Vasculitis Flashcards Preview

Question 1

1

Anti-GBM

Answer

capillaries

Question 2

2

Henoch-S purpura

Answer

venules-->arteriole (TINY)
child
IgA
purpura, arthritis, GN, abdominal pain
(skin, joint, kidney, GI)-->PAGAN
purpura lower extremities

Question 3

3

Cryoglbulinemmic

Answer

venules-->arteriole-->bigger
Immune complex
Hep C
IgG and IgM
RF positivity (type II and III)
purpura w/ ulcers
peripheral neuropathy and Raynaud's
Secondary sjogren's

Question 4

4

Leukocytoclastic
(AKA Hypersensitivity angiitis...see other NC)

Answer

Venule-->capillary-->arterioles
spares internal organs
Meds or infections
similar to serum sickness

Hypocomplementemic urticarial vasulitis
Connective Tissue Disease Assoc (CTD)
Rheumatoid Vasculitis
Erythema Elevatum Diutinum-->skin, extensor hands and knees

Question 5

5

Microscopic polyangiitis

Answer

Venule-->small-sized artery--> medium sized
Kidneys (GN), Lung, Neuropathy, Skin
PANCA

Question 6

6

Granulomatosis w/ Polyangiitis

Answer

Vein-->small-sized artery
granulomas
White guy
Upper and lower respiratory tracts
kidneys (ENT, lungs, kidney)
saddle nose
CANCA (Wegener was a NaCi..Nazi) (PR3)

histo has rheumatoid nodule-like spots
geographic necrosis

Question 7

7

Churg-Strauss syndrome
AGPA

Answer

Vein-->small-sized artery
granulomas
PANCA (Churg-Strauss was NOT a Nazi)
peripheral neuropathy
GU involvement (i.e. prostate)

Wegener's + eosinophils

Question 8

8

Polyarteritis nodosa

Answer

medium sized arteries-->aorta
male
Hep B (changes Rx...antivirals & plasma exchange)
neuropathy
Kidney involvement (NOT GN/ RBC casts though)
GI, testicular, cardiac, skin

SPARES lungs

fibrinoid necrosis

cutaneous version (Hep C)

Can confuse w/ RV

Acute: PMNs +/- thrombus, occlusions, rupture
branchpoint of arteries
Chronic: fibroblasts +/- aneurysms

LESIONS AT DIFFERENT PHASES!!
ST

Question 9

9

Kawasaki dz

Answer

medium sized arteries-->aorta
asian child
coronary arteries
immune activation and cytokines
fever, rash, bilateral eyes, LAD, extremeties, mucus membranes (i.e. strawberry tongue!)--> cardiac problems most mortality
lymphocytosis
Aspirin

endothelial necrosis
aneurisms

Question 10

10

Buerger's dz
thromboangiitis obliterans

Answer

arteriole-->medium/muscular artery
granuloma
young male smokers
lower limbs
Antibodies against ECM and endothelial cells
ANCAs

ACUTE: no Necrosis
Chronic: organization of thrombus

Question 11

11

Giant cell arteritis

Answer

aorta and primary branches
granuloma
>50 white female
polymyalgia rheumatica assoc/overlap\
empirical prednisone Rx
IFN-y
headaches+ visual+ jaw

lymphocytes
ST

Question 12

12

Takayasu's

Answer

aorta and primary branches
granuloma
thin)
ST

Question 13

13

Cogan's Syndrome

Answer

aorta and primary branches
granuloma
young adults
painful eyes/ hearing loss
aneurysm

DON'T confuse w/ Susac's syndrome

Question 14

14

Susac's syndrome

Answer

endotheliopathy
sudden onset of hearing loss and eye probblems

Question 15

15

Hypersensitivity vasculitis

Answer

Small vessels
immune complex
SLE, Sjogren's, RA assoc
Cutaneous involvement!!-->palpable purpura esp.

Med or infection rxn

Question 16

16

Primary Angiitis of CNS

Answer

brain, meninges, spinal cord
Rule out mimics (i.e. RCVS)

Granulomatous angiitis of CNS=subset in middle-aged men
Atypical CNS= subset w/ lymphocytic rather than granuloma

Question 17

17

Behcet's dz

Answer

complex, multi-system
oral and genital ulcers
eyes and skin
Silk route epidemiology
young
HLA-B51
neutrophilic vascular rxn

Vasculitis Flashcards Preview

MS and Rheum > Vasculitis > Flashcards

Anti-GBM

capillaries

Henoch-S purpura

venules-->arteriole (TINY)
child
IgA
purpura, arthritis, GN, abdominal pain
(skin, joint, kidney, GI)-->PAGAN
purpura lower extremities

