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BPT Written > Rheumatology > Flashcards

Rheumatology Flashcards

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1
Q

what is the most suggestive XR change of RA?

A

periarticular osteopaenia

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2
Q

which rheum condition has the lowest rates of infections related to TNF-i?

A

Ank spond

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3
Q

what medication should be avoided in an acute exacerbation of PsA?

A

Prednisolone

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4
Q

Radiology of RA

A

corner erosions, peri-articular osteoporosis, loss of joint space, DIPs spared

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5
Q

Radiology of OA

A

Joint space loss, sclerosis, osteophytes, subchondral cysts, ‘seagull’ in DIP

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6
Q

Radiology of haemachromatosis

A

OA changes of MCPs, esp 2nd/3rd

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7
Q

CPPD distribution

A

radiocarpal, patellofemoral

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8
Q

Radiology gout

A

punched out holes w. preserved cortex (intraosseous); inside capsule (destructive to joint), tophi

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9
Q

Psoriatic arthritis radiology

A

DIPs- pencil in cup. Mouse ear erosions, fusion of DIPs

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10
Q

Ank Spond radiology

A

romanus lesion, shiny corner sign, syndesmophytes, SIJ-ilitis

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11
Q

Felty’s syndrome

A

RA, splenomegaly, neutropaenia, leg ulcers

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12
Q

2 main MSK sites to get inflamed in RA other than joints (synovitis)

A

tenosynovitis, osteitis

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13
Q

Drug that accelerates RA nodules

A

methotrexate

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14
Q

HLA group for RA

A

DRB10404

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15
Q

Why is smoking a trigger for RA?

A

results in citrullinated peptides via PAD

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16
Q

Why is periodontitis a trigger for RA?

A

P. gingivalis has PAD

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17
Q

RA vasculitis typically found where?

A

Nailfolds

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18
Q

Main spinal issue in RA

A

atlantoaxial subluxation

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19
Q

RA poor prognostic features

A

extra-articular features, female, high titre RF/anti-CCP, later age of onset, more joints, imaging changes

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20
Q

Main SE of Leflunomide

A

Diarrhoea

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21
Q

Leflunomide MOA

A

Inhibits DHODH, purine synthesis

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22
Q

Above which dose of glucocorticoid does mortality increase?

A

8mg/day

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23
Q

Best TNFi for pregnancy

A

Certolizumab

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24
Q

Main viral infection that mimics RA

A

Parvovirus

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25
What is Anti-centromere Ab protective for?
ILD
26
What 2 things is anti-RNA Pol III assoc. w. ?
Renal crisis, malignancy
27
2 drugs assoc. w. SScl renal crisis
Prednisolone, cyclosporin
28
3x XR features of SSc
Acro-osteolysis, calcinosis, pulp atrophy
29
Primary cause of death in SScl
Lung disease
30
Most common pattern of ILD in SScl
NSIP
31
Two drugs for SScl ILD
MMF or cyclophosphamide
32
G1 pHTN is similar in both, but slightly more common in...
Limited cutaneous Sscl
33
Cardiac MRI findings in SScl
delayed gad enhancement (Gad gets trapped in fibrosis)
34
Which myositis gives perivascular inflammation on biopsy?
DM
35
Which myositis gives degenerating and regenerating fibres, ghost cells and necrosis on biopsy?
IMNM
36
Which myositis gives muscle focused inflammation on biopsy
PM
37
Myositis assoc. w. Anti-SRP and HMGCR
IMNM
38
Myositis assoc. w. Anti-Jo1
Anti-synthetase
39
Myositis assoc. w. TIF1gamma
DM
40
Myositis assoc. w. Anti-NXP2
DM
41
Myositis assoc. w. Anti-cN1a
IBM
42
Anti-MDA5 gives...
Amyopathic DM with a rapidly progressive ILD
43
4 key parts of anti-synthetase syndrome
Myositis, ILD, mechanic's hands, fever
44
Typical ILD pattern of anti-synthetase syndrome
Mostly NSIP or organising pneumonia, but can get UIP
45
Association of ALL forms of spondyloarthropathies
HLA-B27
46
csDMARds used in periphal SpA
MTx, sulfasalazine, leflunomide
47
If uveitis or IBD flavour to SpA use
Direct TNF-alpha inhibitors (No etanercept)
48
Two MAB classes used in SpAs
TNF, IL-17
49
Sacroilitis x3 XR changes
sclerosis, erosions, ankylosis
50
DISH XR changes
chunky osteophytes, no sacroiliitis
51
Most common infectious trigger of reactive arthritis
C. trachomatis
52
Iatrogenic related trigger of reactive arthritis
Intravesical BCG
53
2 key skin manifestations of reactive arthritis
EN and keratoderma blennorhagicum
54
What proportion of PsA partients are HLA B27 +ve?
1/3rd
55
What infection can cause a severe worsening of psoriasis/ can trigger onset in PsA?
HIV
56
Medications that can worsen psoriasis
Steroids, TNF-alpha
57
Best DMARD for peripheral arthritis of PsA
MTx
58
Skin' nail sign most predictive of PsA
pitting
59
Which antibodies are likely to be present in CNS lupus?
ANti-Sm
60
Key difference between Jaccoud's and RA
Non-erosive, correctable
61
Anti-Sm associations
SLE renal and neurological
62
Anti-DFS70 significance
Negative predictor of SLE
63
Biggest predictor of morality in SLE
renal lupus
64
Belimumab MOA
Inhibits BLyS
65
Best DMARD for SLE Renal vs. Joint
MMF vs. MTx
66
3 obstetric criteria APLS
1 fetal death >10 weeks, 3 spont abortions <10 weeks, 1 premature birth <34 weeks
67
Test for lupus anticoagulant
dliute russel viper test
68
Classic Ab at highest risk of thrombosis
lupus anticoagulant
69
New Ab which gives the highest thrombotic risk in APLS
B2 glycoprotein DOMAIN 1 Ab
70
Who should get primary prophylaxis in APLS
Triple +ve; SLE and any Ab
71
Mgmt of arterial embolism in APLS
Aspirin and Warfarin
72
Maintenance rx for AAV
steroids and AZA
73
Is PO or IV cyclophosphamide better in AAV?
PO because less relapse
74
Target for urate in gout
tophi <0.3, non-tophaceous 0.36
75
Avacopan MOA
C5a inhibitor
76
Biopsying which 2 sites is rarely useful in AAV
skin and nasal mucosa
77
Key cell type in GCA
CD4+

BPT Written (21 decks)

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