Vasculitis Flashcards
(17 cards)
Anti-GBM
capillaries
Henoch-S purpura
venules-->arteriole (TINY) child IgA purpura, arthritis, GN, abdominal pain (skin, joint, kidney, GI)-->PAGAN purpura lower extremities
Cryoglbulinemmic
venules-->arteriole-->bigger Immune complex Hep C IgG and IgM RF positivity (type II and III) purpura w/ ulcers peripheral neuropathy and Raynaud's Secondary sjogren's
Leukocytoclastic
AKA Hypersensitivity angiitis…see other NC
Venule–>capillary–>arterioles
spares internal organs
Meds or infections
similar to serum sickness
Hypocomplementemic urticarial vasulitis
Connective Tissue Disease Assoc (CTD)
Rheumatoid Vasculitis
Erythema Elevatum Diutinum–>skin, extensor hands and knees
Microscopic polyangiitis
Venule–>small-sized artery–> medium sized
Kidneys (GN), Lung, Neuropathy, Skin
PANCA
Granulomatosis w/ Polyangiitis
Vein-->small-sized artery granulomas White guy Upper and lower respiratory tracts kidneys (ENT, lungs, kidney) saddle nose CANCA (Wegener was a NaCi..Nazi) (PR3)
histo has rheumatoid nodule-like spots
geographic necrosis
Churg-Strauss syndrome
AGPA
Vein-->small-sized artery granulomas PANCA (Churg-Strauss was NOT a Nazi) peripheral neuropathy GU involvement (i.e. prostate)
Wegener’s + eosinophils
Polyarteritis nodosa
medium sized arteries–>aorta
male
Hep B (changes Rx…antivirals & plasma exchange)
neuropathy
Kidney involvement (NOT GN/ RBC casts though)
GI, testicular, cardiac, skin
SPARES lungs
fibrinoid necrosis
cutaneous version (Hep C)
Can confuse w/ RV
Acute: PMNs +/- thrombus, occlusions, rupture
branchpoint of arteries
Chronic: fibroblasts +/- aneurysms
LESIONS AT DIFFERENT PHASES!!
ST
Kawasaki dz
medium sized arteries-->aorta asian child coronary arteries immune activation and cytokines fever, rash, bilateral eyes, LAD, extremeties, mucus membranes (i.e. strawberry tongue!)--> cardiac problems most mortality lymphocytosis Aspirin
endothelial necrosis
aneurisms
Buerger’s dz
thromboangiitis obliterans
arteriole-->medium/muscular artery granuloma young male smokers lower limbs Antibodies against ECM and endothelial cells ANCAs
ACUTE: no Necrosis
Chronic: organization of thrombus
Giant cell arteritis
aorta and primary branches granuloma >50 white female polymyalgia rheumatica assoc/overlap\ empirical prednisone Rx IFN-y headaches+ visual+ jaw
lymphocytes
ST
Takayasu’s
aorta and primary branches
granuloma
thin)
ST
Cogan’s Syndrome
aorta and primary branches granuloma young adults painful eyes/ hearing loss aneurysm
DON’T confuse w/ Susac’s syndrome
Susac’s syndrome
endotheliopathy
sudden onset of hearing loss and eye probblems
Hypersensitivity vasculitis
Small vessels
immune complex
SLE, Sjogren’s, RA assoc
Cutaneous involvement!!–>palpable purpura esp.
Med or infection rxn
Primary Angiitis of CNS
brain, meninges, spinal cord
Rule out mimics (i.e. RCVS)
Granulomatous angiitis of CNS=subset in middle-aged men
Atypical CNS= subset w/ lymphocytic rather than granuloma
Behcet’s dz
complex, multi-system oral and genital ulcers eyes and skin Silk route epidemiology young HLA-B51 neutrophilic vascular rxn
