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MS and Rheum > Rheumatologic Pleuropulmonary Disease > Flashcards

Rheumatologic Pleuropulmonary Disease Flashcards

(7 cards)

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1
Q

Scleroderma (SS) pathophysiology mediators

A 
IL-8
TNF
MIF1alpha
RANTES
Endothelin-1
TGF-beta
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2
Q

IL-8 in SS

A

early

neutrophil attractant and activator

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3
Q

TNF in SS

A

early

neutrophil attractant and promoter of neutrophil-endothelial binding

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4
Q

MIF1alpha in SS

A

promoter of neutrophil chemotaxis

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5
Q

RANTES in SS

A

acronym for “Regulated on Activation Normal T cell Expressed and Secreted”

T cell recruiter and activator

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6
Q

Endothelin-1 in SS

A

vasoconstriction

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7
Q

TGF-beta

A

late

promoter of fibroplasia

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MS and Rheum (2 decks)

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