Risperdal Consta

Question 1

Generic

Answer 1

Risperidone

Question 2

Manufacturer

Answer 2

Janssen

Question 3

Dosage forms

Answer 3

12.5mg
25mg
37.5mg
50mg

Question 4

Steady state

Answer 4

After 4 injections (6 weeks from dose)

Question 5

Indications

Answer 5

Schizophrenia
Monotherapy and adjunct for BP1

Question 6

Clinical trials

Answer 6

12 week 25mg, 50mg, and 75mg every 2 weeks all superior on PANNS Total

Question 7

Oral dose needed prior to injection

Answer 7

Yes, establish tolerability to Risperidal

Question 8

Loading dose

Answer 8

Oral R or another AP given with first injection and continues for three weeks (then discontinued)

Question 9

Maintenance dose

Answer 9

25-50

Question 10

How often

Answer 10

2 weeks

Question 11

Administration site

Answer 11

Deltoid or glute

Question 12

Common s/e

Answer 12

Headache, Parkinson, dizziness, akathisia, fatigue, constipation, dyspepsia, sedation, weight increased, pain in extremity, dry mouth

Question 13

Specific population

Answer 13

Pregnancy, may cause eps/ withdrawal symptoms with neonates in third trimester exposure
Renal, hepatic - dose appropriately, lower may be better
Pediatric, not established in under 18

Question 14

Drug interactions

Answer 14

CNS effects use caution
Hypotensive effects
Levodopa and dopamine may be enhanced
Cimetidine and ranitidine increase bioavailability of risperidone
Fluoxetine and paroxetine increase plasma concentration of risperidone
Carbamazepine and other enzyme inducers decrease risperidone

Question 15

Storage

Answer 15

Refrigerate 36F - 46F
Protect from light
If not then room temperature at less than 77F for no more than 7 days
Do not expose above 77F