Cryoglbulinemmic

venules-->arteriole-->bigger
Immune complex
Hep C
IgG and IgM
RF positivity (type II and III)
purpura w/ ulcers
peripheral neuropathy and Raynaud's
Secondary sjogren's

Leukocytoclastic
(AKA Hypersensitivity angiitis...see other NC)

Venule-->capillary-->arterioles
spares internal organs
Meds or infections
similar to serum sickness

Hypocomplementemic urticarial vasulitis
Connective Tissue Disease Assoc (CTD)
Rheumatoid Vasculitis
Erythema Elevatum Diutinum-->skin, extensor hands and knees

Microscopic polyangiitis

Venule-->small-sized artery--> medium sized
Kidneys (GN), Lung, Neuropathy, Skin
PANCA

Granulomatosis w/ Polyangiitis

Vein-->small-sized artery
granulomas
White guy
Upper and lower respiratory tracts
kidneys (ENT, lungs, kidney)
saddle nose
CANCA (Wegener was a NaCi..Nazi) (PR3)

histo has rheumatoid nodule-like spots
geographic necrosis

Churg-Strauss syndrome
AGPA

Vein-->small-sized artery
granulomas
PANCA (Churg-Strauss was NOT a Nazi)
peripheral neuropathy
GU involvement (i.e. prostate)

Wegener's + eosinophils

Polyarteritis nodosa

Kawasaki dz

medium sized arteries-->aorta
asian child
coronary arteries
immune activation and cytokines
fever, rash, bilateral eyes, LAD, extremeties, mucus membranes (i.e. strawberry tongue!)--> cardiac problems most mortality
lymphocytosis
Aspirin

endothelial necrosis
aneurisms

Buerger's dz
thromboangiitis obliterans

arteriole-->medium/muscular artery
granuloma
young male smokers
lower limbs
Antibodies against ECM and endothelial cells
ANCAs

ACUTE: no Necrosis
Chronic: organization of thrombus

Giant cell arteritis

aorta and primary branches
granuloma
>50 white female
polymyalgia rheumatica assoc/overlap\
empirical prednisone Rx
IFN-y
headaches+ visual+ jaw

lymphocytes
ST

Takayasu's

aorta and primary branches
granuloma
thin)
ST

Cogan's Syndrome

aorta and primary branches
granuloma
young adults
painful eyes/ hearing loss
aneurysm

DON'T confuse w/ Susac's syndrome

Susac's syndrome

endotheliopathy
sudden onset of hearing loss and eye probblems

Hypersensitivity vasculitis

Small vessels
immune complex
SLE, Sjogren's, RA assoc
Cutaneous involvement!!-->palpable purpura esp.

Med or infection rxn

Primary Angiitis of CNS

brain, meninges, spinal cord
Rule out mimics (i.e. RCVS)

Granulomatous angiitis of CNS=subset in middle-aged men
Atypical CNS= subset w/ lymphocytic rather than granuloma

Behcet's dz

complex, multi-system
oral and genital ulcers
eyes and skin
Silk route epidemiology
young
HLA-B51
neutrophilic vascular rxn

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Vasculitis Flashcards Preview

MS and Rheum > Vasculitis > Flashcards

Anti-GBM

capillaries

Henoch-S purpura

venules-->arteriole (TINY)childIgApurpura, arthritis, GN, abdominal pain(skin, joint, kidney, GI)-->PAGANpurpura lower extremities

Cryoglbulinemmic

venules-->arteriole-->biggerImmune complexHep CIgG and IgMRF positivity (type II and III)purpura w/ ulcersperipheral neuropathy and Raynaud'sSecondary sjogren's

Leukocytoclastic(AKA Hypersensitivity angiitis...see other NC)

Venule-->capillary-->arteriolesspares internal organsMeds or infectionssimilar to serum sicknessHypocomplementemic urticarial vasulitisConnective Tissue Disease Assoc (CTD)Rheumatoid VasculitisErythema Elevatum Diutinum-->skin, extensor hands and knees

Microscopic polyangiitis

Venule-->small-sized artery--> medium sizedKidneys (GN), Lung, Neuropathy, SkinPANCA

Granulomatosis w/ Polyangiitis

Vein-->small-sized arterygranulomasWhite guyUpper and lower respiratory tractskidneys (ENT, lungs, kidney)saddle noseCANCA (Wegener was a NaCi..Nazi) (PR3)histo has rheumatoid nodule-like spotsgeographic necrosis

Churg-Strauss syndromeAGPA

Vein-->small-sized arterygranulomasPANCA (Churg-Strauss was NOT a Nazi)peripheral neuropathyGU involvement (i.e. prostate)Wegener's + eosinophils

