Richardson - Lymphoid Tissue

Question 1

Function of lymphoid tissues

Answer 1

Protect body from foreign substances and organisms

Distinguish self from non-self

Remove infected, damaged, or cancerous cells

Question 2

Molecules that bind to antibodies or the T cell receptors

(Antibodies bind small regions of large molecules)

(T cell receptors bind small peptides processed from larger proteins)

Answer 2

Antigen

Question 3

The N terminal region of heavy and light chains in antibodies is ____

Answer 3

Highly variable

Question 4

Membrane bound antibodies have a _______ domain at the C terminal

Answer 4

Transmembrane

Question 5

Form: membrane and secreted pentamer

Function: B cell antigen receptor

Answer 5

IgM

Question 6

Form: membrane

Function: B cell antigen receptor:

Answer 6

IgD

Question 7

Form: secreted, major immunoglobulin found in serum

Function: phagocytosis, Neonatal immunity

Answer 7

IgG

Question 8

Form: secreted, binds to receptors on mast cells

Function: allergic reactions, parasites

Answer 8

IgE

Question 9

Form: secreted Dimer

Function: mucosal immunity

Answer 9

IgA

Question 10

Membrane bound antibodies
• Recognize epitopes on a variety of
extracellular macromolecules

Answer 10

B lymphocytes

Question 11

• T cell receptor (TCR)
• Recognizes small peptides on the surface
of antigen presenting cells or infected cells

Answer 11

T Lymphocytes

Question 12

Initial recognition and processing of antigens, done by dendritic cells, macrophages, and neutrophils

Answer 12

Innate immunity

Question 13

Immune response and effector function

Lymphocytes
b cells - humoral
T cells- cell mediated

Plasma cells

Answer 13

Adaptive immunity

Question 14

Part of adaptive immunity

Function to produce large quantities of antibodies

Answer 14

Plasma cells

Question 15

Part of adaptive immunity.

Recoginzes antigens inside cells that are presented to the TCR

Answer 15

T Cells - cell mediated immunity

Question 16

Part of adaptive immunity

Recognizes antigens outside the cell

Answer 16

B cells - humoral immunity

Question 17

Neutrophils, macrophages, and langerhans cells are all part of the -_____- immmune system

Answer 17

Innate

Question 18

Immature T cells migrate to _____ for further maturation

Answer 18

Thymus

Question 19

Where does the negative selection for T cells that recognize self too strongly occur? (This prevents autoimmune disease)

Answer 19

Thymus

Question 20

Filter for the lymph

Answer 20

Lymph nodes

Question 21

Filter for the blood

Removal of aged red blood cells

Answer 21

Spleen

Question 22

• Located throughout the
body along lymph
vessels • Filter for the lymph
• Monitors for foreign
antigens in tissues • Adaptive immune
responses to lymph-
borne antigens initiated

Answer 22

Lymph nodes

Question 23

Lymphocytes enter lymph nodes from blood through

Answer 23

High endothelial venules (HEV)

Question 24

Lymphocytes leave lymph nodes via

Answer 24

Efferent lymphatic vessels

Question 25

Lymphocytes enter blood circulation through

Answer 25

Lymphatic ducts

Question 26

High endothelial venules are found in secondary lymphoid tissues except___

Answer 26

Spleen

Question 27

Where is mucosa -associated Lymphoid tissue (MALT) found?

Answer 27

In lamina propria underlying the mucosal epithelium of tissues w openings to external environment GI tract Respiratory tract Reproductive tract

Question 28

The T cell receptors bind ____

Answer 28

Small peptides processed from larger proteins

Question 29

Immunoglobulin isotypes that are found in membranes

Answer 29

IgM | IgD

Question 30

Pentamer immunoglobulin isotype

Answer 30

IgM

Question 31

Major functions for lymph nodes

Answer 31

Filter lymph Phagocytosis of bacteria / foreign substances from lymph

Question 32

After entering the lymph nodes, B cells congregate on _______ of lymph nodes’ outer cortex

Answer 32

Lymphatic nodules

Question 33

T cells congregate _____ the lymphatic nodules in the deep cortical or paracortical regions

Answer 33

Below

Question 34

Lymph nodes are the location of _____ and _____ of B cells which gives rise to plasma cells and memory B cells

Answer 34

Antigenic recognition and antigenic activation

Question 35

Circulating lymphocytes recognize __________ on high endothelial cells to know to enter lymph nodes from the blood

Answer 35

Lymphocyte homing receptors

Question 36

In spleen; white pulp contains ?

Answer 36

B and T lymphocytes

Question 37

In spleen; red pulp contains __

Answer 37

RBC’s, macrophages, and other blood cells

Question 38

Ciliated pseudostratified columnar epithelium, but can also have stratified squamous epithelium • No crypts

Answer 38

Pharyngeal tonsil

Question 39

Lateral walls of the oral pharynx • Stratified squamous epithelium • Multiple crypts

Answer 39

Palatine tonsil

Question 40

Large amounts of ____ are secreted by plasma cells and subsequently transported across the epithelium into the lumen of the tissue in Mucosa-associated lymphoid tissue (MALT), which is found in lamina propria

Answer 40

IgA

Question 41

Antibodies bind __

Answer 41

Small regions of large molecules

Question 42

Immunoglobulin isotype that binds to mast cells to release histamine

Answer 42

IgE

Question 43

Main function of thymus gland

Answer 43

Produce a diverse group of T cells that can respond to antigens