inhibitor)
Agent of choice for gout. Decreases uric acid synthesis. 300mg a day. renal dosing.
Febuxostat (xanthine oxidase inhibitor)
similar to allopurinol. safe with mild-moderate renal insufficiency.
Chronic gout treatment
urate lowering therapy should be started 2 weeks after an acute attack. need to have prohpylaxis of NSAIDS/colchicine before starting.