Polyarteritis nodosa

Kawasaki dz

medium sized arteries-->aortaasian childcoronary arteriesimmune activation and cytokinesfever, rash, bilateral eyes, LAD, extremeties, mucus membranes (i.e. strawberry tongue!)--> cardiac problems most mortalitylymphocytosisAspirinendothelial necrosisaneurisms

Buerger's dzthromboangiitis obliterans

arteriole-->medium/muscular arterygranulomayoung male smokerslower limbsAntibodies against ECM and endothelial cellsANCAsACUTE: no NecrosisChronic: organization of thrombus

Giant cell arteritis

aorta and primary branchesgranuloma>50 white femalepolymyalgia rheumatica assoc/overlap\empirical prednisone RxIFN-yheadaches+ visual+ jawlymphocytesST

Takayasu's

aorta and primary branchesgranulomathin)ST

Cogan's Syndrome

aorta and primary branchesgranulomayoung adultspainful eyes/ hearing lossaneurysmDON'T confuse w/ Susac's syndrome

Susac's syndrome

endotheliopathysudden onset of hearing loss and eye probblems

Hypersensitivity vasculitis

Small vesselsimmune complexSLE, Sjogren's, RA assocCutaneous involvement!!-->palpable purpura esp.Med or infection rxn

Primary Angiitis of CNS

brain, meninges, spinal cordRule out mimics (i.e. RCVS)Granulomatous angiitis of CNS=subset in middle-aged menAtypical CNS= subset w/ lymphocytic rather than granuloma

Behcet's dz

complex, multi-systemoral and genital ulcerseyes and skinSilk route epidemiologyyoungHLA-B51neutrophilic vascular rxn

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venules-->arteriole (TINY)
child
IgA
purpura, arthritis, GN, abdominal pain
(skin, joint, kidney, GI)-->PAGAN
purpura lower extremities

venules-->arteriole-->bigger
Immune complex
Hep C
IgG and IgM
RF positivity (type II and III)
purpura w/ ulcers
peripheral neuropathy and Raynaud's
Secondary sjogren's

Leukocytoclastic
(AKA Hypersensitivity angiitis...see other NC)

Venule-->capillary-->arterioles
spares internal organs
Meds or infections
similar to serum sickness

Hypocomplementemic urticarial vasulitis
Connective Tissue Disease Assoc (CTD)
Rheumatoid Vasculitis
Erythema Elevatum Diutinum-->skin, extensor hands and knees

Venule-->small-sized artery--> medium sized
Kidneys (GN), Lung, Neuropathy, Skin
PANCA

Vein-->small-sized artery
granulomas
White guy
Upper and lower respiratory tracts
kidneys (ENT, lungs, kidney)
saddle nose
CANCA (Wegener was a NaCi..Nazi) (PR3)

histo has rheumatoid nodule-like spots
geographic necrosis

Churg-Strauss syndrome
AGPA

Vein-->small-sized artery
granulomas
PANCA (Churg-Strauss was NOT a Nazi)
peripheral neuropathy
GU involvement (i.e. prostate)

Wegener's + eosinophils

medium sized arteries-->aorta
asian child
coronary arteries
immune activation and cytokines
fever, rash, bilateral eyes, LAD, extremeties, mucus membranes (i.e. strawberry tongue!)--> cardiac problems most mortality
lymphocytosis
Aspirin

endothelial necrosis
aneurisms

Buerger's dz
thromboangiitis obliterans

arteriole-->medium/muscular artery
granuloma
young male smokers
lower limbs
Antibodies against ECM and endothelial cells
ANCAs

ACUTE: no Necrosis
Chronic: organization of thrombus

aorta and primary branches
granuloma
>50 white female
polymyalgia rheumatica assoc/overlap\
empirical prednisone Rx
IFN-y
headaches+ visual+ jaw

lymphocytes
ST

aorta and primary branches
granuloma
thin)
ST

aorta and primary branches
granuloma
young adults
painful eyes/ hearing loss
aneurysm

DON'T confuse w/ Susac's syndrome

endotheliopathy
sudden onset of hearing loss and eye probblems

Small vessels
immune complex
SLE, Sjogren's, RA assoc
Cutaneous involvement!!-->palpable purpura esp.

Med or infection rxn

brain, meninges, spinal cord
Rule out mimics (i.e. RCVS)

Granulomatous angiitis of CNS=subset in middle-aged men
Atypical CNS= subset w/ lymphocytic rather than granuloma

complex, multi-system
oral and genital ulcers
eyes and skin
Silk route epidemiology
young
HLA-B51
neutrophilic vascular rxn