Rheumatoid Arthritis Flashcards Preview

PHARM 2 > Rheumatoid Arthritis > Flashcards

Flashcards in Rheumatoid Arthritis Deck (30):
1

3 classes of tx for RA

1) NSAIDs
2) glucocorticoids
3) DMARDs

2

1st DOC for RA

DMARD

3

leflunomaide liver function concern

leflunomide + MTX = inc risk of hepatotoxicity
must monitor

4

which drugs do not prevent disease progression or joint destruction in RA

NSAIDs and corticosteroids

5

which drug reduces/prevents joint damage and can delay progression

DMARDs

6

Biological vs nonbiological: MTX

non biological

7

Biological vs nonbiological: leflunomide

non biological

8

Biological vs nonbiological: hydroxychloroquine

non biological

9

Biological vs nonbiological: sulfasalazine

non biological

10

Biological vs nonbiological: cyclosporine

non biological

11

Biological vs nonbiological: azathioprine

non biological

12

Biological vs nonbiological: cyclophosphamide

non biological

13

Biological vs nonbiological: adalimumab

biological - anti TNF

14

Biological vs nonbiological: infliximab

biological - anti TNF

15

Biological vs nonbiological: etanercept

biological - anti TNF

16

Biological vs nonbiological: anakinra

biological

for mod to severe RA

17

Biological vs nonbiological: rituximab

biological - usually given with MTX or another nonbiological DMARD

18

Biological vs nonbiological: abatacept

biological

given to pt who didn't respond to non-biologicals or anti-TNF

19

cyclosporine AE

nephrotoxicity

20

which drug tx refractory RA

azathioprine

21

which drug is reserved for the most severe cases of rheumatoid

cyclophosphamide

22

DOC for RA

MTX - mild, mod, or severe RA

23

when are biological DMARDs appropriate

more moderate to severe RA

24

if pt doesn't respond to MTX, what next

try combo leflunomide + MTX

25

least toxic of all DMARDs

hydroxychloroquine

26

cyclophosphamide AE

long term use - inc risk of infection and malignancy

27

anti-TNFalpha's (3)

adalimumab
infliximab
etanercept

28

initial tx for RA

non-biological DMARD (MTX) + NSAID or corticoid

if moderate: first line = TNF-inhibitors - biological DMARD + non-biological DMARD

29

mildest RA cases tx

hydroxychloroquine
sulfasalazine

30

first line DOC for RA in moderate to severe

TNF-inhibitors