Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharmacology > Rheumatoid Arthritis & Gout > Flashcards

Rheumatoid Arthritis & Gout Flashcards

(84 cards)

Start Studying
1
Q

Indomethacin class?

A

Non-selective NSAID (eliminate pain, reduce inflammation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Indomethacin for?

A

RA, gout

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Indomethacin side effetcs?

A

Gastric and duodenal ulcers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Naproxen class?

A

Non-selective NSAID (eliminate pain, reduce inflammation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Naproxen for?

A

RA, gout

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Naproxen side effects?

A

Gastric and duodenal ulcers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

COX-2 inhibitor class?

A

Selective NSAID (eliminate pain, reduce inflammation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

COX-2 inhibitors are____conventional NSAIDs for RA?

A

Superseding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

COX-2 inhibitor side effects?

A

Gastric and duodenal ulcers, but 50% less than traditional NSAIDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Quinolines class?

A

DMARDs (antimalarials)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Quinoline mxn?

A

Reduce T-cell activation & chemotaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Quinoline for?

A

RA & SLE, for patients who no longer respond to NSAIDs or cannot tolerate other DMARDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Glucocorticoids (Corticosteroids) class & mxn?

A

DMARDs; Inhibit Phospholipase A2 (inhibit release of arachidonic acid and formation of prostaglandins) + Inhibit cytokine production and prevent induction of COX-2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Glucocorticoids for?

A

RA, Acute Gouty Arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Glucocorticoid side effects?

A

Cushingoid symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Glucocorticoid timing?

A

Fast acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Sulfasalazine class and mxn?

A

DMARD; likely inhibition of IL-1 and TNF-a release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Sulfasalazine for?

A

RA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Sulfasalazine side effects?

A

N/V, HAs, Skin rashes, neutropenia, 30% discontinue drug

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Sulfasalazine timing?

A

Fast acting

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Methotrexate class and mxn?

A

DMARD (immunosuppressive). Inhibits aminoimidazolecarboxamide transformylase (AICAR) and thimidylate sunthase, with secondary effects on PMN chemotaxis; Causes adenosine accumulation which inhibits inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Methotrexate for?

A

RA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Methotrexate side effects?

A

Nausea, stomatitis, hepatotoxicity (rare)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Methotrexate timing?

A

Takes several to start working

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Leflunomide class and mxn?
DMARD (immunosuppressive). Inhibits dihydroorotate dehydrogenase (DHODH) (RLenzyme in de novo pyrimidine synthesis). T-lymphocyte response to stimuli.
26
Leflunomide for?
RA
27
Leflunomide side effects?
Diarrhea, hepatotoxicity (slightly more toxic than MTX)
28
Leflunomide timing?
Takes several weeks to start working
29
Leflunomide a prodrug?
Yes, an oral prodrug
30
Etanercept class and mxn?
BRM, blocks binding of TNF to TNFR (fusion protein of 2 TNF receptors with Fc portion of IgG)
31
Etanercept for?
RA
32
Etanercept dosing?
Twice weekly SubQ inection
33
Infliximab class and mxn?
BRM, blocks binding of TNF to TNFR (chimeric mouse/human IgG)
34
Infliximab for?
RA
35
Infliximab side effect?
Antigenic response to murine monoclonal Abs
36
TNF inhibitors?
Etanercept, Infliximab, Adalimumab, Golimumab, Certolizumab
37
Adalimumab mxn and class?
BRM, blocks binding of TNF to TNFR (fully human IgG)
38
Adalimumab for?
RA
39
Adalimumab dosing?
2 monthly injections
40
Adalimumab side effects?
Fully human so no antigenic response
41
Golimumab mxn and class?
BRM, blocks binding of TNF to TNFR
42
Golimumab for?
RA
43
Golimumab side effects?
Serious infections
44
Certolizumab mxn and class?
BRM, blocks binding of TNF to TNFR
45
Certolizumab for?
RA
46
Certolizumab side effects?
Serious infections
47
Quinolines efficacy and side effects?
Low side effects (except retinal damage with chloroquine), but low efficacy
48
Non-selective NSAIDs?
Indomethacin, Naproxen
49
Immunosuppressive DMARDs?
Methotrexate and Leflunomide
50
DMARD that inhibits IL-1 and TNFa release?
Sulfasalazine
51
IL-1 receptor antagonist?
Anakinra
52
Anakinra for?
RA
53
Anakinra timing?
Short (6 hr) half life, daily tx with high doses
54
Il-6 receptor antagonist?
Tocilizumab
55
Tocilizumab for?
RA
56
Tocilizumab side effects?
Serious infections
57
Rituximab class and mxn?
BRM, Anti-CD20 Ab, reducing circulating B cells
58
Rituximab for?
RA refractory to TNFa inhibitors
59
Rituximab side effects?
Infections, hypersensitivity reactions
60
Abatacept mxn and class?
BRM, inhibits T-cell activation and induces T-cell apoptosis
61
Abatacept for?
RA refractory to MTX or TNFa inhibitors
62
Abatacept side effects?
HAs, infections
63
Uricosuric agent?
Probenecid
64
Probenecid mxn?
Uricosuric agent. Competes with urate at the anionic transport side of the renal tubule and inhibits urate reabsorption.
65
Probenecid for?
Chronic tophaceous gout
66
Probenecid side effects?
GI irritation, urate crystal mobilization and acute gouty arthritis, secretion of weak acids (penicillin) reduced
67
For acute gouty arthritis?
NSAIDs, corticosteroids, colchicine
68
Colchicine for?
Acute gouty arthritis
69
Colchicine mxn?
Prevents tubulin polymerization and leads to inhibition of leukocyte migration, phagocytosis, and cytokine release
70
Colchicine timing?
works in 12-24 hours
71
Colchicine side effects?
N/V/D/Ab pain, Long-term use causes peripheral neuropathy and neutropenia, low therapeutic index
72
Allopurinal mxn?
Reduce uric acid synthesis by inhibiting xanthine oxidase (competitive inhibitor. It is converted to alloxanthine by XO, which is a non-competitive inhibitor of XO.
73
Allopurinol for?
Chronic tophaceous gout
74
Allopurinol side effects?
Acute attacks of gouty arthritis early in tx due to mobilization of urate crystals, hypersensitivity, maculopapular rash in 2%
75
Pegloticase is?
Recombinant stabilized uricase, converts uric acid to allantoin
76
Pegloticase for?
Chronic tophaceous gout
77
Non-purine, non-competitive antagonist of XO?
Febuxostat
78
Useful if allopurinol is not tolerable?
Febuxostat
79
Febuxostat for?
Chronic tophaceous gout
80
Febuxotat side effects?
Nausea, rash, arthralgias
81
Febuxostat is expensive?
Yes
82
TNF inhibitor conjugated to PEG for stabilization?
Certolizumab
83
"Classic" pharmacologic interventions for chronic gout?
Allopurinol, probenecid, febuxostat
84
Concerns for febuxostat remain for?
Cardiovascular safety

Pharmacology (46 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions